RNA Modification

RNA Modification

1st Edition - June 9, 2017

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  • Editor: Fuyuhiko Tamanoi
  • Hardcover ISBN: 9780128117774
  • eBook ISBN: 9780128117781

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Description

RNA Modification, Volume 41 examines the powerful ability to regulate the function of RNA molecules or modify the message transmitted by RNA molecules. Chapters in this newly released volume include The Importance of Being Modified: Modifications Shape RNA Function through Chemistry, Structure and Dynamics, The evolution of multi-substrate specificity by RNA modification enzymes, TrmD: a methyl transferase for tRNA methylation with m1G37, Structures and activities of the Elongator complex and its co-factors, RNA pseudouridylation: Mechanism and Function, The activity of 5’3' exonucleases on hypo modified tRNA substrates and other structured RNAs, and the Synthesis, heterogeneity and function of post-transcriptional nucleotide modifications in eukaryotic ribosomal RNAs. This field has recently seen a very rapid progress in the understanding of the mechanism and enzymes involved in RNA modification. This volume presents some of the most recent advances in the identification and function of enzymes involved in modifying RNA molecules.

Key Features

  • Features authoritative expertise from recognized contributors to the field
  • Presents the most recent advances in the rapidly evolving field of RNA modification
  • Covers the identification and function of enzymes involved in modifying RNA molecules

Readership

Researchers interested in gene expression regulatory mechanisms and epigenetics; students and professors who learn or teach molecular genetics, molecular and cellular biology

Table of Contents

  • 1. The Importance of Being Modified: Modifications Shape RNA Function through Chemistry, Structure and Dynamics
    Paul F. Agris
    2. The evolution of multi-substrate specificity by RNA modification enzymes
    Juan Alfonzo
    3. TrmD: a methyl transferase for tRNA methylation with m1G37
    Ya-Ming Hou
    4. Structures and activities of the Elongator complex and its co-factors
    Bertrand Séraphin
    5. RNA pseudouridylation: Mechanism and Function
    Yi-Tao Yu
    6. the activity of 5’3' exonucleases on hypo modified tRNA substrates and other structured RNAs
    Eric Phizicky
    7. Synthesis, heterogeneity and function of post-transcriptional nucleotide modifications in eukaryotic ribosomal RNAs
    Anthony Henras
    8. Adenosine Deaminases acting on RNA (ADARs
    Peter Beal
    9. Modifying the message: computational and experimental techniques for mapping the mRNA epitranscriptome
    Brian Gregory

Product details

  • No. of pages: 342
  • Language: English
  • Copyright: © Academic Press 2017
  • Published: June 9, 2017
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128117774
  • eBook ISBN: 9780128117781

About the Serial Editor

Fuyuhiko Tamanoi

Fuyu Tamanoi is a biochemist who has served on the UCLA School of Medicine and UCLA College faculty since he joined the Department of Microbiology, Immunology & Molecular Genetics in 1993. He became a full professor in 1997.

Affiliations and Expertise

Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, USA

About the Serial Volume Editor

Guillaume Chanfreau

Dr Guillaume Chanfreau obtained his Bachelor Degree from Université Claude Bernard Lyon and ENS Lyon and his PhD in Microbiology from Université Paris VI. During his PhD, mentored by Alain Jacquier, he characterized the mechanism of splicing of group II intron ribozymes. Dr Chanfreau then completed postdoctoral training at UCSF with Christine Guthrie, where he identified novel factors involved in 3’-end processing of mRNAs and small RNAs. After this postdoctoral training, he was recruited at UCLA as a professor in the Department of Chemistry and Biochemistry where he teaches a Biochemistry upper division course focused on DNA, RNA and protein synthesis. At UCLA, Dr Chanfreau has developed a research program focused on understanding the mechanisms of RNA degradation and RNA processing, and how these processes contribute to regulate gene expression.

Affiliations and Expertise

University of California, Los Angeles, USA

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