Ryan's Retina - 6th Edition - ISBN: 9780323401975, 9780323401982

Ryan's Retina

6th Edition

3 Volume Set

Authors: Charles Wilkinson David Hinton SriniVas Sadda Peter Wiedemann
Editor in Chief: Andrew Schachat
eBook ISBN: 9780323401982
Hardcover ISBN: 9780323401975
Imprint: Elsevier
Published Date: 17th April 2017
Page Count: 2976

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The undisputed gold standard text in the field, Ryan's Retina is your award-winning choice for the most current, authoritative information on new technologies, surgical approaches, scientific advances and diagnostic and therapeutic options for retinal diseases and disorders. Packed with timely updates throughout, new illustrations, and a dedicated team of editors who extend Dr. Ryan’s legacy in retina, this outstanding 6th Edition is a must-have reference for retinal specialists, ophthalmologists, and fellows in training.

Key Features

  • Offers the most comprehensive content available on retina, balancing the latest scientific research and clinical correlations, covering everything you need to know on retinal diagnosis, treatment, development, structure, function, and pathophysiology.
  • Provides a truly global perspective from five highly esteemed section editors and more than 350 other world authorities from across Europe, Asia, Australasia, and the Americas.

Table of Contents

Part I: Retinal Imaging and Diagnostics

1. Fluorescein Angiography: Basic Principles and Interpretation

2. Clinical Applications of Diagnostic Indocyanine Green Angiography

3. Optical Coherence Tomography

4. Autofluorescence Imaging

5. Widefield Imaging

6. Intraoperative OCT Imaging

7. Advanced Imaging Technologies

8. Advanced Image Analysis

9. Electrogenesis of the Electroretinogram

10. Clinical Electrophysiology

11. Diagnostic Ophthalmic Ultrasound

12. Color Vision and Night Vision

13. Visual Acuity and Contrast Sensitivity

14. Visual Fields in Retinal Disease

Part 2: Basic Science and Translation to Therapy

Section 1: Anatomy and Physiology

15. The Development of the Retina

16. Structure and Function of Rod and Cone Photoreceptors

17. Function and Anatomy of the Mammalian Retina

18. Cell Biology of the Retinal Pigment Epithelium

19. Cell Biology of Retinal Glia

20. Retinal and Choroidal Vasculature: Retinal Oxygenation

21. Mechanisms of Normal Retinal Adhesion

22. Structure, Function, and Pathology of Bruch’s Membrane

23. Vitreous and Vitreoretinal Interface


Section 2: Basic Mechanisms of Injury in the Retina

24. Mechanisms of Oxidative Stress in Retinal Injury

25. Mechanisms of Endoplasmic Reticulum Stress in Retinal Disease

26. Cell Death, Apoptosis, and Autophagy in Retinal Injury

27. Inflammation and Immune Responses In Retinal Health and Disease

28. Basic Mechanisms of Pathological Retinal and Choroidal Angiogenesis

29. Blood-Retinal Barrier, Immune Privilege, and Autoimmunity

30. Mechanisms of Macular Edema and Therapeutic Approaches

31. Cellular Effects of Detachment and Reattachment on the Neural Retina and the Retinal Pigment Epithelium

32. Pathogenesis of Serous Detachment of the Retina and Pigment Epithelium

Section 3: Genetics

33. Genetic Mechanisms of Retinal Disease

34. Mitochondrial Genetics of Retinal Disease

35. Epigenetic Mechanisms of Retinal Disease

Section 4: Translational Basic Science

36. Gene Therapy for Retinal Disease

37. Stem Cells and Cellular Therapy

38. Nanomedicine in Ophthalmology

39. Neuroprotection

40. Drug Delivery

41. Retinal Laser Therapy: Biophysical Basis and Applications

Medical Retina

Section 1: Retinal Degenerations and Dystrophies

42. Retinitis Pigmentosa and Allied Disorders

43. Hereditary Vitreoretinal Degenerations

44. Macular Dystrophies

45. Hereditary Choroidal Diseases

