RNA-Based Regulation in Human Health and Disease

CHAPTER 1 Introduction
CHAPTER 2 Non-coding RNAs: ever-expanding diversity of types and functions
CHAPTER 3 Functional categories of RNA regulation
CHAPTER 4 The dynamic aspects of RNA regulation
CHAPTER 5 RNA beyond humans
CHAPTER 6 Extracellular RNA in human health and disease
CHAPTER 7 RNA and malaria pathogenesis
CHAPTER 8 RNA and metabolic disorders
CHAPTER 9 RNA toxicity in tandem nucleotide repeats mediated neurodegenerative disorders
CHAPTER 10 Regulation by non-coding RNAs in respiratory disorders
CHAPTER 11 RNA in cancer
CHAPTER 12 RNA and inflammatory autoimmune diseases
CHAPTER 13 RNA and bacterial infection
CHAPTER 14 RNA and stress
CHAPTER 15 RNA and aging
CHAPTER 16 Experimental toolkit to study RNA level regulation
CHAPTER 17 Industry perspective
CHAPTER 18 Summary and future perspectives

RNA-based Regulation in Human Health and Disease offers an in-depth exploration of RNA mediated genome regulation at different hierarchies. Beginning with multitude of canonical and non-canonical RNA populations, especially noncoding RNA in human physiology and evolution, further sections examine the various classes of RNAs (from small to large noncoding and extracellular RNAs), functional categories of RNA regulation (RNA-binding proteins, alternative splicing, RNA editing, antisense transcripts and RNA G-quadruplexes), dynamic aspects of RNA regulation modulating physiological homeostasis (aging), role of RNA beyond humans, tools and technologies for RNA research (wet lab and computational) and future prospects for RNA-based diagnostics and therapeutics. One of the core strengths of the book includes spectrum of disease-specific chapters from experts in the field highlighting RNA-based regulation in metabolic & neurodegenerative disorders, cancer, inflammatory disease, viral and bacterial infections. We hope the book helps researchers, students and clinicians appreciate the role of RNA-based regulation in genome regulation, aiding the development of useful biomarkers for prognosis, diagnosis, and novel RNA-based therapeutics.

• Comprehensive information of non-canonical RNA-based genome regulation modulating human health and disease
• Defines RNA classes with special emphasis on unexplored world of noncoding RNA at different hierarchies
• Disease specific role of RNA - causal, prognostic, diagnostic and therapeutic
• Features contributions from leading experts in the field

Clinician-scientists; Human Geneticists; Medical Geneticists; Researchers and students working in genetics, biology, molecular biology, pharmaceutical science, oncology, cardiology, psychiatry, neurology, neuroscience, metabolic disorders, inflammatory and infectious disease, internal medicine, and clinical therapy; advanced undergraduate students, graduate students; pharmaceutical company and biotechnology researchers interested in drug development and therapies