Retinoid Signaling Pathways

Retinoid Signaling Pathways

1st Edition - April 29, 2020

Write a review

  • Editor: Ehmke Pohl
  • Hardcover ISBN: 9780128201442
  • eBook ISBN: 9780128201473

Purchase options

Purchase options
DRM-free (PDF, EPub, Mobi)
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order


Retinoid Signaling Pathways, Volume 637, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Sections in this release include The chemistry and biochemistry of Vitamin A and its natural derivative, Biosynthesis of retinoic acids, Biodegration of retinoic acids mediated by retinoid binding proteins, Retinoic acid homeostasis, Cryo Electron Microscopy to study retinol update via the STRA6 receptor, Immuno-detection of retinoic acid synthesis enzymes in the brain, classical pathway of gene regulation by retinoids, Protein-protein interactions in the regulation of retinoid acid receptors activity, and much more.

Key Features

  • Provides the authority and expertise of leading contributors from an international board of authors
  • Presents the latest release in the Methods in Enzymology series
  • Includes the latest information on retinoid signaling pathways


Biochemists, biophysicists, molecular biologists, analytical chemists, and physiologists

Table of Contents

      1. Vitamin A and its natural derivatives
      2. Chris P.F. Redfern

      3. Post-natal all-trans-retinoic acid biosynthesis
      4. Joseph L. Napoli

      5. Retinoid metabolism and functions mediated by retinoid binding-proteins
      6. Joseph L. Napoli and Hong Sik Yoo

      7. Generation and isolation of recombinant retinoid oxidoreductase complex
      8. Mark K. Adams, Olga V. Belyaeva and Natalia Y. Kedishvili

      9. Sample preparation for structural and functional analyses of the STRA6 receptor for retinol-binding protein
      10. Brianna K. Costabile, Youn-Kyung Kim, Yunting Chen, Oliver B. Clarke, Loredana Quadro and Filippo Mancia

      11. Use of fixatives for immunohistochemistry and their application for detection of retinoic acid synthesizing enzymes in the central nervous system
      12. Azita Kouchmeshky and Peter McCaffery

      13. Classical pathways of gene regulation by retinoids
      14. Ehmke Pohl and Charles W.E. Tomlinson

      15. Protein-protein interactions in the regulation of RAR–RXR heterodimers transcriptional activity
      16. Albane le Maire, Pierre Germain and William Bourguet

      17. Natural ligands of RXR receptors
      18. Patricia García, Paula Lorenzo and Angel R. de Lera

      19. DNA recognition by retinoic acid nuclear receptors
      20. Carole Peluso-Iltis, Judit Osz and Natacha Rochel

      21. Noncanonical retinoic acid signaling
      22. Jennifer Nhieu, Yu-Lung Lin and Li-Na Wei

      23. Retinoic acid and microRNA
      24. Lijun Wang, Atharva Piyush Rohatgi and Yu-Jui Yvonne Wan

      25. Analysis of vitamin A and retinoids in biological matrices
      26. Lindsay C. Czuba, Guo Zhong, King Yabut and Nina Isoherranen

      27. Effects of vitamin A and retinoic acid on mouse embryonic stem cells and their differentiating progeny
      28. Mary Ann Asson-Batres and Christopher W. Norwood

      29. Identifying vitamin A signaling by visualizing gene and protein activity, and by biochemical isolation of vitamin A metabolites
      30. Stephen R. Shannon, Jianshi Yu, Amy E. Defnet, Danika Bongfeldt, Alexander R. Moise, Maureen A. Kane and Paul A. Trainor

      31. Whole mount in situ hybridization and immunohistochemistry for studying retinoic acid signaling in developing amphioxus
      32. Matteo Bozzo, Simona Candiani and Michael Schubert

      33. Design of synthetic retinoids
      34. David R. Chisholm and Andrew Whiting

      35. Application of human organotypic skin raft cultures for analysis of retinoid metabolism, retinoic acid signaling, and screening of bioactive rexinoids
      36. Alla V. Klyuyeva, Kelli R. Goggans, Natalia Y. Kedishvili and Olga V. Belyaeva

      37. Tissue localization of retinoic acid receptor (RAR) active drugs
      38. Azita Kouchmeshky, Timothy Goodman, Andy Whiting and Peter McCaffery

      39. The development of methodologies for high-throughput retinoic acid binding assays in drug discovery and beyond
      40. Charles W.E. Tomlinson and Andrew Whiting

      41. Using the human CYP26A1 gene promoter as a suitable tool for the determination of RAR-mediated retinoid activity

    Reza Zolfaghari, Floyd J. Mattie, Cheng-Hsin Wei, David R. Chisholm, Andrew Whiting and A. Catharine Ross

Product details

  • No. of pages: 610
  • Language: English
  • Copyright: © Academic Press 2020
  • Published: April 29, 2020
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128201442
  • eBook ISBN: 9780128201473

About the Serial Volume Editor

Ehmke Pohl

Ehmke Pohl is at Durham University, Durham, UK

Affiliations and Expertise

Durham University, Durham, UK

Ratings and Reviews

Write a review

There are currently no reviews for "Retinoid Signaling Pathways"