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Retinoid Signaling Pathways - 1st Edition - ISBN: 9780128201442, 9780128201473

Retinoid Signaling Pathways, Volume 637

1st Edition

Serial Volume Editor: Ehmke Pohl
Hardcover ISBN: 9780128201442
eBook ISBN: 9780128201473
Imprint: Academic Press
Published Date: 29th April 2020
Page Count: 610
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Table of Contents

    1. Vitamin A and its natural derivatives
    2. Chris P.F. Redfern

    3. Post-natal all-trans-retinoic acid biosynthesis
    4. Joseph L. Napoli

    5. Retinoid metabolism and functions mediated by retinoid binding-proteins
    6. Joseph L. Napoli and Hong Sik Yoo

    7. Generation and isolation of recombinant retinoid oxidoreductase complex
    8. Mark K. Adams, Olga V. Belyaeva and Natalia Y. Kedishvili

    9. Sample preparation for structural and functional analyses of the STRA6 receptor for retinol-binding protein
    10. Brianna K. Costabile, Youn-Kyung Kim, Yunting Chen, Oliver B. Clarke, Loredana Quadro and Filippo Mancia

    11. Use of fixatives for immunohistochemistry and their application for detection of retinoic acid synthesizing enzymes in the central nervous system
    12. Azita Kouchmeshky and Peter McCaffery

    13. Classical pathways of gene regulation by retinoids
    14. Ehmke Pohl and Charles W.E. Tomlinson

    15. Protein-protein interactions in the regulation of RAR–RXR heterodimers transcriptional activity
    16. Albane le Maire, Pierre Germain and William Bourguet

    17. Natural ligands of RXR receptors
    18. Patricia García, Paula Lorenzo and Angel R. de Lera

    19. DNA recognition by retinoic acid nuclear receptors
    20. Carole Peluso-Iltis, Judit Osz and Natacha Rochel

    21. Noncanonical retinoic acid signaling
    22. Jennifer Nhieu, Yu-Lung Lin and Li-Na Wei

    23. Retinoic acid and microRNA
    24. Lijun Wang, Atharva Piyush Rohatgi and Yu-Jui Yvonne Wan

    25. Analysis of vitamin A and retinoids in biological matrices
    26. Lindsay C. Czuba, Guo Zhong, King Yabut and Nina Isoherranen

    27. Effects of vitamin A and retinoic acid on mouse embryonic stem cells and their differentiating progeny
    28. Mary Ann Asson-Batres and Christopher W. Norwood

    29. Identifying vitamin A signaling by visualizing gene and protein activity, and by biochemical isolation of vitamin A metabolites
    30. Stephen R. Shannon, Jianshi Yu, Amy E. Defnet, Danika Bongfeldt, Alexander R. Moise, Maureen A. Kane and Paul A. Trainor

    31. Whole mount in situ hybridization and immunohistochemistry for studying retinoic acid signaling in developing amphioxus
    32. Matteo Bozzo, Simona Candiani and Michael Schubert

    33. Design of synthetic retinoids
    34. David R. Chisholm and Andrew Whiting

    35. Application of human organotypic skin raft cultures for analysis of retinoid metabolism, retinoic acid signaling, and screening of bioactive rexinoids
    36. Alla V. Klyuyeva, Kelli R. Goggans, Natalia Y. Kedishvili and Olga V. Belyaeva

    37. Tissue localization of retinoic acid receptor (RAR) active drugs
    38. Azita Kouchmeshky, Timothy Goodman, Andy Whiting and Peter McCaffery

    39. The development of methodologies for high-throughput retinoic acid binding assays in drug discovery and beyond
    40. Charles W.E. Tomlinson and Andrew Whiting

    41. Using the human CYP26A1 gene promoter as a suitable tool for the determination of RAR-mediated retinoid activity

Reza Zolfaghari, Floyd J. Mattie, Cheng-Hsin Wei, David R. Chisholm, Andrew Whiting and A. Catharine Ross


Retinoid Signaling Pathways, Volume 637, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Sections in this release include The chemistry and biochemistry of Vitamin A and its natural derivative, Biosynthesis of retinoic acids, Biodegration of retinoic acids mediated by retinoid binding proteins, Retinoic acid homeostasis, Cryo Electron Microscopy to study retinol update via the STRA6 receptor, Immuno-detection of retinoic acid synthesis enzymes in the brain, classical pathway of gene regulation by retinoids, Protein-protein interactions in the regulation of retinoid acid receptors activity, and much more.

Key Features

  • Provides the authority and expertise of leading contributors from an international board of authors
  • Presents the latest release in the Methods in Enzymology series
  • Includes the latest information on retinoid signaling pathways


Biochemists, biophysicists, molecular biologists, analytical chemists, and physiologists


No. of pages:
© Academic Press 2020
29th April 2020
Academic Press
Hardcover ISBN:
eBook ISBN:

Ratings and Reviews

About the Serial Volume Editor

Ehmke Pohl

Ehmke Pohl is at Durham University, Durham, UK

Affiliations and Expertise

Durham University, Durham, UK