Research Advances in Rabies

Research Advances in Rabies

1st Edition - May 27, 2011

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  • Editor: Alan Jackson
  • eBook ISBN: 9780123870414
  • Hardcover ISBN: 9780123870407

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Volume 79 of Advances in Virus Research focuses on developments surrounding rabies, an ancient disease that remains a prominent public health problem for humans. This volume highlights important research advances extending from our understanding of how the rabies virus replicates and assembles to how the disease can be prevented and treated in humans and how rabies can be controlled in wildlife hosts. Experts in the field provide insightful and up-to-date chapters that summarize our current state of knowledge in diverse aspects of this very interesting and important viral disease.

Key Features

  • Contributions from leading authorities and industry experts
  • Informs and updates on all the latest developments in the field


Virologists, microbiologists and infectious diseases specialists

Table of Contents

  • Preface

    Rabies Virus Transcription and Replication

    I. Introduction

    II. Molecular Aspects of Viral Transcription and Replication

    III. Structural Aspect of RABV Transcription and Replication; Proteins Involved in Transcription and Replication

    IV. Cellular Aspect of Rabies Transcription and Replication: IBs Formed in Infected Cells Are the Sites of Viral RNA Synthesis

    V. Concluding Remarks


    Rabies Virus Assembly and Budding

    I. Introduction

    II. Rabies Virus M Protein

    III. The Central Role of M and Supporting Role of G in RABV Budding

    IV. Features of M Protein Important for Budding

    V. Viral L-Domain/Host Interactions

    VI. Ubiquitination and RABV Budding

    VII. Summary


    Evasive Strategies in Rabies Virus Infection

    I. Introduction

    II. Evasion from host immune responses

    III. Preservation of neuron and neuronal network integrity

    IV. Conclusions on RABV Evasive Strategies

    Rabies Virus Clearance from the Central Nervous System

    I. Introduction

    II. Rabies Virus

    III. Animal Reservoirs of the Rabies Virus and the Threat of Human Rabies

    IV. Human Rabies

    V. The Current Rabies Postexposure Treatment Paradigm

    VI. Obstacles in Clearing Wild-type Rabies Virus from the CNS

    VII. Prospects for Human Rabies Immunotherapy Through Virus Clearance From the CNS


    Role of Chemokines in Rabies Pathogenesis and Protection

    I. Introduction

    II. Chemokines

    III. The Role of Chemokines in the CNS When Infected by Viruses

    IV. Induction of Chemokine Expression in RABV Infections

    V. Overexpression of Chemokines Can Benefit the Host If the Expression Is Transient While It Harms the Host If the Expression Is Persistent During RABV Infections

    VI. Chemokines Expression Correlates with the Activation of Dendritic Cells and Enhancement of Adaptive Immunity

    VII. Recombinant RABV Expressing Chemokines/Cytokines Can Be Used Effectively to Prevent the Development of Rabies

    VIII. Summary


    Interferon in Rabies Virus Infection

    I. Introduction

    II. Rabies and Interferon

    III. Conclusions and Future Outlook


    The Role of Toll-Like Receptors in the Induction of Immune Responses During Rabies Virus Infection

