Sample Preparation in Chromatography, Volume 65

1st Edition

Authors: S.C. Moldoveanu V. David
Hardcover ISBN: 9780444503947
eBook ISBN: 9780080540702
Imprint: Elsevier Science
Published Date: 8th May 2002
Page Count: 942
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Table of Contents

Part 1. Introduction and General Considerations. Preparatory information. Overview of a chemical analysis. Types of operations used in sample preparation. Some theoretical aspects of phase transfers. Introductory approach to theory of distribution equilibrium. Some aspects of mass transfer processes. Characterization of chromatographic separations. General characteristics of separations. Elementary discussion on thermodynamic and kinetic factors in chemical reactions. Brief survey on molecular interactions. Empirical and estimated parameters for sample preparation problems. Introductory discussion on precision, accuracy, sensitivity, and limit of detection in chemical analysis. Validation of an analytical method.

Sampling and Its Connection with Sample Preparation. Relation of sampling to sample preparation. Representative samples. Techniques for sample collection. Handling, preservation, and storage of samples.

Overview on Sample Preparation for Chromatography. The role of sample preparation. The use of preliminary information for the choice of a sample preparation procedure. Sample homogenization and dissolution. Sample cleanup, fractionation, and concentration. Chemical modifications of the sample. Other types of sample modifications. Differences in sample preparation for different chromatographic techniques. Quantitation techniques in chromatography and their relation to sample preparation. Method development in sample preparation.

Chromatography as the Core Step in an Analytical Process.

The choice of the core analytical technique. Gas chromatography as a core step in the analytical process. Conventional high performance liquid chromatography as a core analytical technique.<


Sample preparation is an essential step in many analyses. This book approaches the topic of sample preparation in chromatography in a methodical way, viewing it as a logical connection between sample collection and analytical chromatography. Providing a guide for choosing the appropriate sample preparation for a given analysis, this book describes various ways to process the sample, explaining the principle, discussing the advantages and disadvantages, describing the applicability to different types of samples, and showing the fitness to specific chromatographic determinations.

The first part of the book contains an overview of sample preparation showing its relation to sample collection and to the core chromatographic analysis. The second part covers procedures that do not use chemical modifications of the analyte and includes methods for sample dissolution, concentration and cleanup designed mainly for modifying the initial matrix of the sample. This part starts with conventional separations such as filtration and distillation and finishes with more advanced techniques such as solid phase extraction and electroseparations. The third part gives a description of the chemical modifications that can be performed on a sample either for fractionation purposes or to improve a specific property of the analyte. This part includes derivatizations, polymer chemical degradations, and pyrolysis.


For a wide range of readers, including specialists in analytical chemistry and beginners in this field.


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© Elsevier Science 2002
Elsevier Science
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About the Authors

S.C. Moldoveanu Author

Affiliations and Expertise

Brown & Williamson Tobacco Corporation, 2600 Weaver Rd, Macon, GA 31217, USA

V. David Author

Affiliations and Expertise

Department of Analytical Chemistry, University of Bucharest, Sos. Panduri 90, Sect.5, Bucharest, Romania