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Risk Factors for Psychosis - 1st Edition - ISBN: 9780128132012, 9780128132029

Risk Factors for Psychosis

1st Edition

Paradigms, Mechanisms, and Prevention

Editors: Andrew Thompson Matthew Broome
Paperback ISBN: 9780128132012
eBook ISBN: 9780128132029
Imprint: Academic Press
Published Date: 25th February 2020
Page Count: 456
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Risk Factors for Psychosis: Paradigms, Mechanisms, and Prevention combines the related, but disparate research endeavors into a single text that considers all risk factors for psychosis, including biological, psychological and environmental factors. The book also introduces the ethics and current treatment evidence that attempts to ameliorate risk or reduce the number of individuals with risk factors developing a psychotic disorder. Finally, the book highlights new research paradigms that will further enhance the field in the future.

Psychotic disorders affect more than 50 million people worldwide, creating a devastating effect on lives and causing major financial and emotional impact on families and on society as a whole. The search for risk factors for psychosis has developed rapidly over the past decades, invigorated by changes in the thinking about the malleability and treatability of psychotic disorders. The paradigms for investigating psychosis risk have developed, often in parallel, but there has been no book to date that has summarized and synthesized the current approaches.

Key Features

  • Integrates research from biological, psychological and environmental factors into a single resource
  • Offers insight into at-risk paradigms, biomarkers, and the current state of research on treatment option for psychosis
  • Presents a holistic and dynamic look at risk syndromes and how they can be measured through neuroimaging, neuropsychology and other methods


Advanced students, postgraduate students, researchers, and clinicians in neuroscience, biological psychiatry, and psychology

Table of Contents

1. Historical perspectives on psychosis risk
2. Risk, screening and prevention in psychosis and psychiatry
3. Risk for schizophrenia and the schizophrenia prodrome
4. The At-Risk Mental and Psychosis Risk Syndrome
5. Basic symptoms and self-disturbance
6. Schizotypy and schizotypal personality disorder
7. Genetic high risk and genetic high-risk studies
8. Psychotic-Like Symptoms in the general population
9. Imaging and risk for psychosis
10. Genes and risk
11. Risk and Potential Biomarkers
12. Neurochemical models of risk and onset
13. Clinical factors related to risk
14. Neuropsychological risk factors for psychosis
15. The environment and psychosis risk
16. Ethical issues of identifying and treating psychosis risk
17. Indicated prevention in psychosis risk
18. Population interventions to reduce risk
19. New paradigms to study psychosis risk
20. "At risk for what" - Psychosis risk and Youth Mental Health


No. of pages:
© Academic Press 2020
25th February 2020
Academic Press
Paperback ISBN:
eBook ISBN:

About the Editors

Andrew Thompson

Dr Andrew Thompson is a Principal Research Fellow and Associate Professor at Orygen, the Centre for Youth Mental Health at the University of Melbourne, Australia. He is the lead psychiatrist for the EPPIC early psychosis service and the National headspace Early Psychosis program in Australia and is currently head of clinical psychosis research at Orygen. He also retains a position as Associate Professor at the University of Warwick in the UK. Andrew trained in medicine at the University of Oxford and London and in psychiatry in Nottingham and Bristol. He has an MD in clinical psychiatry from the University of London. He has worked in early psychosis practice and research for over 15 years in both the UK and Australia. He was previously clinical lead for the PACE at risk for psychosis clinic in Melbourne and has been involved in a number of research projects through this clinic and through his work at the University of Bristol and the University of Warwick. Andrew’s research interests include clinical risk factors for the development of psychosis and psychotic symptoms, novel treatments (including technology) in emerging or early psychosis, predictors of outcome in early psychosis and systems of care and prevention approaches in youth mental health.

Affiliations and Expertise

Principal Research Fellow and Associate Professor at Orygen, the Centre for Youth Mental Health at the University of Melbourne, Australia

Matthew Broome

Dr Matthew Broome is a Senior Clinical Research Fellow at the Department of Psychiatry, University of Oxford, and a Consultant Psychiatrist at the Early Intervention in Psychosis Service, Oxford. He trained in medicine at the University of Birmingham and in Psychiatry at the Maudsley hospital (where he worked at the at risk for psychosis clinic (OASIS). He has previously been a Lecturer at the Institute of Psychiatry and an Associate Clinical Professor at The University of Warwick. He has previously edited books on subjects such as phenomenology and the interface between psychiatry and philosophy and has published over 100 research papers mostly relating to at risk for psychosis groups.

Affiliations and Expertise

Senior Clinical Research Fellow, Department of Psychiatry, University of Oxford, UK

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