1st Edition - January 28, 1984

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  • Author: Morris Green
  • eBook ISBN: 9780323140461

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The Role of the Gastrointestinal Tract in Nutrient Delivery contains the proceedings of the third annual Bristol-Myers Symposium on Nutrition Research, held on December 1-2, 1983 in Washington, D.C. Contributors focus on the knowledge and research findings concerning the role of the gastrointestinal tract in nutrient delivery. This text is organized into 15 chapters and addresses topics such as gastrointestinal motility; hormonal regulation of growth and function; the mechanisms of digestion and absorption; and the diverse effects of intestinal contents on nutrient absorption and antigenic response. The discussion begins with an overview of the gastrointestinal tract, with emphasis on factors that affect the growth of gastrointestinal mucosa and the implications for nutrition. This book then turns to kinetic and biochemical parameters related to the development of several diseases of the gastrointestinal tract. The reader is also introduced to the basic aspects of organization of the systems in which peptides act as regulators of digestion; the role of endogenous prostaglandins in the gastrointestinal tract; and gastric secretion. A chapter on the age-related functions of digestive tract organs concludes the book. This book will be of value to physicians and scientists as well as students and researchers who have an interest in the crucial role of the gastrointestinal tract in converting food into the nutrients the body uses to sustain its functions.

Table of Contents

  • Contents


    Editor's Foreword



    1 Regulation of Gastrointestinal Growth

    I. Introduction

    II. Trophic Action of Gastrointestinal Hormones: Physiological Significance

    III. Characteristics of Gastrin's Trophic Action

    IV. Mucosal Gastrin Receptor

    V. Summary


    2 Proliferation and Differentiation of Gastrointestinal Cells in Health and Disease

    I. Introduction

    II. Location of Proliferating and Differentiating Cells

    III. Proliferation Kinetics of Normal Cells

    IV. Proliferation Kinetics of Cells in Disease


    3 Regulatory Peptides of the Gut

    I. Introduction

    II. Cellular Organization of Gut Peptide Control Systems

    III. Chemical Identification, Characterization, and Biosynthesis

    IV. Hormonal Mechanisms

    V. Enteric Peptide-Producing Neurons

    VI. Perspectives


    4 Prostaglandins in Relation to the Gastrointestinal Tract

    I. Introduction

    II. Biosynthesis in Gastrointestinal Tissue

    III. Gastric Antisecretory Actions

    IV. Gastric Vasodilator Actions

    V. Gastrointestinal Antiulcer and Protective Properties

    VI. Prostaglandin Depletion and Gastric Damage

    VII. Intestinal Motility and Secretion

    VIII. Role in Inflammatory Bowel Disease

    IX. Conclusions


    5 Gastrointestinal Motility: The Regulation of Nutrient Delivery

    I. Introduction

    II. Mucosal Muscle Movements in the Small Intestine

    III. Movements of the Muscularis Propria in the Small Intestine

    IV. Movements of the Muscularis Propria of the Stomach

    V. Movements of the Muscularis Propria of the Esophagus

    VI. Some Motor Disorders That Impair Nutrient Delivery


    6 Gastric Secretion

    I. Functional Anatomy of the Stomach

    II. Physiological Regulation of Human Gastric Secretion

    III. Summary


    7 Small Intestinal Absorption and Secretion in Health and Disease

    I. Introduction

    II. Sodium-Coupled Absorption of Water-Soluble Nutrients

    III. Intestinal Secretion

    IV. Fluid Absorption and Secretion in Health and Disease


    8 Carbohydrate Absorption and Malabsorption

    I. Introduction

    II. Intraluminal Digestion of Starch

    III. Intestinal Membrane Digestion of Oligosaccharides

    IV. Mechanisms of Digestion for Glucose, Galactose, and Fructose

    V. Rate-Limiting Steps in Digestion and Absorption

    VI. Maldigestion and Malabsorption

    VII. Summary


    9 Fat Absorption and Malabsorption

    I. Introduction

    II. Intraluminal Digestion

    III. Role of Bile Salts in Intraluminal Absorption

    IV. Mucosal Phase of Absorption

    V. Intestinal Lipoproteins


    10 Integration of Energy Metabolism by the Liver

    I. Introduction

    II. General Properties of Metabolism

    III. Unique Metabolic Events in the Fed State

    IV. Unique Metabolic Events in the Postabsorptive State

    V. Unique Metabolic Events in the Fasted State

    VI. Hepatic Synthesis of Ketone Bodies

    VII. Influence of Liver Disease on Energy Metabolism


    11 Differences in Metabolic Handling of Orally versus Parenterally Administered Nutrients

    I. Introduction

    II. Utilization of Amino Acids

    III. Utilization of Carbohydrate and Fat

    IV. Utilization of Vitamins and Trace Elements

    V. Purine Metabolism in the Mucosa

    VI. Conclusions


    12 Gut Bacterial Metabolism and Human Nutrition

    I. Introduction

    II. Influence of Human Intestinal Microflora in Nutrition

    III. Summary


    13 Dietary Fiber and Nutrient Delivery

    I. Introduction

    II. Definitions

    III. Functions of Dietary Fiber in Human Physiology

    IV. Dietary Fiber and Disease

    V. Therapeutic Implications

    VI. Summary


    14 Immunology and Allergic Responses of the Bowel

    I. Intestinal Immune System

    II. Food Allergies

    III. Nutrition and the Immune Response

    IV. Altered Immune Function in Intestinal Disease

    V. Summary


    15 Gastrointestinal Function and Aging

    I. Introduction

    II. Function of the Alimentary Organs

    III. Digestion and Absorption of Macronutrients

    IV. Absorption of Micronutrients

    V. Circulatory Events

    VI. Intestinal Morphology

    VII. Conclusion



Product details

  • No. of pages: 290
  • Language: English
  • Copyright: © Academic Press 1984
  • Published: January 28, 1984
  • Imprint: Academic Press
  • eBook ISBN: 9780323140461

About the Author

Morris Green

Affiliations and Expertise

Perry W. Lesh Professor of Pediatrics, Indiana University School of Medicine, James Whitcomb Riley Hospital for Children, Indianapolis, IN

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