Resident Stem Cells and Regenerative Therapy

1st Edition

Editors: Regina Coeli dos Santos Goldenberg Antonio Carlos Campos de Carvalho
Hardcover ISBN: 9780124160125
eBook ISBN: 9780123914415
Imprint: Academic Press
Published Date: 26th September 2012
Page Count: 304
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In the last 3 decades, stem cells have greatly impacted the scientific and lay communities, providing huge advances in the treatment of devastating human diseases, including myocardial infarction, diabetes, muscular dystrophy, cystic fibrosis, cirrhosis, and osteoporosis. Alongside debates of induced pluripotent stem cells and embryonic stem cells has been the discovery of adult stem cells in many different tissues. While these organ resident or progenitor stem cells offer prospects to contribute to tissue regeneration, they also present challenges because of the complexity of organ structures.

This book will present the main findings to date and the important factors to be considered when considering resident stem cells in regenerative therapies. Chapters on cardiac, brain, neural, liver, kidney, skeletal muscle, bone, pancreatic, skin, and lung resident stem cells will assist in defining the level of success that has been achieved and the direction for the road ahead. With contributions from leading laboratories, open questions related to resident stem cells and regenerative therapies will also be presented for debate.

Key Features

  • Highlights basic research in tissue specific stem cells, experiments with animal models and clinical trials that are transforming the field of regeneration
  • Provides a clear understanding of endogenous stem cells, their role in current regenerative therapies, and prospects for future research
  • Reports on the main-stream clinical approaches and in vivo experiments published in primary literature to help categorizes the advances in various aspects of regenerative therapy and illustrate opportunities for clinical applications


Advanced researchers and students in stem cell biology, regenerative medicine, bioengineering, tissue engineering, molecular biology, evolutionary and developmental biology

Table of Contents



List of Contributors

Chapter 1. Resident Stem Cells in Kidney Tissue

Introductory Remarks

Brief Description of the Structural Organization of the Mammalian Adult Kidney

Stem Cells in Kidney Organogenesis

Kidney Stem/Progenitor Cells: Niches and Isolation

The Role of Stem/Progenitor Cells in Kidney Regeneration

Role of Kidney Resident Stem/Progenitor Cells in the Establishment and Progression of Renal Disorders


Tubular Lesions

Progenitor/Resident Stem Cells and Renal Cancer

Stem/Progenitor Cells in Kidney: Features for Therapeutic Use after the Few Trials with Bone Marrow Cells?


Chapter 2. Pancreatic Stem Cells


Embryogenesis and Organogenesis


Chapter 3. Tissue Engineering and the Role of Biomaterial Scaffolds: The Evolution of Cardiac Tissue Engineering

Introduction to Tissue Engineering

Role of Biomaterials in Tissue Engineering

Clinical Translation and Commercialization

Future of Tissue Engineering

Cardiac Tissue Engineering

Future of Cardiac Tissue Engineering


Chapter 4. Resident Neural Stem Cells

Neurogenesis in the Adult Brain

Neurogenesis during Development

Neural Stem Cells

The Subventricular Zone

Subgranular Zone

Neural Stem Cell Markers

Neurogenesis’s Regulators

Cell Therapy


Chapter 5. Resident Stem Cell in Skin


Interfollicular Epidermis

Hair Follicle and Associated Structures



Cell Therapies and Clinical Application of Skin Stem Cells


Chapter 6. Lung Resident Stem Cells

Lung Structure

Hierarchy of Lung Resident Stem Cells

Resident Ep


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© Academic Press 2013
Academic Press
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About the Editor

Regina Coeli dos Santos Goldenberg

Antonio Carlos Campos de Carvalho