Part 1. Introduction and General Considerations.
Preparatory information. Overview of a chemical analysis. Types of operations used in sample preparation. Some theoretical aspects of phase transfers. Introductory approach to theory of distribution equilibrium. Some aspects of mass transfer processes. Characterization of chromatographic separations. General characteristics of separations. Elementary discussion on thermodynamic and kinetic factors in chemical reactions. Brief survey on molecular interactions. Empirical and estimated parameters for sample preparation problems. Introductory discussion on precision, accuracy, sensitivity, and limit of detection in chemical analysis. Validation of an analytical method.
Sampling and Its Connection with Sample Preparation. Relation of sampling to sample preparation. Representative samples. Techniques for sample collection. Handling, preservation, and storage of samples.
Overview on Sample Preparation for Chromatography.
The role of sample preparation.
The use of preliminary information for the choice of a sample preparation procedure.
Sample homogenization and dissolution.
Sample cleanup, fractionation, and concentration.
Chemical modifications of the sample.
Other types of sample modifications.
Differences in sample preparation for different chromatographic techniques.
Quantitation techniques in chromatography and their relation to sample preparation.
Method development in sample preparation.
Chromatography as the Core Step in an Analytical Process.
The choice of the core analytical technique.
Gas chromatography as a core step in the analytical process.
Conventional high performance liquid chromatography as a core analytical technique.<