46. Abnormalities of Cone and Rod Function

Section 2: Retinal Vascular Disease

47. The Epidemiology of Diabetic Retinopathy

48. Diabetic Retinopathy: Genetics and Etiologic Mechanisms

49. Medical Management of Diabetes Mellitus

50. Nonproliferative Diabetic Retinopathy and Diabetic Macular Edema

51. Proliferative Diabetic Retinopathy

52. Hypertension

53. Telescreening for Diabetic Retinopathy

54. Retinal Artery Occlusions

55. Acquired Retinal Macroaneurysms

56. Branch Vein Occlusion

57. Central Retinal Vein Occlusion

58. Macular Telangiectasia

59. Coats Disease

60. Hemoglobinopathies

61. Radiation Retinopathy

62. Ocular Ischemic Syndrome 

63. Coagulopathies

64. Pediatric Retinal Vascular Diseases Retinopathy of Prematurity

65. Telescreening for Retinopathy of Prematurity

Section 3: Choroidal Vascular/Bruch's Membrane Disease

66. Epidemiology and Risk Factors for Age-Related Macular Degeneration

67. Pathogenetic Mechanisms in Age-Related Macular Degeneration

68. Age-Related Macular Degeneration: Non-neovascular Early AMD, Intermediate AMD, and Geographic Atrophy

69. Neovascular (Exudative or "Wet") Age-Related Macular Degeneration

70. Pharmacotherapy of Age-Related Macular Degeneration

71. Pathologic Myopia

72. Angioid Streaks

73. Ocular Histoplasmosis

74. Polypoidal Choroidal Vasculopathy

75. Central Serous Chorioretinopathy

76. Uveal Effusion Syndrome and Hypotony Maculopathy

Section 4: Inflammatory Disease/Uveitis

77. Sympathetic Ophthalmia

78. Vogt-Koyanagi-Harada Disease

79. White Spot Syndromes and Related Diseases

80. Autoimmune Retinopathies

81. Sarcoidosis

82. Intermediate Uveitis

83. Rheumatic Diseases

84. HIV-Associated Infections

85. Mycobacterial Infections

86. Eales Disease

87. Spirochetal Infections

88. Ocular Toxoplasmosis

89. Helminthic Disease

90. Endogenous Endophthalmitis: Bacterial and Fungal

91. Acute Retinal Necrosis Syndrome

Section 5: Miscellaneous

92. Drug Toxicity of the Posterior Segment

93. Photic Retinal Injuries: Mechanisms, Hazards, and Prevention

94. Traumatic Chorioretinopathies 

95. Pregnancy-Related Diseases

96. Optic Disc Anomalies, Pits, and Associated Serous Macular Detachment

97. Retina-Related Clinical Trials: A Resource Bibliography

Surgical Retina

Section 1: The Pathophysiology of Retinal Detachment and Associated Problems

98. Pathogenetic Mechanisms of Retinal Detachment

99. Nonrhegmatogenous Retinal Detachment

100. Senile Retinoschisis

101. Pathogenesis of Proliferative Vitreoretinopathy 

102. Pathophysiology of Ocular Trauma

Section 2: Retinal Reattachment: General Surgical Principles and Techniques

103. The Effects and Action of Scleral Buckles in the Treatment of Retinal Detachment

104. Techniques of Scleral Buckling

105. Principles and Techniques of Vitreoretinal Surgery

106. Primary Vitrectomy in Rhegmatogenous Retinal Detachment

107. Pneumatic Retinopexy

108. Special Adjuncts to Treatment

109. Optimal Procedures for Retinal Detachment Repair

110. Prevention of Retinal Detachment

Section 3: Complicated Forms of Retinal Detachment

111. Proliferative Vitreoretinopathy

112. Retinotomies and Retinectomies

113. Giant Retinal Tear 

114. Surgery for Ocular Trauma: Principles and Techniques of Treatment

115. Surgery for Proliferative Diabetic Retinopathy

116. Management of Combined Inflammatory and Rhegmatogenous Retinal Detachment

117. High Myopia and the Vitreoretinal Complications

118. Surgical Management of Retinopathy of Prematurity

119. Surgery for Pediatric Vitreoretinal Disorders


Section 4: Vitreous Surgery for Macular Disorders

120. Epiretinal Membranes, Vitreoretinal Traction and Cystoid Macular Edema

121. Macular Hole

122. Surgical Management of Choroidal Neovascularization and Subretinal Hemorrhage

123. 360 Degree Macular Translocation