    I. Toll-Like Receptors

    II. Rabies in MyD88-Deficient Mice

    III. The Host Response to Rabies Infection Involves TLR7

    IV. The Contribution of TLR7 Signaling to the Control of Rabies Virus Spread to the CNS and Clearance from CNS Tissues

    V. TLR7 and the Diverse Pathogenicities of Rabies Virus Variants

    VI. Conclusions and Relevance to Therapeutic Immunization


    Role of Oxidative Stress in Rabies Virus Infection

    I. Introduction

    II. Degeneration of Neuronal Processes in Experimental Rabies

    III. Cultured Dorsal Root Ganglion Neurons for Studying Neuronal Process Degeneration

    IV. Oxidative Stress

    V. Oxidative Stress in Rabies Virus Infection

    VI. Conclusions


    Rabies Virus as a Research Tool and Viral Vaccine Vector

    I. Rabies Virus as a Research Tool

    II. The Need for Novel Vaccines for RABV

    III. Modified Replication-Competent RABV as Rabies Vaccines for Wildlife

    IV. RABV-Based Vectors as Vaccines Against Other Infectious Diseases

    V. Safety: Generating Safer RABV Vaccines and Vectors for Use in Humans

    VI. Replication-Deficient or Single-Cycle RABV

    VII. Potential Novel Human Rabies Vaccines Based on Replication-Deficient RABV

    VIII. Replication-Deficient/Single-Cycle RABV as Vaccine Vector

    IX. Killed RABV–RABV Proteins as Carriers of Foreign Antigens

    Rabies Virus as a Transneuronal Tracer of Neuronal Connections

    I. Introduction

    II. Differences in Properties of Alpha-Herpesviruses and Rabies Virus as Transneuronal Tracers

    III. Rabies Virus

    IV. Perspectives


    Molecular Phylogenetics of the Lyssaviruses—Insights from a Coalescent Approach

    I. Introduction

    II. Lyssavirus Phylogeny

    III. Lyssavirus Phylogeography

    IV. Lyssavirus Adaptation

    V. Concluding Remarks

    Bats and Lyssaviruses

    I. Introduction

    II. Bat Lyssaviruses: Eurasia and Australasia

    III. Bat Lyssaviruses: Africa

    IV. Bat Rabies and the Americas

    V. Discussion


    Postexposure Prophylaxis for Rabies in Resource-Limited/Poor Countries

    I. Introduction

    II. Local Wound Care

    III. Evaluation of Risk of Rabies Exposure

    IV. Postexposure Prophylaxis of Previously Unvaccinated Patients

    V. Postexposure Prophylaxis in Previously Vaccinated Patients

    VI. Postexposure Prophylaxis Failures

    Neuroimaging in Rabies

    I. Introduction

    II. Neuroimaging Techniques

    III. Neuroimaging in Rabies

    IV. Newer Neuroimaging Techniques in Rabies

    V. Conclusions


    Rabies Virus Infection and MicroRNAs

    I. Introduction

    II. MicroRNAs

    III. miRNAs and Viruses

    IV. Inhibition of Rabies Viral Replication by siRNA/amiRNA

    V. Conclusions

    Design of Future Rabies Biologics and Antiviral Drugs

    I. Introduction

    II. Vaccines

    III. Antibodies

    IV. Antiviral Drugs

    V. Conclusions

    Therapy of Human Rabies

    I. Introduction

    II. Prevention of Rabies

    III. Therapy of Rabies

    IV. New Approaches

    V. Conclusions

    Mathematical Models for Rabies

    I. Introduction

    II. The Development of the Mathematical Approach to Rabies Dynamics

    III. Modeling Approaches Using Reaction Diffusion Methods

    IV. Methods for Incorporating Landscape Heterogeneities

    V. Stochastic Models

    VI. Incorporating Stochasticity and Spatial Heterogeneity

    VII. Optimal Control

    VIII. Conclusions


    Evolution of Wildlife Rabies Control Tactics

    I. Introduction

    II. Historical and Contemporary Wildlife Rabies Control Tactics

    III. Advances in Rabies Vaccine-Bait Delivery Systems for Wildlife

    IV. Advances in Wildlife Rabies Vaccines

    V. Advances in the Assessment of Wildlife Vaccination Systems

    VI. Advances in Contingency and Management Planning for Wildlife Rabies Control

    VII. Advances in Technologies for Studying the Ecology of the Rabies Virus and Wildlife Rabies Vector Species

    VIII. Summary

    Understanding Effects of Barriers on the Spread and Control of Rabies

    I. The Concept and Mechanisms of Barriers

    II. Assessing Barrier Effects

    III. Assessing Interaction of Vaccination Barriers and Habitat Patterns

    IV. Discussion


    Rabies Research in Resource—Poor Countries

Product details

  • No. of pages: 486
  • Language: English
  • Copyright: © Academic Press 2011
  • Published: May 27, 2011
  • Imprint: Academic Press
  • eBook ISBN: 9780123870414
  • Hardcover ISBN: 9780123870407

About the Serial Volume Editor

Alan Jackson

Dr. Alan Jackson is Professor of Medicine (Neurology) at University of Manitoba in Winnipeg, Manitoba, Canada. He graduated from Queen’s University with BA and MD degrees. He completed an internship in internal medicine at University of Southern California, residencies in internal medicine at Queen’s University and in neurology at the University of Western Ontario, and a fellowship in neurovirology at The Johns Hopkins University with Drs. Richard Johnson and Diane Griffin. Dr. Jackson was active in basic rabies research for over 30 years.

Affiliations and Expertise

Professor of Medicine (Neurology), University of Manitoba, Winnipeg, Manitoba, Canada

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