- eBook ISBN 9780123914132
- Print ISBN 9780124159617
The media, scientific researchers, and the Diagnostic and Statistical Manual all refer to "autism" as if it were a single disorder or a single disorder over a spectrum. However, autism is unlike any single disorder in a variety of ways. No single brain deficit is found to cause it, no single drug is found to affect it, and no single cause or cure has been found despite tremendous research efforts to find same. Rethinking Autism reviews the scientific research on causes, symptomology, course, and treatment done to date…and draws the potentially shocking conclusion that "autism" does not exist as a single disorder. The conglomeration of symptoms exists, but like fever, those symptoms aren’t a disease in themselves, but rather a result of some other cause(s). Only by ceasing to think of autism as a single disorder can we ever advance research to more accurately parse why these symptoms occur and what the different and varied causes may be.
Developmental psychologists, child clinical psychologists, child psychiatrists, pediatric neurologists, and autism researchers.
Chapter 1. Autism Heterogeneity
Autism Heterogeneity is Extensive and Unexplained
Autism Heterogeneity has Blocked Medical Treatment Discovery
Diagnostic Criteria have not Constrained Autism Heterogeneity
Variation in Autism Diagnostic Features
Variation in Genetic Risk Factors for Autism
Variation in Environmental Risk Factors for Autism
Summary: Variation Exists in all Autism Domains
Autism Subgroups and Unifying Theories for Autism have Addressed Heterogeneity
Subgroups and Unifying Theories have not Explained the Variation in Autism
Has Autism been Reified?
Saving the Phenomena of Autism Variation
How Should We View the Variation in Autism?
Serious Concerns for Maintaining the Autism Diagnosis
Eight Claims Concerning Autism Variation and the Autism Diagnosis
Chapter 2. Autism Symptom Heterogeneity Exists in Family Members
Four Pairs of Siblings with Varying Autism Symptoms
Important Research Questions Raised by Variation in the Four Sibling Pairs
Infant Sibling, Twin, and Family Studies of Autism
Autism Symptoms in Identical and Fraternal Twins
Heterogeneity in the Broader Phenotype of Autism
Two Alternate Hypotheses about the Structure of the Broader Autism Phenotype
Conclusions: Recurrence Risk Rates and Family Phenotypes Reflect Aggregates
Chapter 3. The Social Brain is a Complex Super-Network
The Phrenology Problem
What Brain Circuits Support Social Behaviors?
Mechanisms of The “Dark Matter” of Human Social Cognition
Current Findings for “Social Brain” Deficits in Autism
The Range and Variation in Autism Social Brain Deficits Suggest that Multiple Disorders have been Aggregated in Autism
Conclusion: No Plausib
"A seminal book forcing a much-needed change in the way in which we think about autism. Impressively well-researched and well-argued. A 'must-read' for all autism researchers."
--Prof. Jill Boucher, City University, London, UK
"This book by Lynn Waterhouse will ruffle some feathers, with its bold conclusion that "there is clear detriment to maintaining the diagnostic category of autism spectrum disorder." However, the evidence she presents is compelling. In every domain she investigates - symptoms, neurobiology, etiology, correlates – she finds that there is considerable heterogeneity in autism. As well as striking differences among children with an ASD diagnosis, there is also a lack of specificity in symptoms and causes. For instance, genetic variants and environmental risks that are associated with increased risk of autism are also associated with other neurodevelopmental disorders.
Waterhouse is not denying that there are children with severe developmental difficulties involving social interaction, communication and stereotyped behaviours. Rather, she is questioning whether their needs are best served by grouping them all together under a single umbrella label.
Her view is that research efforts directed at finding a unifying theory of autism are misguided, and that we should be focusing on symptoms rather than an abstract diagnostic category that can obfuscate rather than clarify our understanding."
--Prof. Dorothy Bishop, University of Oxford, UK
"The book is an argument, not an opinion piece or political manifesto. It presents a pile of research findings, and makes a case for what they tell us…I’m grateful for Lynn Waterhouse’s book and fervently hope it will help knock autism research out of a rut (not to mention help improve everyday thinking about autism)… Rethinking Autism moves the conversation forward and I hope it will change our th