Role of Tumor Microenvironment in Breast Cancer and Targeted Therapies

1st Edition - August 10, 2022
Author: Manzoor Ahmad Mir
Language: English
Paperback ISBN:
9 7 8 - 0 - 4 4 3 - 1 8 6 9 6 - 7
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 8 6 9 7 - 4

Role of Tumor Microenvironment in Breast Cancer and Targeted Therapies discusses the current understanding of breast cancer tumor microenvironment components, their role in tumori… Read more

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Role of Tumor Microenvironment in Breast Cancer and Targeted Therapies discusses the current understanding of breast cancer tumor microenvironment components, their role in tumorigenicity and the development of therapeutic resistance, along with updates on recent advances.

Cover image
Title page
Table of Contents
Copyright
Contributors
Preface
Chapter 1: Introduction to various types of cancers
Abstract
1.1: Introduction
1.2: Tissue homeostasis and the progression of cancer
1.3: Major types of cancer
1.4: Summary
References
Chapter 2: The tumor microenvironment
Abstract
2.1: Introduction
2.2: Important players in the breast cancer immune microenvironment
2.3: Immunosuppressive cells
2.4: Tumor microenvironment-targeting therapeutics
2.5: Summary
References
Chapter 3: Role of cancer-associated fibroblasts in tumor microenvironment
Abstract
3.1: Introduction
3.2: An overview of cancer-associated fibroblasts
3.3: Heterogeneity of CAFs
3.4: CAFs’ activation mechanism
3.5: Role of CAFs
3.6: CAF–immune microenvironment interaction in tumors
3.7: Challenges and directions
3.8: Conclusion
References
Chapter 4: Role of mesenchymal stem cells in tumor microenvironment
Abstract
4.1: Introduction
4.2: MSC phenotype and origin
4.3: Homing to the tumor microenvironment
4.4: Functions in the tumor microenvironment
4.5: MSCs exosomes therapy in tumors
4.6: MSC crosstalk with immune components of the inflammatory niche in solid cancer
4.7: Perinatal MSC as therapeutic strategy in cancer
4.8: Conclusion
References
Chapter 5: Role of regulatory T cells in cancer
Abstract
5.1: Introduction
5.2: Different subgroups of T regulatory cells
5.3: Immunosuppressive potential of T regulatory cells and cancer
5.4: T regulatory cell infiltration in tumor microenvironment
5.5: Regulatory T-cell antigen specificity in cancer
5.6: Role of regulatory T cells in cancer
5.7: Cancer vaccines and regulatory T cells
5.8: Targeting T regulatory cells in cancer therapy
5.9: Conclusion
References
Further reading
Chapter 6: Role of tumor-associated macrophages in the breast tumor microenvironment
Abstract
6.1: Introduction
6.2: Composition
6.3: Macrophages in the tumor microenvironment
6.4: Recruitment of monocytes and macrophages to breast tumors
6.5: Differentiation and maturation of TAMs in breast tumors
6.6: Relative numbers of macrophages in breast cancer progression
6.7: Location of macrophages in breast tumors
6.8: Breast cancer cell metastasis
6.9: Breast cancer angiogenesis
6.10: TAMs promote breast cancer cell stemness
6.11: Clinical significance of TAMs in breast tumors
6.12: Preclinical evidence for a role of TAMs in breast cancer treatment resistance
6.13: Conclusion
References
Further reading
Chapter 7: Role of Tumor-associated neutrophils in the breast tumor microenvironment
Abstract
7.1: Introduction
7.2: Immunity and cancer
7.3: Cells associated with breast cancer
7.4: Neutrophils and cancer
7.5: Factors affecting recruitment of TANs into the tumor
7.6: Mechanism behind TANs
7.7: Summary
References
Chapter 8: The extracellular matrix in breast cancer
Abstract
8.1: Introduction
8.2: The breast tissue's ECM architecture
8.3: ECM changes as breast cancer progresses
8.4: Rigidity of the ECM and tumor development
8.5: In morphological breast tumor subtypes, ECM dynamics are studied
8.6: The dynamics of the ECM in molecular breast tumor subtypes
8.7: Mechanosignaling changes
8.8: Immune system changes
8.9: Vasculature changes
8.10: ECM and metastasis
8.11: Stromal remodeling is required for metastasis
8.12: Treatment resistance mediated by ECM
8.13: Limiting the entry of drugs
8.14: Resistance mediated through contact
8.15: Hypoxia and stemness levels are both on the rise
8.16: Dormancy induction
8.17: ECM remodeling as a result of treatment
8.18: The role of enzymes in ECM remodeling
8.19: The ECM of tumors can be targeted therapeutically
8.20: Conclusion
References
Chapter 9: Breast cancer stem cells and their role in tumor microenvironment
Abstract
9.1: Introduction
9.2: Origin of BCSCs
9.3: Breast cancer markers and targeted pathways involved in stem cell-mediated breast cancer progression
9.4: BCSCs and associated cellular markers
9.5: BCSCs and associated signaling pathways
9.6: BCSCs as a predictive marker
9.7: BCSC metabolism and tumor microenvironment
9.8: BCSCs targeting in therapy resistance and drug development
9.9: BCSCs: Current developments and therapeutic significance
9.10: Summary
References
Further reading
Chapter 10: Targeting tumor microenvironment for breast cancer treatment
Abstract
10.1: Introduction
10.2: Tumor microenvironment—A suitable target for treating breast cancer
10.3: Chemotherapy and tumor microenvironment
10.4: Therapies that aim at the TME
10.5: Radiotherapy and tumor microenvironment
10.6: Nanochemotherapeutics and tumor microenvironment
10.7: Summary
References
Index

