Research Surgery and Care of the Research Animal

Methods of Animal Experimentation, Volume VII: Research Surgery and Care of the Research Animal, Part C is a collection of papers that deals with methods used in animal experiments concerning surgical approaches to certain organ systems such as the maxillofacial and skin systems. This collection deals with surgery involving the oral and maxillofacial, ophthalmic, skin systems, as well as research on canine immune systems and applications of microsurgery and laser surgery. One paper discusses orthognathic surgery including temporomandibular joint and dental implants. Another paper describes corneal procedures, lens extraction, and intraocular lenses. In discussing skin experimental surgery, the author explains procedures in flap anatomy, surgical healing, skin grafting, and burn treatment. The techniques in studying the immune systems of dogs include procedures dealing with peripheral blood, bone marrow, reactive cells, and tissues. Other authors explain the application of microsurgery to laboratory research including the equipment and techniques used, as well as the general principles of tissue transplantation into the animal's central nervous system. Another author discusses the use of lasers and special considerations such as laser restrictions and instrumentation. This book will be appreciated by laboratory assistants and scientists dealing with test animals, by veterinarians, and by researchers designing animal and medical experiments.

Foreword

Preface

Chapter 1 Animal Research Models in Oral and Maxillofacial Surgery

I. Introduction

II. Orthognathic Surgery

III. Experimental Fractures

IV. Temporomandibular Joint

V. Bone Grafting

VI. Dental Implants

VII. Osteomyelitis

VIII. Tooth Transplantation

IX. Alveolar Cleft Grafts

X. Summary

References

Chapter 2 Ophthalmic Surgery on Laboratory Animals

I. Introduction

II. Corneal Procedures

III. Lens Extraction and Intraocular Lenses

IV. Intraocular Injections

V. Vitrectomy

VI. Use of Surgical Models in Glaucoma Research

VII. Lasers in Ophthalmic Surgery

VIII. Adjunctive Medications and Devices in Intraocular Surgery

References

Chapter 3 Experimental Skin Surgery

I. Introduction

II. Flap Anatomy and Physiology

III. Microsurgery

IV. Wound Healing as It Relates to Skin Surgery

V. Skin Grafting

VI. Burns

VII. Summary

References

Chapter 4 Experimental Techniques Used to Study the Immune System of Dogs and Other Large Animals

I. Introduction

II. Immunologically Reactive Tissue

III. Immunocompetence and Immunosuppression

IV. Experimental Techniques for Peripheral Blood

V. Experimental Techniques for Bone Marrow

VI. Procedures Involving Other Immunologically Reactive Cells and Tissues

VII. Procedures for Establishing and Using Experimental Immune Models

References

Chapter 5 The Application of Microsurgery to Laboratory Research

I. Introduction and History

II. Equipment

III. Techniques

IV. Summary and Future Laboratory Microsurgery

References

Chapter 6 Neurotransplantation

I. History and Rationale

II. General Principles of Transplantation into the Nervous System

III. Model Systems for Transplantation

IV. Immunology of CNS Transplants

V. Vascularity of Neural Transplants

VI. Conclusions

References

Chapter 7 Experimental Surgery Using Lasers

I. Introduction

II. Laser Physics

III. Special Considerations

IV. Laser-Tissue Interactions

V. Animal Models for Surgical Applications of Lasers

References

Index