Key Features

  • Features international experts who discuss the most recent findings on symptomatic relief for your patients in a comprehensive section on current drug choices.
  • Covers co-morbidities and special populations so you can properly treat everyone from children to pregnant women to patients with other neurological disorders.
  • Emphasizes clinical material so you can apply the material to those secondary causes of restless legs syndrome such as anemia and rheumatoid arthritis.
  • Surveys the emerging understandings of the biology of the disorder to present you with a comprehensive understanding of restless legs syndrome.

Table of Contents

I. Introduction

1. General Introduction: Restless Legs Syndrome as a Neurological Conundrum, Werner Poewe

2. Introduction: The Patient’s Perspective, Robert Balkam

3. From 1685 to 2008: An Introduction to the Restless Legs Syndrome, Allison Chan and Christian Guilleminault

4. Introduction: Restless Legs Syndrome as a Movement Disorder, Stanley Fahn

5 Restless Legs Syndrome and Nocturnal Myoclonus (Periodic Limb Movements during Sleep): An Historical Review, Elio Lugaresi and Federica Provini

6 Introduction: Clinical Science of Restless Legs Syndrome, Sudhansu Chokroverty

II. Basic Science of Restless Legs Syndrome

A. Epidemiology and Genetics

7 The Epidemiology of Restless Legs Syndrome, Klaus Berger and Tobias Kurth

8 Genetics of Restless Legs Syndrome, Lan Xiong, Gustavo Turecki, Anastasia Levchenko, Claudia Gaspar, Wayne A. Hening, Jacques Montplaisir, Guy A. Rouleau

B. Pathophysiology

9 The Iron Metabolic System, Stacey L. Clardy, James R. Connor, and John Beard

10 Iron Dysregulation in Restless Legs Syndrome, Christopher J. Earley

11 The Brain’s Dopamine Systems and their Relevance to Restless Legs Syndrome, A. A. Freeman and D. B. Rye

12 Neuroimaging in Restless Legs Syndrome, Claudia Trenkwalder and Christopher J. Earley

13 Circadian Rhythm of Restless Legs Syndrome, Diego Garcia-Borreguero and Wayne A. Hening

14 Spinal Cord, Dopamine, Opiates and Restless Legs Syndrome, W. Paulus and E.D. Schomburg

III. Clinical Science of RLS

A. Diagnosis

15 Diagnosis of Restless Legs Syndrome, Richard P. Allen

16 Differential Diagnosis of Restless Legs Syndrome, Sudhansu Chokroverty

17 Periodic Limb Movements in Sleep (PLMS), Federica Provini, Roberto Vetrugno, Pasquale Montagna, and Raffaele Ferri

18 Sleep Laboratory Diagnosis of Restless Legs Syndrome,


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