Manzoor Ahmad Mir

Dr. Manzoor Ahmad Mir holds Master’s Degree in Zoology from HNBG Central University and after qualifying prestigious National level CSIR-JRF-NET examination he worked jointly for his Ph. D at Jawaharlal Nehru University New Delhi and CSIR-Institute of Microbial Technology Chandigarh in the field of Immunology. His basic research interests include Cancer Biology, Combination therapy in Breast Cancer, molecular immunology and Tuberculosis immunology. He has published more than 50 high-impact research papers and book chapters, in recognition of which he has received several awards and Royalties from international publishing houses. Dr. Manzoor has authored more than 15 books with international publishers like Elsevier USA and Nova Science Publisher USA, Bentham Sciences, IGI Global, Springer-Nature. He is on the editorial board and Reviewer of some prestigious journals like DOVE medical press, Springer Plus, Cancer Biomarkers, Frontiers, Plos etc and has been an invited speaker at various scientific meetings/conferences within India and abroad. He is member of many scientific organizations and societies like American Association of Cancer Research, Fellow of Royal British Society, International Immunology Association, Indian Cancer Society, Indian Immunology Society, Indian National Science Association, IMMUNOCON etc. Dr Manzoor was awarded Teachers Associate Research Excellence Fellowship (TARE) by DST Govt of India. He has been awarded Summer Research Fellowship Programme (SRFP-2019) by Indian Academy of Sciences and National Science Academy. He was awarded a research project on combination therapy in breast cancer by J&K Science Technology and Innovation. Dr Manzoor has developed Massive Open Online Course (MOOCs) in Immunology course and Endocrinology course for UG students sanctioned by UGC-Consortium for Educational Communication (CEC) SWAYAM Ministry of HRD Govt of India. He has research and teaching experience of 15 years. He currently teaches Cancer Biology, and Immunology at the Department of Bioresources, School of Biological Sciences, University of Kashmir. He is presently heading the Department of Bioresources, University of Kashmir.

Affiliations and expertise

Department of Bioresources, School of Biological Sciences, University of Kashmir, Srinagar, India