Role of Inflammation in Environmental Neurotoxicity

Role of Inflammation in Environmental Neurotoxicity

1st Edition - January 22, 2019

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  • Editors: Michael Aschner, Lucio Costa
  • eBook ISBN: 9780128157183
  • Paperback ISBN: 9780128157176

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Role of Inflammation in Environmental Neurotoxicity, Volume Three, in this comprehensive serial, addresses contemporary advances in neurotoxicology by providing authoritative review articles on key issues in the field. Edited by leading subject experts, topics of note in this new release include Neuroinflammation (Introduction), Organophosphates, Lead, Manganese, Drugs of abuse, Peripheral vs central inflammation, Air pollution, Developmental neurotoxicity, Ethanol, and the Blood brain barrier, amongst other topics.

Key Features

  • Provides a unique, first of its kind resource
  • Contributed to by world leaders in neurotoxicology
  • Contains a diversity of topics (from molecular to epidemiology) in neurotoxicology


Academic researchers, research scientists and graduate students in universities and in industry

Table of Contents

  • 1. An Introduction to Innate Immunity in the Central Nervous System
    Gaylia Jean Harry
    2. Neuroinflammation in Organophosphate-Induced Neurotoxicity
    Pamela J. Lein
    3. Neuroimmunotoxicology of The Heavy Metal Toxicant Lead
    David Lawrence
    4. The Role of Manganese in Neuroinflammation
    Anumantha G. Kanthasamy
    5. Inflammatory Mechanisms of Abused Drugs
    Bryan Yamamoto
    6. Overview of Peripheral and Central Inflammatory Responses and their Contribution to Neurotoxicity
    Nick Filipov
    7. Neurotoxicity of Air Pollution: Role of Neuroinflammation
    L. Costa and Lucio G. Costa
    8. The role of neuroinflammation in developmental neurotoxicity, tackling complexity in children’s exposures and outcomes
    Amedeo D'Angiulli
    9. Role of Neuroinflammation in Ethanol Neurotoxicity
    Consuelo Guerri
    10. Blood-Brain Barrier at the Interface of Air pollution-Associated Neurotoxicity and Neuroinflammation
    Matthew J. Campen

Product details

  • No. of pages: 351
  • Language: English
  • Copyright: © Academic Press 2019
  • Published: January 22, 2019
  • Imprint: Academic Press
  • eBook ISBN: 9780128157183
  • Paperback ISBN: 9780128157176

About the Serial Editors

Michael Aschner

Michael Aschner
Dr. Aschner serves as the Harold and Muriel Block Chair in Molecular Pharmacology at Albert Einstein College of Medicine. He served on numerous toxicology panels (Institute of Medicine, US Environmental Protection Agency, Center for Disease Control), and is a member of the Neurotoxicology and Alcohol study section (NIH). Research in our lab focuses on the following topics: (1) Modulation of C. elegans genes (aat, skn-1, daf-16) that are homologous to mammalian regulators of MeHg uptake and cellular resistance will modify dopaminergic neurodegeneration in response to MeHg exposure. (2) Under conditions of MeHg-induced oxidative stress, Nrf2 (a master regulator of antioxidant responses) coordinates the upregulation of cytoprotective genes that combat MeHg-induced oxidative injury, and that genetic and biochemical changes that negatively impact upon Nrf2 function increase MeHg’s neurotoxicity. (3) PARK2, a strong PD genetic risk factor, alters neuronal vulnerability to modifiers of cellular Mn status, particularly at the level of mitochondrial dysfunction and oxidative stress. Our studies are designed to (1) shed novel mechanistic insight into metal-induced neurodegeneration; (2) identify targets for genetic or pharmacologic modulation of neurodegenerative disorders; (3) increase knowledge of the pathway involved in oxidative stress; (4) develop improved research models for human disease using knowledge of environmental sciences.

Affiliations and Expertise

Professor, Department of Molecular Pharmacology, Albert Einstein College of Medicine, NY, USA

Lucio Costa

Lucio Costa
Dr. Lucio G. Costa is Professor of Toxicology at the University of Washington in Seattle, and of Pharmacology/Toxicology at the University of Parma Medical School. He received a doctorate in Pharmacology from the University of Milano in 1977, and was a postdoctoral fellow at the University of Texas at Houston. He is a member of several national and international professional organizations, a Fellow of the Academy of Toxicological Sciences, and a European Certified Toxicologist. He received various award for his scientific accomplishments, including the Achievement Award from the Society of Toxicology. He serves in various editorial capacities for several toxicology journals, and is an active manuscript and grant reviewer. Dr. Costa has been the member of dozens of panels and committees at the national and international level dealing with toxicology and risk assessment issues. He has chaired and/or organized symposia at scientific meetings in the United States and internationally. He has been teaching classes in the area of toxicology, neurotoxicology and pharmacology to graduate and medical students for 30 years. He keeps an active research program in the area of neurotoxicology.

Affiliations and Expertise

Professor of Toxicology, University of Washington, Seattle, WA, USA

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