Risk Assessment for Human Metal Exposures - 1st Edition - ISBN: 9780128042274

Risk Assessment for Human Metal Exposures

1st Edition

Mode of Action and Kinetic Approaches

Authors: Gunnar Nordberg Bruce Fowler
Paperback ISBN: 9780128042274
Imprint: Academic Press
Published Date: 1st September 2018
Page Count: 320
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Risk Assessment for Human Metal Exposures: Mode of Action and Kinetic Approaches concisely examines the current principles of risk assessment in the area of human metal exposures, with a focus on Mode of Action(MOA), Toxicokinetic and Toxicodynamic (TKTD) considerations, and computer models. Derived from the highly respected Handbook on the Toxicology of Metals, Fourth Edition (2014), the book summarizes principles and methods, providing examples of how MOA –TKTD can be used, and how information generated by such methods can be confirmed by epidemiological data.

Furthermore, it demonstrates how epidemiological data can be confirmed and evaluated by the examined models and considerations.

This resource uniquely integrates several important topics, such as risk assessment, characterization, management and communication – the classic risk assessment paradigm – with mode of action, TKTD, and epidemiology, all related to human exposure. Written by pioneers in the field this book is an essential reference for researchers, students and technicians in toxicology and risk assessment.

Key Features

  • Covers fundamental risk assessment concerns for the effects of metals on human health in a concise volume
  • Provides an easy to use structure to quickly locate specific methods
  • Uses case studies to illustrate the methods and theories described
  • Written to be understood by students, researchers and industry workers who need to conduct risk assessment in metals and human health


Toxicologists, epidemiologists, risk assessors, regulators and societal decision makers. Secondary markets include environmental health researchers and practitioners and the risk science community

Table of Contents

  1. Introduction
    2. Exposure and Internal Dose
    3. Mode of Action (MOA) and Target Dose
    4. Hazard Identification
    5. Dose-Effect and Dose-Response Assessment
    6. Dose-Response for Essential Metals and the Evaluation of Mixed Exposures
    7. Applied Risk assessment
    8. Examples of current Risk Assessments of Human Metal Exposures and the need for MOA TKTD


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© Academic Press 2019
Academic Press
Paperback ISBN:

About the Author

Gunnar Nordberg

Gunnar Nordberg

Dr Gunnar F. Nordberg, MD, PhD, is an emeritus Professor at Umea University, Umea, Sweden, where he served as chairman of the Department of Environmental and Occupational Medicine for many years. He has also worked as a scientist at the International Agency for Research on Cancer, Lyon, France and as a Professor and chairman at the Department of Environmental Medicine, Odense University, Denmark. He has published more than 270 papers in Scientific Journals and International Handbooks. In addition, he edited or co-edited 23 Scientific Books and participated in International Task Groups evaluating Risks of Environmental Agents which resulted in 25 international books. Some of these publications resulted from his activities as a chairman of the Scientific Committee on the Toxicology of Metals, International Commission on Occupational Health. He is presently the Task Group Chairman of Cadmium Risk Assessment in the Toxicology and Risk Assessment Group of the International Union of Pure and Applied Chemistry. His Scientific Publications are mainly on Toxicology and Epidemiology of environmental agents, particularly metals. He has coordinated EU- projects on Environmental Epidemiology and Toxicology of Metals and participated as an active scientist in several such projects. He has been the principal investigator of many research projects funded by Swedish funding Agencies and is presently actively involved in such research. He is one of the editors of a Textbook in Swedish “Arbets- och Miljömedicin”, latest (3rd) Edition 2010. Chief Editor, Handbook on the Toxicology of Metals, 3rd Ed, published 2007 by Academic Press/Elsevier, new 4th edition publishing October 2014. He has extensive experience as an expert serving Swedish and International Authorities such as the Swedish National Board of Health (Socialstyrelsen), Japan Food Safety Agency, US Environmental Protection Agency, National Institute for Environmental Health Studies (NIEHS), Agency for Toxic Substances and Disease Registry (ATSDR) USA, World Health Organization HQ, Geneva/International Program on Chemical Safety; International Agency for Research on Cancer IARC, Lyon, France, World Health Organization, Europe/European Environment Agency, Copenhagen; European Food Safety Authority (EFSA), Parma, Italy.

