Resident Stem Cells and Regenerative Therapy

Resident Stem Cells and Regenerative Therapy

1st Edition - September 26, 2012

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  • Editors: Regina Coeli dos Santos Goldenberg, Antonio Carlos Campos de Carvalho
  • Hardcover ISBN: 9780124160125
  • eBook ISBN: 9780123914415

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In the last 3 decades, stem cells have greatly impacted the scientific and lay communities, providing huge advances in the treatment of devastating human diseases, including myocardial infarction, diabetes, muscular dystrophy, cystic fibrosis, cirrhosis, and osteoporosis. Alongside debates of induced pluripotent stem cells and embryonic stem cells has been the discovery of adult stem cells in many different tissues. While these organ resident or progenitor stem cells offer prospects to contribute to tissue regeneration, they also present challenges because of the complexity of organ structures. This book will present the main findings to date and the important factors to be considered when considering resident stem cells in regenerative therapies. Chapters on cardiac, brain, neural, liver, kidney, skeletal muscle, bone, pancreatic, skin, and lung resident stem cells will assist in defining the level of success that has been achieved and the direction for the road ahead. With contributions from leading laboratories, open questions related to resident stem cells and regenerative therapies will also be presented for debate.

Key Features

  • Highlights basic research in tissue specific stem cells, experiments with animal models and clinical trials that are transforming the field of regeneration
  • Provides a clear understanding of endogenous stem cells, their role in current regenerative therapies, and prospects for future research
  • Reports on the main-stream clinical approaches and in vivo experiments published in primary literature to help categorizes the advances in various aspects of regenerative therapy and illustrate opportunities for clinical applications


Advanced researchers and students in stem cell biology, regenerative medicine, bioengineering, tissue engineering, molecular biology, evolutionary and developmental biology

Table of Contents

  • Dedication


    List of Contributors

    Chapter 1. Resident Stem Cells in Kidney Tissue

    Introductory Remarks

    Brief Description of the Structural Organization of the Mammalian Adult Kidney

    Stem Cells in Kidney Organogenesis

    Kidney Stem/Progenitor Cells: Niches and Isolation

    The Role of Stem/Progenitor Cells in Kidney Regeneration

    Role of Kidney Resident Stem/Progenitor Cells in the Establishment and Progression of Renal Disorders


    Tubular Lesions

    Progenitor/Resident Stem Cells and Renal Cancer

    Stem/Progenitor Cells in Kidney: Features for Therapeutic Use after the Few Trials with Bone Marrow Cells?


    Chapter 2. Pancreatic Stem Cells


    Embryogenesis and Organogenesis


    Chapter 3. Tissue Engineering and the Role of Biomaterial Scaffolds: The Evolution of Cardiac Tissue Engineering

    Introduction to Tissue Engineering

    Role of Biomaterials in Tissue Engineering

    Clinical Translation and Commercialization

    Future of Tissue Engineering

    Cardiac Tissue Engineering

    Future of Cardiac Tissue Engineering


    Chapter 4. Resident Neural Stem Cells

    Neurogenesis in the Adult Brain

    Neurogenesis during Development

    Neural Stem Cells

    The Subventricular Zone

    Subgranular Zone

    Neural Stem Cell Markers

    Neurogenesis’s Regulators

    Cell Therapy


    Chapter 5. Resident Stem Cell in Skin


    Interfollicular Epidermis

    Hair Follicle and Associated Structures



    Cell Therapies and Clinical Application of Skin Stem Cells


    Chapter 6. Lung Resident Stem Cells

    Lung Structure

    Hierarchy of Lung Resident Stem Cells

    Resident Epithelial Progenitor Cells

    Resident Endothelium Progenitor Cells

    Resident Mesenchymal Progenitor Cells

    Lung Resident Stem Cells in Respiratory Diseases

    Main Challenges for the Identification of Lung Resident Stem Cells


    Chapter 7. Skeletal Resident Stem Cells

    Bone Tissue

    Bone Marrow as a Source of Mesenchymal Stem Cells–Stem Cells for Bones

    Mesenchymal Cells in Orthopedic Bioengineering and Bone Repair

    Skeletal Stem Cells and the Vascular System

    Combined Action: Therapeutic Use of Mesenchymal Progenitors and Angiogenic Progenitors

    Cell Therapy in Pseudarthrosis

    Cell Therapy in Avascular Necrosis of the Femoral Head (Osteonecrosis)



    Chapter 8. Cardiac Stem Cells

    c-Kit Positive Cells

    Cardiosphere-Derived Cells

    Side Population

    Islet-1 Positive Cells

    Conclusions and Future Directions


    Chapter 9. The Neural Crest and the Stem Cells of Neural Crest


    The Neural Crest

    Neural Crest-Derived Stem Cells (NCSCs)

    Are NC Cells a Source of Mesenchymal Stem Cells (MSCs)?

    Concluding Remarks



    Chapter 10. Liver Resident Stem Cell


    Liver Development

    Liver Regeneration: The Hierarchy for Cell Response

    Stem/Progenitor Cells: The Second Front in Liver Regeneration

    Fetal Hepatic Stem Cell Niche

    Adult Liver Stem/Progenitor Cell Niche

    Liver Stem/Progenitors Cells and Cell Therapy


    Chapter 11. Telocytes and Stem Cells

    What Are Telocytes?

    What Defines Telocytes as a Unique, Distinct Cell Type?

    Comparison with Fibroblasts

    Where Are Telocytes Located?

    Telocyte Intercellular Relationships

    Phenotype “Portrait”

    The Tandem Telocytes & Stem Cells

    A Hope for Regenerative Medicine

    Future Research Directions


    Chapter 12. Pericytes as the Source of Mesenchymal Stem Cells


    Relationship between Pericytes and MSCs

    The Plasticity Issue

    Pericytes as Stem Cells in the Body




    Color Plates


Product details

  • No. of pages: 304
  • Language: English
  • Copyright: © Academic Press 2012
  • Published: September 26, 2012
  • Imprint: Academic Press
  • Hardcover ISBN: 9780124160125
  • eBook ISBN: 9780123914415

About the Editors

Regina Coeli dos Santos Goldenberg

Antonio Carlos Campos de Carvalho

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