Ryan's Retina

Ryan's Retina

3 Volume Set

6th Edition - April 17, 2017

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  • Editor-in-Chief: Andrew Schachat
  • eBook ISBN: 9780323401982

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The undisputed gold standard text in the field, Ryan's Retina is your award-winning choice for the most current, authoritative information on new technologies, surgical approaches, scientific advances and diagnostic and therapeutic options for retinal diseases and disorders. Packed with timely updates throughout, new illustrations, and a dedicated team of editors who extend Dr. Ryan’s legacy in retina, this outstanding 6th Edition is a must-have reference for retinal specialists, ophthalmologists, and fellows in training.

Key Features

  • Offers the most comprehensive content available on retina, balancing the latest scientific research and clinical correlations, covering everything you need to know on retinal diagnosis, treatment, development, structure, function, and pathophysiology.
  • Provides a truly global perspective from five highly esteemed section editors and more than 350 other world authorities from across Europe, Asia, Australasia, and the Americas.

Table of Contents

  • Part I: Retinal Imaging and Diagnostics

    1. Fluorescein Angiography: Basic Principles and Interpretation

    2. Clinical Applications of Diagnostic Indocyanine Green Angiography

    3. Optical Coherence Tomography

    4. Autofluorescence Imaging

    5. Widefield Imaging

    6. Intraoperative OCT Imaging

    7. Advanced Imaging Technologies

    8. Advanced Image Analysis

    9. Electrogenesis of the Electroretinogram

    10. Clinical Electrophysiology

    11. Diagnostic Ophthalmic Ultrasound

    12. Color Vision and Night Vision

    13. Visual Acuity and Contrast Sensitivity

    14. Visual Fields in Retinal Disease


    Part 2: Basic Science and Translation to Therapy

    Section 1: Anatomy and Physiology

    15. The Development of the Retina

    16. Structure and Function of Rod and Cone Photoreceptors

    17. Function and Anatomy of the Mammalian Retina

    18. Cell Biology of the Retinal Pigment Epithelium

    19. Cell Biology of Retinal Glia

    20. Retinal and Choroidal Vasculature: Retinal Oxygenation

    21. Mechanisms of Normal Retinal Adhesion

    22. Structure, Function, and Pathology of Bruch’s Membrane

    23. Vitreous and Vitreoretinal Interface


    Section 2: Basic Mechanisms of Injury in the Retina

    24. Mechanisms of Oxidative Stress in Retinal Injury

    25. Mechanisms of Endoplasmic Reticulum Stress in Retinal Disease

    26. Cell Death, Apoptosis, and Autophagy in Retinal Injury

    27. Inflammation and Immune Responses In Retinal Health and Disease

    28. Basic Mechanisms of Pathological Retinal and Choroidal Angiogenesis

    29. Blood-Retinal Barrier, Immune Privilege, and Autoimmunity

    30. Mechanisms of Macular Edema and Therapeutic Approaches

    31. Cellular Effects of Detachment and Reattachment on the Neural Retina and the Retinal Pigment Epithelium

    32. Pathogenesis of Serous Detachment of the Retina and Pigment Epithelium


    Section 3: Genetics

    33. Genetic Mechanisms of Retinal Disease

    34. Mitochondrial Genetics of Retinal Disease

    35. Epigenetic Mechanisms of Retinal Disease


    Section 4: Translational Basic Science

    36. Gene Therapy for Retinal Disease

    37. Stem Cells and Cellular Therapy

    38. Nanomedicine in Ophthalmology

    39. Neuroprotection

    40. Drug Delivery

    41. Retinal Laser Therapy: Biophysical Basis and Applications


    Medical Retina

    Section 1: Retinal Degenerations and Dystrophies

    42. Retinitis Pigmentosa and Allied Disorders

    43. Hereditary Vitreoretinal Degenerations

    44. Macular Dystrophies

    45. Hereditary Choroidal Diseases

    46. Abnormalities of Cone and Rod Function


    Section 2: Retinal Vascular Disease

    47. The Epidemiology of Diabetic Retinopathy

    48. Diabetic Retinopathy: Genetics and Etiologic Mechanisms

