Research on Steroids

Research on Steroids

Proceedings of the Fourth Meeting of the International Study Group for Steroid Hormones

1st Edition - January 1, 1971

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  • Editors: M. Finkelstein, A. Klopper, C. Conti
  • eBook ISBN: 9781483154039

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Research on Steroids contains the proceedings of the Fourth Meeting of the International Study Group for Steroid Hormones. The papers explore the production, chemical characterization, and metabolism of steroid hormones and their interactions with proteins. Topics range from the action of estradiol in vitro to water-soluble metabolites of estrogens, transport of steroids by proteins, and immunological aspects of steroid hormones. The binding of steroids by tissue proteins is also discussed, along with the use of specific plasma proteins for the determination of steroids. This volume is comprised of 38 chapters and begins with an overview of the general aspects of steroid-protein interaction, followed by a discussion on quantitative studies of steroid binding proteins; aromatization of testosterone by human placenta enzymes; relationship between plasma binding and 5α-reduction of testosterone; cortisol-binding capacity of plasma transcortin in subjects treated with various anabolic steroids; and plasma testosterone binding capacity and estrogen excretion in normal and pathological pregnancies. Subsequent chapters deal with the interaction between estrogenic and carcinogenic substances in the rat mammary gland; influence of steroid production on serum albumin in Cushing's syndrome; and nuclear estradiol binding proteins in the uterus. This book will be of interest to biochemists, biologists, and physiologists.

Table of Contents

  • Section I General Aspects of Steroid-Protein Interaction


    General Aspects of Steroid-Protein Interaction


    The "Biological Exchange Constant" of Estradiol-17ß between Plasma and Uterus in Adult and Immature Rats

    Quantitative Studies of Steroid Binding Proteins

    Action of Oestradiol In Vitro: Increase in Ribonucleic Acid Biosynthesis in Uterine Nuclei

    Aromatization of Testosterone by Human Placenta Enzymes: Role of a Protein Fraction obtained from pregnant Female Serum which binds Testosterone (T) and Oestradiol-17ß(E2)

    Stability and Nature of In Vivo Binding between Testosterone, its Metabolites and Organ Proteins in Rats

    Water Soluble Metabolites of Oestrogens: A Model of Covalent Steroid Protein Binding

    Section 2 Transport of Steroids by Proteins


    Transport of Steroids by Proteins


    The Binding of Progesterone by the α1-Acid Glycoprotein

    Interaction of Steroids with Human Red Blood Cells

    Relationship between Plasma Binding and 5α-Reduction of Testosterone

    Comparative Studies on the Binding of Testosterone and 17ß-Oestradiol by Serum Proteins in Normals and in Patients with Liver Cirrhosis

    Cortisol-Binding Capacity of Plasma Transcortin in Subjects Treated with Various Anatolic Steroids

    Section 3


    A 4S Oestradiol-Binding Protein in Uteri from Mature Rats that is Controlled by Endogenous Hormones

    Plasma Testosterone Binding Capacity and Oestrogen Excretion in Normal and Pathological Pregnancies

    Interaction between Oestrogenic and Carcinogenic Substances in the Rat Mammary Gland

    Metabolization and Binding of Oestradiol-17ß by Rat Ventral Prostate In Vitro

    Interaction of Diethylstilbestrol with Uterine Receptor Sites

    Biological Inactivation of Progesterone by Interaction with Corticosteroid-Binding Globulin and with Albumin

    Effects of Clomiphene Citrate on Binding Affinity of Testosterone, Oestradiol and Cortisol in Serum of Normal Adult Men

    Influence of Steroid Production on Serum Albumin in Cushing's Syndrome

    Section 4 Immunological Aspects of Steroid Hormones


    Studies with Antibodies to Steroids


    Neutralization of Exogenous Estradiol Activity following Active Immunization Procedures

    Antibodies to Oestrogens

    Solid Phase Radioimmunoassay of Estradiol-17ß and Estrone

    Section 5 Binding of Steroids by Tissue Proteins


    Binding of Steroids by Tissue Proteins. Steroid hormone, "Receptors"


    Cortisol-Binding Protein from various Tissues

    Progesterone-Binding by the Soluble Fraction of Corpus Luteum from the Pregnant Cow

    Effect of I2 and Sulphydryl Reagents on Binding Activity of Estrogen Receptors

    Nuclear Oestradiol Binding Proteins in the Uterus

    Oestradiol-Binding and Protein Phosphorylation

    Partial Purification of an Estrophilic Protein from Calf Uterus

    Section 6 Use of Specific Plasma Proteins for the Determination of Steroids


    Use of Specific Plasma Proteins for the Determination of Steroids


    Plasma Estrogen Assays Utilizing the Cytoplasmic Estrogen Binder of Rabbit Uterus

    Plasma Progesterone and 17α-hydroxyprogesterone Measured by a Competitive Protein Binding Technique and Related to the Oestrogen Excretion and LH Level around Ovulation in the Normal Menstrual Cycle

    ACTH-Induced Fall in Plasma Testosterone

    A Method for Estimation of Plasma Testosterone using a Technique Depending on Competitive Protein Binding

    Study of C19O2 Steroids in Human Plasma by Competitive Protein Binding

    Partial Purification and Preliminary Characterization of an Estrogen Binding Protein (Estrogen Receptor) from Calf Uterus Nuclear Fraction

    Author Index

Product details

  • No. of pages: 342
  • Language: English
  • Copyright: © Pergamon 1971
  • Published: January 1, 1971
  • Imprint: Pergamon
  • eBook ISBN: 9781483154039

About the Editors

M. Finkelstein

A. Klopper

C. Conti

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