Research Advances in Rabies, Volume 79

1st Edition

Print ISBN: 9780123870407
eBook ISBN: 9780123870414
Imprint: Academic Press
Published Date: 27th May 2011
Page Count: 486
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Volume 79 of Advances in Virus Research focuses on developments surrounding rabies, an ancient disease that remains a prominent public health problem for humans. This volume highlights important research advances extending from our understanding of how the rabies virus replicates and assembles to how the disease can be prevented and treated in humans and how rabies can be controlled in wildlife hosts. Experts in the field provide insightful and up-to-date chapters that summarize our current state of knowledge in diverse aspects of this very interesting and important viral disease.

Key Features

  • Contributions from leading authorities and industry experts
  • Informs and updates on all the latest developments in the field


Virologists, microbiologists and infectious diseases specialists

Table of Contents


Rabies Virus Transcription and Replication

I. Introduction

II. Molecular Aspects of Viral Transcription and Replication

III. Structural Aspect of RABV Transcription and Replication; Proteins Involved in Transcription and Replication

IV. Cellular Aspect of Rabies Transcription and Replication: IBs Formed in Infected Cells Are the Sites of Viral RNA Synthesis

V. Concluding Remarks


Rabies Virus Assembly and Budding

I. Introduction

II. Rabies Virus M Protein

III. The Central Role of M and Supporting Role of G in RABV Budding

IV. Features of M Protein Important for Budding

V. Viral L-Domain/Host Interactions

VI. Ubiquitination and RABV Budding

VII. Summary


Evasive Strategies in Rabies Virus Infection

I. Introduction

II. Evasion from host immune responses

III. Preservation of neuron and neuronal network integrity

IV. Conclusions on RABV Evasive Strategies

Rabies Virus Clearance from the Central Nervous System

I. Introduction

II. Rabies Virus

III. Animal Reservoirs of the Rabies Virus and the Threat of Human Rabies

IV. Human Rabies

V. The Current Rabies Postexposure Treatment Paradigm

VI. Obstacles in Clearing Wild-type Rabies Virus from the CNS

VII. Prospects for Human Rabies Immunotherapy Through Virus Clearance From the CNS


Role of Chemokines in Rabies Pathogenesis and Protection

I. Introduction

II. Chemokines

III. The Role of Chemokines in the CNS When Infected by Viruses

IV. Induction of Chemokine Expression in RABV Infections

V. Overexpression of Chemokines Can Benefit the Host If the Expression Is Transient While It Harms the Host If the Expression Is Persistent During RABV


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"This well known to virologists. It is a valuable aid in maintaining an overview of various facets of the rapidly expanding fields of virology...Timely, informative, and useful to the student, teacher, and research scientist." --American Scientist