Retroviruses and Disease

Retroviruses and Disease

1st Edition - April 28, 1989

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  • Editor: Hidesaburo Hanafusa
  • eBook ISBN: 9780323160193

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Retroviruses and Disease presents a relevant summary of the state of knowledge in both human nonhuman retroviruses. It highlights significant concepts regarding their commonalities and differences in terms of retroviral systems. A section of this book covers the pathogenic human retroviruses and focuses on two. These are HLTV-1 (the first human retrovirus that was isolated) and HIV (the cause of a potent immunological disorder). The life cycle of replication-competent retroviruses, including the murine leukemia viruses and its functions, is discussed in Chapters 1 and 2. The focus of the third chapter is the transformation of Rous sarcoma virus. Meanwhile, Chapter 4 discusses the multiple stages in avian leukosis virus-induced B cell lymphoma. Oncogenes, the molecular basis of human cancer, are also covered in this book. Another virus also discussed in this book is the human T cell leukemia virus. The book is a good reference for students, teachers, specialists, scientists, and researchers in microbiology.

Table of Contents

  • Preface

    1. Genetics of Replication of Moloney Murine Leukemia Virus

    I. Introduction

    II. The Life Cycle and Genomic Organization of the Murine Leukemia Viruses

    III. Construction and Analysis of Mutants of Moloney MuLV: Assignment of Function to Retroviral Gene Products

    IV. Summary


    2. Functions of Murine Leukemia Virus Envelope Gene Products in Leukemogenesis

    I. Introduction

    II. Structure and Biosynthesis of MuLV env Gene Products

    III. Cell-Surface Receptors for MuLV env Proteins

    IV. Functional Activities of MuLV env Proteins

    V. Leukemogenicities of Recombinant env Genes

    VI. Structure and Function of the Friend Spleen Focus-Forming Virus (SFFV)

    VII. Possible Mechanistic Roles of MuLV env Proteins in Leukemogenesis

    VIII. Conclusions


    3. Transformation by Rous Sarcoma Virus

    I. Introduction

    II. Activation of Transforming Potential of the Cellular src Proto-oncogene

    III. Cell Transformation by p60v-src


    4. Multiple Stages in Avian Leukosis Virus-Induced B Cell Lymphoma

    I. Introduction

    II. Tumor Progression in ALV-Induced B Cell Lymphoma

    III. Transcriptional Activation of the c-myc Proto-oncogene

    IV. Alterations in the c-myc Gene Product?

    V. Defectiveness of the Provirus

    VI. Activation of Additional Proto-oncogenes

    VII. Summary


    5. From Retroviral to Human Oncogenes: The Molecular Basis of Human Cancer

    I. Introduction

    II. ras Oncogenes

    III. myc Oncogenes

    IV. Oncogene Activation in B and T Cell Tumors

    V. The abl Oncogene and the Philadelphia Chromosome

    VI. Growth Factor Receptors and Human Oncogenes

    VII. New Human Oncogenes

    VIII. Recessive Oncogenes

    IX. Future Perspectives


    6. Retroviral Gene Transfer: Application to Human Therapy

    I. Principles of Retroviral Gene Transfer

    II. Somatic Gene Therapy—the Human ADA Deficiency Model System

    III. Use of Antisense RNA Inhibition to Protect Cells from HTLV-I-Mediated Oncogenic Transformation

    IV. Summary


    7. Models for Mechanisms of Transformation by the Human T Cell Leukemia Viruses

    I. Introduction

    II. Hypotheses for Mechanisms of HTLV



    8. Disorders of IL-2 Receptor Expression in HTLV-I-Associated Adult T Cell Leukemia

    I. Introduction

    II. Chemical Characterization of the Multichain IL-2 Receptor

    III. Molecular Cloning of cDNAs for the Human 55-kDa Tac IL-2 Receptor Peptide

    IV. Distribution of IL-2 Receptors

    V. Lymphocyte Functions That Are Regulated by the Interaction of IL-2 with Its Receptor

    VI. Disorders of IL-2 Expression in Adult T Cell Leukemia

    VII. The IL-2 Receptor as a Target for Therapy in Patients with ATL, Patients with Autoimmune Disorders, and Individuals Receiving Organ Allografts

    VIII. Summary


    9. The Characteristics of an HIV "A" (sor) Gene Mutant



    10. Molecular Aspects of HIV: Mechanisms of Gene Regulation and Immune Evasion

    I. Introduction

    II. Molecular Structure of HIV

    III. Function of the tat and trs Genes

    IV. Mapping of Functional Domains of tat

    V. Regulation of HIV Expression and Pathogenesis

    VI. The HIV Envelope, Infectivity, and Virus Neutralization


    11. Replication and Pathogenesis of HIV-1 Retrovirus Relevant to Drug Design

    I. Controlled Infection

    II. Selective Cytotoxicity

    III. Evasion of the Immune Response

    IV. Summary



Product details

  • No. of pages: 208
  • Language: English
  • Copyright: © Academic Press 1989
  • Published: April 28, 1989
  • Imprint: Academic Press
  • eBook ISBN: 9780323160193

About the Editor

Hidesaburo Hanafusa

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