    49. Medical Management of Diabetes Mellitus

    50. Nonproliferative Diabetic Retinopathy and Diabetic Macular Edema

    51. Proliferative Diabetic Retinopathy

    52. Hypertension

    53. Telescreening for Diabetic Retinopathy

    54. Retinal Artery Occlusions

    55. Acquired Retinal Macroaneurysms

    56. Branch Vein Occlusion

    57. Central Retinal Vein Occlusion

    58. Macular Telangiectasia

    59. Coats Disease

    60. Hemoglobinopathies

    61. Radiation Retinopathy

    62. Ocular Ischemic Syndrome 

    63. Coagulopathies

    64. Pediatric Retinal Vascular Diseases Retinopathy of Prematurity

    65. Telescreening for Retinopathy of Prematurity


    Section 3: Choroidal Vascular/Bruch's Membrane Disease

    66. Epidemiology and Risk Factors for Age-Related Macular Degeneration

    67. Pathogenetic Mechanisms in Age-Related Macular Degeneration

    68. Age-Related Macular Degeneration: Non-neovascular Early AMD, Intermediate AMD, and Geographic Atrophy

    69. Neovascular (Exudative or "Wet") Age-Related Macular Degeneration

    70. Pharmacotherapy of Age-Related Macular Degeneration

    71. Pathologic Myopia

    72. Angioid Streaks

    73. Ocular Histoplasmosis

    74. Polypoidal Choroidal Vasculopathy

    75. Central Serous Chorioretinopathy

    76. Uveal Effusion Syndrome and Hypotony Maculopathy


    Section 4: Inflammatory Disease/Uveitis

    77. Sympathetic Ophthalmia

    78. Vogt-Koyanagi-Harada Disease

    79. White Spot Syndromes and Related Diseases

    80. Autoimmune Retinopathies

    81. Sarcoidosis

    82. Intermediate Uveitis

    83. Rheumatic Diseases

    84. HIV-Associated Infections

    85. Mycobacterial Infections

    86. Eales Disease

    87. Spirochetal Infections

    88. Ocular Toxoplasmosis

    89. Helminthic Disease

    90. Endogenous Endophthalmitis: Bacterial and Fungal

    91. Acute Retinal Necrosis Syndrome


    Section 5: Miscellaneous

    92. Drug Toxicity of the Posterior Segment

    93. Photic Retinal Injuries: Mechanisms, Hazards, and Prevention

    94. Traumatic Chorioretinopathies 

    95. Pregnancy-Related Diseases

    96. Optic Disc Anomalies, Pits, and Associated Serous Macular Detachment

    97. Retina-Related Clinical Trials: A Resource Bibliography


    Surgical Retina

    Section 1: The Pathophysiology of Retinal Detachment and Associated Problems

    98. Pathogenetic Mechanisms of Retinal Detachment

    99. Nonrhegmatogenous Retinal Detachment

    100. Senile Retinoschisis

    101. Pathogenesis of Proliferative Vitreoretinopathy 

    102. Pathophysiology of Ocular Trauma


    Section 2: Retinal Reattachment: General Surgical Principles and Techniques

    103. The Effects and Action of Scleral Buckles in the Treatment of Retinal Detachment

    104. Techniques of Scleral Buckling

    105. Principles and Techniques of Vitreoretinal Surgery

    106. Primary Vitrectomy in Rhegmatogenous Retinal Detachment

    107. Pneumatic Retinopexy

    108. Special Adjuncts to Treatment

    109. Optimal Procedures for Retinal Detachment Repair

    110. Prevention of Retinal Detachment


    Section 3: Complicated Forms of Retinal Detachment

    111. Proliferative Vitreoretinopathy

    112. Retinotomies and Retinectomies

    113. Giant Retinal Tear 

    114. Surgery for Ocular Trauma: Principles and Techniques of Treatment

    115. Surgery for Proliferative Diabetic Retinopathy

    116. Management of Combined Inflammatory and Rhegmatogenous Retinal Detachment

    117. High Myopia and the Vitreoretinal Complications

    118. Surgical Management of Retinopathy of Prematurity

    119. Surgery for Pediatric Vitreoretinal Disorders


    Section 4: Vitreous Surgery for Macular Disorders

    120. Epiretinal Membranes, Vitreoretinal Traction and Cystoid Macular Edema

    121. Macular Hole

    122. Surgical Management of Choroidal Neovascularization and Subretinal Hemorrhage

    123. 360 Degree Macular Translocation

