RNA Recognition

RNA Recognition

1st Edition - June 23, 2019

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  • Editor: Amanda Hargrove
  • Hardcover ISBN: 9780128168318
  • eBook ISBN: 9780128168325

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RNA Recognition, Volume 623, the latest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This updated volume covers a variety of topics, including The Preparation of cooperative RNA recognition complexes for crystallographic structural studies, Methods for thermal denaturation studies of fluorogenic aptamers, Dynamic combinatorial chemistry as a rapid, fragment-based approach to RNA-targeted compound discovery, Using a click chemistry assay to identify natural product ligands for pre-microRNAs, Lessons from exploration of chemical and structural small molecule:RNA space, Using ligand-observed NMR to study RNA-small molecule interactions, and much more.

Key Features

  • Provides the authority and expertise of leading contributors from an international board of authors
  • Presents the latest release in the Methods in Enzymology series
  • Includes the latest information on RNA Recognition


Biochemists, biophysicists, molecular biologists, analytical chemists, and physiologists

Table of Contents

  • 1. Preparation of cooperative RNA recognition complexes for crystallographic structural studies
    Chen Qiu, Aaron C. Goldstrohm and Traci M. Tanaka Hall
    2. Methods for thermal denaturation studies of nucleic acids in complex with fluorogenic dyes
    Lauren M. Aufdembrink, Tanner G. Hoog, Matthew R. Pawlak, Benjamin F. Bachan, Joseph M. Heili and Aaron E. Engelhart
    3. Identifying and validating small molecules interacting with RNA (SMIRNAs)
    Matthew D. Disney, Sai Pradeep Velagapudi, Yue Li, Matthew G. Costales and Jessica L. Childs-Disney
    4. Dynamic combinatorial chemistry as a rapid method for discovering sequence-selective RNA-binding compounds
    John D. McAnany and Benjamin L. Miller
    5. A click chemistry assay to identify natural product ligands for pre-microRNAs
    Amanda L. Garner, Daniel A. Lorenz and Erin E. Gallagher
    6. Differentiation and classification of RNA motifs using small molecule-based pattern recognition
    Giacomo Padroni, Christopher S. Eubanks and Amanda E. Hargrove
    7. Ligand-observed NMR techniques to probe RNA-small molecule interactions
    David R. Calabrese, Colleen M. Connelly and John S. Schneekloth Jr.
    8. Synthetic bPNAs as allosteric triggers of hammerhead ribozyme catalysis
    Yufeng Liang, Jie Mao and Dennis Bong
    9. Using Rosetta for RNA homology modeling
    Andrew Watkins, Ramya Rangan and Rhiju Das
    10. Monitoring co-transcriptional folding of riboswitches through helicase unwinding
    Christopher P. Jones, Subrata Panja, Sarah A. Woodson and Adrian R. Ferré-D’Amaré
    11. Strategies for understanding RNA recognition by X-ray and NMR methods
    Aiai Sun, Kaiyi Huang, Luqian Zheng and Aiming Ren
    12. Sensitive detection of structural features and rearrangements in long, structured RNA molecules
    Rebecca L. Adams, Nicholas C. Huston, Rafael C.A. Tavares and Anna M. Pyle
    13. A fluorescent aminosugar to rapidly screen and study RNA binders
    Nihar Ranjan and Dev P. Arya
    14. The use of electrospray ionization mass spectrometry to monitor RNA-ligand interactions
    Danielle N. Dremann and Christine S. Chow
    15. Design of RNA-targeting macrocyclic peptides
    Matthew J. Walker and Gabriele Varani
    16. Molecular recognition of HIV-1 RNAs with branched peptides
    Ashley N. Peralta, Yumin Dai, Chringma Sherpa, Stuart F.J. Le Grice and Webster L. Santos
    17. Sequence-specific recognition of structured RNA by triplex-forming peptide nucleic acids
    Dziyana Hnedzko and Eriks Rozners
    18. Evaluating riboswitch optimality
    Hannah Wayment-Steele, Michelle Wu, Michael Gotrik and Rhiju Das

Product details

  • No. of pages: 468
  • Language: English
  • Copyright: © Academic Press 2019
  • Published: June 23, 2019
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128168318
  • eBook ISBN: 9780128168325

About the Serial Volume Editor

Amanda Hargrove

Amanda E. Hargrove is at Duke University, USA

Affiliations and Expertise

Duke University, USA

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