124. Retinal Pigment Epithelium and Choroid Translocation in Patients with Age-Related Macular Degeneration

Section 5: Vitreous Surgery: Additional Considerations

125. Infectious Endophthalmitis

126. Diagnostic and Therapeutic Vitrectomy for Uveitis

127 . Vitreous, Retinal, and Choroidal Biopsy

128. Transplantation Frontiers

129 . Artificial Vision

130. Pharmacology During Surgery

131. Complications In Vitreoretinal Surgery

Tumors of the Retina, Choroid, and Vitreous

Section 1: Tumors of the Retina

132. Retinoblastoma

133. Cavernous Hemangioma

134. Capillary Hemangioblastoma of the Retina and von Hippel-Lindau Disease

135. Tuberous Sclerosis and the Eye

136. Phakomatoses

137. Retinal Metastases

138. Remote Effects of Cancer on the Retina

139. Melanocytoma of the Optic Disc

140. Congenital Hypertrophy of the Retinal Pigment Epithelium

141. Combined Hamartoma of the Retinal Pigment Epithelium and Retina

Section 2: Tumors of the Choroid

142. Choroidal Nevi

143. Epidemiology of Posterior Uveal Melanoma

144. Prognosis of Posterior Uveal Melanoma

145. Molecular Genetics of Choroidal Melanoma

146. Pathology of Choroidal Melanoma

147. Overview of Management of Posterior Uveal Melanoma

148. Enucleation for Choroidal Melanomas

149. Brachytherapy for Choroidal Melanoma

150. Charged-Particle Irradiation of Uveal Melanoma

151. Surgical Resection of Choroidal Melanoma

152. Laser Treatment of Choroidal Melanoma

153. Systemic Evaluation and Management of Patients with Metastatic Uveal Melanoma

154. Collaborative Ocular Melanoma Study

155. Choroidal Metastases

156. Choroidal Osteoma

157. Circumscribed Choroidal Hemangioma

Section 3: Hematologic and Miscellaneous Tumors

158. Miscellaneous Uveal Tumors

159. Leukemias and Lymphomas

160. Primary Vitreoretinal Lymphoma


No. of pages:
© Elsevier 2017
17th April 2017
eBook ISBN:
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About the Authors

Charles Wilkinson

Affiliations and Expertise

Chairman, Department of Ophthalmology, Greater Baltimore Medical Center; Professor, Department of Ophthalmology, John Hopkins University, Baltimore, MD, USA

David Hinton

Affiliations and Expertise

Gavin S. Herbert Professor of Retinal Research; Professor of Pathology and Ophthalmology, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

SriniVas Sadda

Affiliations and Expertise

President & Chief Scientific Officer Doheney Eye Institute Los Angeles, CA

Peter Wiedemann

Dr. Peter Wiedemann is Professor of Ophthalmology at Leipzig University. He is a vitreoretinal specialist whose expertise includes complex vitreoretinal surgery and macular disorders. Dr. Wiedemann earned his medical degree at Erlangen University, Germany. He started ophthalmic research at the Doheny Eye Institute, Los Angeles, with Dr. Stephen Ryan and completed residency and fellowship in ophthalmology at Cologne University with Prof. Klaus Heimann. In his research Dr. Wiedemann studies retinal and macular disorders and Müller cells pathophysiology. He has authored over 500 peer reviewed publications in ophthalmology and is co-editor of the textbook Ryan´s Retina. He is a member of the German National Academy of Sciences Leopoldina, the German Ophthalmological Society, the American Academy of Ophthalmology and the Club Jules Gonin. He is also a Fellow of the Academia Ophthalmologica Internationalis (AOI), the European Academy of Ophthalmology, and a Board Member of the International Council of Ophthalmology (ICO).

Affiliations and Expertise

Head of the Department of Ophthalmology and Eye Hospital, Medical Faculty, University of Leipzig, Leipzig, Germany

About the Editor in Chief

Andrew Schachat

Affiliations and Expertise

Vice Chairman, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH, USA