Description

Volume 79 of Advances in Virus Research focuses on developments surrounding rabies, an ancient disease that remains a prominent public health problem for humans. This volume highlights important research advances extending from our understanding of how the rabies virus replicates and assembles to how the disease can be prevented and treated in humans and how rabies can be controlled in wildlife hosts. Experts in the field provide insightful and up-to-date chapters that summarize our current state of knowledge in diverse aspects of this very interesting and important viral disease.

Key Features

  • Contributions from leading authorities and industry experts
  • Informs and updates on all the latest developments in the field

Readership

Virologists, microbiologists and infectious diseases specialists

Table of Contents

Preface

Rabies Virus Transcription and Replication

I. Introduction

II. Molecular Aspects of Viral Transcription and Replication

III. Structural Aspect of RABV Transcription and Replication; Proteins Involved in Transcription and Replication

IV. Cellular Aspect of Rabies Transcription and Replication: IBs Formed in Infected Cells Are the Sites of Viral RNA Synthesis

V. Concluding Remarks

Acknowledgments

Rabies Virus Assembly and Budding

I. Introduction

II. Rabies Virus M Protein

III. The Central Role of M and Supporting Role of G in RABV Budding

IV. Features of M Protein Important for Budding

V. Viral L-Domain/Host Interactions

VI. Ubiquitination and RABV Budding

VII. Summary

Acknowledgments

Evasive Strategies in Rabies Virus Infection

I. Introduction

II. Evasion from host immune responses

III. Preservation of neuron and neuronal network integrity

IV. Conclusions on RABV Evasive Strategies

Rabies Virus Clearance from the Central Nervous System

I. Introduction

II. Rabies Virus

III. Animal Reservoirs of the Rabies Virus and the Threat of Human Rabies

IV. Human Rabies

V. The Current Rabies Postexposure Treatment Paradigm

VI. Obstacles in Clearing Wild-type Rabies Virus from the CNS

VII. Prospects for Human Rabies Immunotherapy Through Virus Clearance From the CNS

Acknowledgments

Role of Chemokines in Rabies Pathogenesis and Protection

I. Introduction

II. Chemokines

III. The Role of Chemokines in the CNS When Infected by Viruses

IV. Induction of Chemokine Expression in RABV Infections

V. Overexpression of Chemokines Can Benefit the Host If the Expression Is Transient While It Harms the Host If the Expression Is Persistent During RABV

Details

No. of pages:
486
Language:
English
Copyright:
© 2011
Published:
Imprint:
Academic Press
Electronic ISBN:
9780123870414
Print ISBN:
9780123870407

About the serial-volume-editor

Alan Jackson

Dr. Jackson is Professor of Medicine (Neurology) and of Medical Microbiology and also Head of the Section of Neurology at University of Manitoba in Winnipeg, Manitoba, Canada. He graduated from Queen’s University with BA and MD degrees. He completed an internship in internal medicine at University of Southern California, residencies in internal medicine at Queen’s University and in neurology at the University of Western Ontario, and a fellowship in neurovirology at The Johns Hopkins University with Drs. Richard Johnson and Diane Griffin. Dr. Jackson held a faculty position at Queen’s University from 1987 - 2007. He is on the Editorial Boards of the Journal of NeuroVirology and the Canadian Journal of Neurological Sciences. He is President of Rabies in the Americas, Inc. and is on the Board of Directors of the International Society for Neurovirology. Dr. Jackson is the principal investigator on research grants to study experimental aspects of rabies.

Reviews

"A mandatory purchase for all types of comprehensive libraries, both public and university, as well as for those interested in or doing research in the field of virology." --Military Medicine

"This serial...is well known to virologists. It is a valuable aid in maintaining an overview of various facets of the rapidly expanding fields of virology...Timely, informative, and useful to the student, teacher, and research scientist." --American Scientist