Key Features

  • Access reliable, up-to-the-minute guidance that addresses the realities of HIV/AIDS management in your geographical region, thanks to contributions from a global cast of renowned expert clinicians and researchers.
  • Locate the clinically actionable information you need quickly with an organization that mirrors the current state of the AIDS epidemic and the different needs of Western vs. developing-world patients and clinicians.
  • Diagnose AIDS manifestations confidently by comparing them to clinical images.
  • Improve patient outcomes with the latest findings on the management of AIDS as a chronic illness.
  • Efficiently review essential data through numerous at-a-glance tables.

Table of Contents

Contents

Preface vii

Contributors ix

Acknowledgments xv

SECTION 1: Epidemiology and biology of HIV infection

1 The global epidemiology of HIV/AIDS 3

Irum Zaidi, Kevin M De Cock

2 The origins and diversification of HIV 15

Michael Worobey, Guan-Zhu Han

3 Molecular biology of HIV: implications for new therapies 25

Warner C Greene, B Matija Peterlin, Matthew H Stremlau

4 The immune response to HIV 45

Clive M Gray, Pamela Gumbi, Lycias Zembe, Mopo Radebe, Bruce Walker

5 Viral and host determinants of HIV-1 disease progression 59

Danie¨lle van Manen, Ange´lique B van ’t Wout, Hanneke Schuitemaker

6 Acute HIV infection 77

Anthony D Kelleher, David A Cooper

7 Biology of HIV-1 transmission 89

Julie Overbaugh

SECTION 2: Prevention, diagnosis, and treatment of HIV infection

8 The design of a global HIV vaccine 97

Jerome H Kim, Nelson L Michael

9 HIV prevention 113

Salim S Abdool Karim

10 Laboratory testing for HIV infection 123

James C Shepherd, Oliver Laeyendecker, Thomas C Quinn

11 Overview of antiretroviral therapy 133

Susa Coffey, Paul A Volberding

12 Development and transmission of HIV drug resistance 155

Mark A Wainberg, Gerasimos J Zaharatos

13 Pharmacology of antiretroviral drugs 169

Concepta Merry, Charles W Flexner

14 Complications resulting from antiretroviral therapy for HIV infection 177

David Nolan, Simon Mallal, Peter Reiss

SECTION 3: Diseases associated with HIV infection

15 Oral complications of HIV infection 195

John S Greenspan, Deborah Greenspan

16 Ocular manifestations of AIDS 207

James P Dunn

17 Global HIV and dermatology 219

Toby Maurer, Robert Michelleti

18 Gastrointestinal disorders in HIV including diarrhea 237

Marie-L

Details

No. of pages:
596
Language:
English
Copyright:
© 2012
Published:
Imprint:
Saunders
eBook ISBN:
9781455737949
Print ISBN:
9781455706952

About the authors

Paul Volberding

Affiliations and Expertise

Senior Clinical Research Fellow;Marvin Sleisenger Professor and Vice Chair;Department of Medicine University of California San Francisco;San Francisco, CA, USA

Warner Greene

Affiliations and Expertise

Director, Gladstone Institute of Virology and Immunology; Nick and Sue Hellmann Distinguished Professor of Translational Medicine; Professor of Medicine, Microbiology and Immunology; University of California, San Francisco; San Francisco, CA

Joep Lange

Affiliations and Expertise

Professor of Medicine; Global Health; Academic Medical Center, University of Amsterdam; Amsterdam Institute for Global Health and Development; Amsterdam; The Netherlands

Joel Gallant

Affiliations and Expertise

Professor of Medicine and Epidemiology;Associate Director, Johns Hopkins AIDS Service;Division of Infectious Diseases, Department of Medicine;Johns Hopkins University School of Medicine;Baltimore, MD, USA