Affiliations and Expertise

Umeå University, Department of Public Health and Clinical Medicine, Sweden

Bruce Fowler

Bruce Fowler

Dr. Fowler began his scientific career at the National Institute of Environmental Health Sciences prior to becoming Director of the University of Maryland System-wide Program in Toxicology and Professor at the University of Maryland School of Medicine. He then served as Associate Director for Science in the Division of Toxicology and Environmental Medicine at Agency for Toxic Substances and Disease Registry (ATSDR). He is currently a private consultant and Co-owner of Toxicology Risk Assessment Consulting Services (TRACS), LLC. In addition, Dr. Fowler serves as an Adjunct Professor, Emory University Rollins School of Public Health and Presidents Professor of Biomedical Sciences, Center for Alaska Native Health Research (CANHR) at the University of Alaska- Fairbanks. Dr. Fowler, is an internationally recognized expert on the toxicology of metals and has served on a number of State, National and International Committees in his areas of expertise. These include the Maryland Governor’s Council on Toxic Substances (Chair), various National Academy of Sciences / National Research Council Committees, the USEPA Science Advisory Board and Fulbright Scholarship review committee for Scandinavia (Chair, 2000-2001). ). In 2016, he became an Inaugural Member of the Fulbright 1946 Society. He has also served as a temporary advisor to the World Health Organization (WHO) and the International Agency for Research Against Cancer (IARC) for a number of toxicology and risk assessment issues and has been recently appointed as a member of the Joint FAO/WHO Expert Committee on Food Additives (JECFA) for the period 2016-2020. Dr. Fowler has been honored as a Fellow of the Japanese Society for the Promotion of Science (JSPS), a Fulbright Scholar and Swedish Medical Research Council Visiting Professor at the Karolinska Institute, Stockholm, Sweden and elected as a Fellow of the Academy of Toxicological Sciences. His more recent awards include a CDC/ATSDR, Honor Award for Excellence in Leadership Award 2010, The USP Toxicology Committee 2010-2015. The USP Elemental Impurities Panel and the 2014 U.S. Pharmacopea Award for an Innovative Response to Public Health Challenges (Group Award). He was appointed to the USP Nanotechnology Subcommittee in 2015- .Dr. Fowler was previously elected to the Council of the Society of Toxicology (2005-2007), the Board of Directors of the Academy of Toxicological Sciences (2006-2009), and more recently, to the Council of the Society for Risk Analysis (2014-2017He is the Federal Legislative and National Active and Retired Federal Employees Association (NARFE)-PAC Chair for the Rockville Maryland Chapter of NARFE. Dr. Fowler is the current President of the Rotary Club of North Bethesda, Maryland (2016-2017) and was selected as Rotarian of the Year in 2015 for his work in developing a taxi-based program to help persons with disabilities gain independence via reliable transportation to work. Dr. Fowler is the author of over 260 research papers and book chapters dealing with molecular mechanisms of metal toxicity, molecular biomarkers for early detection of metal-induced cell injury and application of computational toxicology for risk assessment. He has been the editor, co-editor or author of 8 books or monographs on metal toxicology and mechanisms of chemical – induced cell injury, molecular biomarkers and risk assessment and computational toxicology. Dr. Fowler is currently focused on the global problem of electronic waste in developing countries. He serves on the editorial boards of a number of scientific journals in toxicology and is an Associate Editor of the journal Toxicology and Applied Pharmacology and a past Associate Editor of Environmental Health Perspectives (2007-2016).

Affiliations and Expertise

Private Consulting Toxicologist, Adjunct Professor, Emory University, Rollins School of Public Health, and Presidents Professor of Biomedical Research, University of Alaska - Fairbanks

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