Research and Clinical Applications of Targeting Gastric Neoplasms

Research and Clinical Applications of Targeting Gastric Neoplasms

1st Edition - July 17, 2021

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  • Editor: Brendan Jenkins
  • Paperback ISBN: 9780323855631
  • eBook ISBN: 9780323885546

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Description

Research and Clinical Applications of Targeting Gastric Neoplasms provides a comprehensive overview of gastrointestinal cancers, covering preclinical research and clinical findings related to risk factors, current treatment regimens (including immunotherapy), screening/detection methods, etiology of disease, precision medicine and future perspectives. Gastrointestinal cancers rank among the most lethal and common worldwide, and as such, there is intense research into their diverse causes and treatment options. This reference provides a consolidation of the research, making it a perfect resource for basic science and clinical researchers as well as oncologists who work in gastroenterology and GI tract cancer fields.

Key Features

  • Provides comprehensive coverage of preclinical research and the clinical aspects of gastric cancer
  • Presents future perspectives from leading researchers in the field who provide the potential for furthering research topics
  • Combines the expertise of researchers in GI tracts, cancer, immunity, immunology, infectious disease and microbiology for an interdisciplinary approach

Readership

Basic science and clinical researchers of the gastric system; as well as oncologists, in the gastroenterology and GI tract cancer fields. Gastroenterologists, Immunologists and Cancer Biologists

Table of Contents

  • 1. Stomach corpus stem cells in homeostasis, tissue repair, and cancer
    2. The role of inflammation in gastric tumorigenesis
    3. Unravelling the pro-tumorigenic role of innate immune pattern recognition receptors in the gastric compartment
    4. Helicobacter pylori-induced gastric carcinogenesis
    5. The role of Helicobacter pylori CagA oncoprotein in neoplastic transformation of gastric epithelial cells
    6. Epigenetic aberrations by Epstein–Barr virus infection to develop gastric cancer
    7. In vivo and in vitro models of gastric cancer
    8. Premalignant lesions of the stomach and management of early neoplastic lesions
    9. Updated perspective and directions on hereditary diffuse gastric cancer
    10. Systems biology and molecular characterization of subtypes to guide targeted therapies in gastric cancer
    11. Current state of chemotherapy and immunotherapy regimens in gastric cancer
    12. Case studies highlighting the multiple facets of gastric cancer: one diagnosis, multiple approaches1. Stomach corpus stem cells in homeostasis, tissue repair, and cancer
    2. The role of inflammation in gastric tumorigenesis
    3. Unravelling the pro-tumorigenic role of innate immune pattern recognition receptors in the gastric compartment
    4. Helicobacter pylori-induced gastric carcinogenesis
    5. The role of Helicobacter pylori CagA oncoprotein in neoplastic transformation of gastric epithelial cells
    6. Epigenetic aberrations by Epstein–Barr virus infection to develop gastric cancer
    7. In vivo and in vitro models of gastric cancer
    8. Premalignant lesions of the stomach and management of early neoplastic lesions
    9. Updated perspective and directions on hereditary diffuse gastric cancer
    10. Systems biology and molecular characterization of subtypes to guide targeted therapies in gastric cancer
    11. Current state of chemotherapy and immunotherapy regimens in gastric cancer
    12. Case studies highlighting the multiple facets of gastric cancer: one diagnosis, multiple approaches

Product details

  • No. of pages: 370
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: July 17, 2021
  • Imprint: Academic Press
  • Paperback ISBN: 9780323855631
  • eBook ISBN: 9780323885546

About the Editor

Brendan Jenkins

Prof. Brendan Jenkins is an internationally renowned researcher who studies inflammation-associated cancers of the stomach, pancreas and lung, the latter of which is also linked to chronic obstructive pulmonary disease (COPD). His vision is to identify and develop new diagnostics and immunotherapies for these diseases. Prof. Jenkins is head of the Cancer and Immune Signaling Laboratory of the Hudson Institute of Medical Research in Victoria, Australia, and he is also a Professor in the Faculty of Medicine, Nursing and Health Sciences of Monash University. He has received over 20 national and international awards for his research and is a Senior Research Fellow of the Australian National Health and Medical Research Council (2014-2023); prior to that he held a prestigious Viertel Senior Medical Research Fellowship (2009-2013). He received his PhD in Medicine from the University of Adelaide, South Australia in 1998.

Affiliations and Expertise

Head, Cancer and Immune Signaling Laboratory, Hudson Institute of Medical Research; Professor, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia

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