    124. Retinal Pigment Epithelium and Choroid Translocation in Patients with Age-Related Macular Degeneration


    Section 5: Vitreous Surgery: Additional Considerations

    125. Infectious Endophthalmitis

    126. Diagnostic and Therapeutic Vitrectomy for Uveitis

    127 . Vitreous, Retinal, and Choroidal Biopsy

    128. Transplantation Frontiers

    129 . Artificial Vision

    130. Pharmacology During Surgery

    131. Complications In Vitreoretinal Surgery


    Tumors of the Retina, Choroid, and Vitreous

    Section 1: Tumors of the Retina

    132. Retinoblastoma

    133. Cavernous Hemangioma

    134. Capillary Hemangioblastoma of the Retina and von Hippel-Lindau Disease

    135. Tuberous Sclerosis and the Eye

    136. Phakomatoses

    137. Retinal Metastases

    138. Remote Effects of Cancer on the Retina

    139. Melanocytoma of the Optic Disc

    140. Congenital Hypertrophy of the Retinal Pigment Epithelium

    141. Combined Hamartoma of the Retinal Pigment Epithelium and Retina


    Section 2: Tumors of the Choroid

    142. Choroidal Nevi

    143. Epidemiology of Posterior Uveal Melanoma

    144. Prognosis of Posterior Uveal Melanoma

    145. Molecular Genetics of Choroidal Melanoma

    146. Pathology of Choroidal Melanoma

    147. Overview of Management of Posterior Uveal Melanoma

    148. Enucleation for Choroidal Melanomas

    149. Brachytherapy for Choroidal Melanoma

    150. Charged-Particle Irradiation of Uveal Melanoma

    151. Surgical Resection of Choroidal Melanoma

    152. Laser Treatment of Choroidal Melanoma

    153. Systemic Evaluation and Management of Patients with Metastatic Uveal Melanoma

    154. Collaborative Ocular Melanoma Study

    155. Choroidal Metastases

    156. Choroidal Osteoma

    157. Circumscribed Choroidal Hemangioma


    Section 3: Hematologic and Miscellaneous Tumors

    158. Miscellaneous Uveal Tumors

    159. Leukemias and Lymphomas

    160. Primary Vitreoretinal Lymphoma

Product details

  • No. of pages: 2976
  • Language: English
  • Copyright: © Elsevier 2017
  • Published: April 17, 2017
  • Imprint: Elsevier
  • eBook ISBN: 9780323401982

About the Editor in Chief

Andrew Schachat

Affiliations and Expertise

Vice Chairman, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH, USA

About the Authors

Charles Wilkinson

Affiliations and Expertise

Chairman, Department of Ophthalmology, Greater Baltimore Medical Center; Professor, Department of Ophthalmology, John Hopkins University, Baltimore, MD, USA

David Hinton

Affiliations and Expertise

Gavin S. Herbert Professor of Retinal Research; Professor of Pathology and Ophthalmology, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

SriniVas Sadda

Affiliations and Expertise

President & Chief Scientific Officer, Doheney Eye Institute, Los Angeles, CA

Peter Wiedemann

Dr. Peter Wiedemann is Professor of Ophthalmology at Leipzig University. He is a vitreoretinal specialist whose expertise includes complex vitreoretinal surgery and macular disorders. Dr. Wiedemann earned his medical degree at Erlangen University, Germany. He started ophthalmic research at the Doheny Eye Institute, Los Angeles, with Dr. Stephen Ryan and completed residency and fellowship in ophthalmology at Cologne University with Prof. Klaus Heimann. In his research Dr. Wiedemann studies retinal and macular disorders and Müller cells pathophysiology. He has authored over 500 peer reviewed publications in ophthalmology and is co-editor of the textbook Ryan´s Retina. He is a member of the German National Academy of Sciences Leopoldina, the German Ophthalmological Society, the American Academy of Ophthalmology and the Club Jules Gonin. He is also a Fellow of the Academia Ophthalmologica Internationalis (AOI), the European Academy of Ophthalmology, and a Board Member of the International Council of Ophthalmology (ICO).

Affiliations and Expertise

Head of the Department of Ophthalmology and Eye Hospital, Medical Faculty, University of Leipzig, Leipzig, Germany

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