Reproductomics - 1st Edition - ISBN: 9780128125717

Reproductomics

1st Edition

The –Omics Revolution and its Impact on Human Reproductive Medicine

Editors: José A. Horcajadas Jaime Gosálvez
Paperback ISBN: 9780128125717
Imprint: Academic Press
Published Date: 1st May 2018
Page Count: 464
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Description

Reproductomics: The –Omics Revolution and its Impact on Human Reproductive Medicine shows how genomics and various omics technologies are already significantly aiding fertility specialists and clinicians in counseling couples towards pregnancy success, characterizing patients and informing embryo selection. Information derived from omics approaches and bioinformatics are coupled, offering an in-depth view of the human reproduction system. A diverse range of chapters from international experts demonstrate the complex relationship between genomics, epigenomics, transcriptomics, proteomics, and metabolomics and their role in human reproduction, identifying within these singular pathways specific genomic and molecular factors of translational impact.

With this book, editors Jaime Gosálvez and José Horcajadas have provided researchers and clinicians with a strong foundation for a new era of personalized reproductive medicine.

Key Features

  • Provides a thorough introduction to the omics revolution and its implications for reproductive medicine, clearly illustrating the complex relationship between genomic, epigenomic, transcriptomic, proteomic and metabolomic pathways
  • Demonstrates how genomics and other omics approaches are already aiding fertility specialists and clinical geneticists in counseling couples towards pregnancy success
  • Identifies specific genomic and molecular factors of translational impact that may assist researchers and clinicians in better understanding omics approaches to treating infertility and analyzing patient data
  • Features chapter contributions by leading international experts

Readership

Active researchers, clinicians, and students in the areas of human genetics, genomics, gynecology, obstetrics, andrology, embryology, endocrinology, and bioinformatics

Table of Contents

INTRODUCTION
1. Human Genome Projects: the starting point
2. Classic spermiogram: still informative?

GENOMICS
3. Genetics variations and human infertility
4. Preconceptional analysis of monogenic diseases
5. Genetic selection of the human embryos: from FISH to NGS, past and future
6. Non-invasive prenatal diagnosis
7. Genetic point mutations in male infertility
8. Telomere length and idiopathic infertility

FUNCTIONAL GENOMICS OR TRANSCRIPTOMICS
9. The molecular signature of the endometrial receptivity: research and clinical application
10. Gene expression of cumulus cells: an indirect diagnosis of oocyte quality
11. Variations in the gene expression of the sperm: clinical use
12. Transcriptomic of the embryo and embryo viability: the inner cell mass and the trophoblast
13. Altered gene expression profiles associated with infertility
14. Prostasomes and fertility
15. Small RNAs in human sperm

PROTEOMICS AND METABOLOMICS
16. Non-invasive methods of embryo selection
17. Proteomics and metabolomics studies and clinical outcomes

EPIGENOMICS
18. Epigenetics in spermatogenesis
19. Epigenetics, spermatogenesis and male infertility
20. Changes in DNA methylation related with male infertility
21. Epigenomics of the embryo: in vivo and in vitro evidences
22. Artificial Spermatoza

COMPUTATIONAL BIOLOGY
23. Computational approaches in Reproductomics

CONCLUSIONS
24. Year 2050: The “-Omics” technologies and Personalized Assisted Reproduction

Details

No. of pages:
464
Language:
English
Copyright:
© Academic Press 2018
Published:
Imprint:
Academic Press
Paperback ISBN:
9780128125717

About the Editor

José A. Horcajadas

Jose Horcajadas, PhD, is Associate Professor at the University Pablo de Olavide, Sevilla, Spain. Dr. Horcajadas is an expert in translational research with emphasis on human implantation. He has more than 50 publications in high-impact peer reviewed journals including The Journal of Endocrinology and Metabolism. For the past 3 years Dr. Horcajadas has been an active collaborator in the development of a three-dimensional endometrial culture system at The Jones Institute, which has resulted in several significant publications and presentations. Dr. Horcajadas has also presented at various national and international meetings.

Affiliations and Expertise

University Pablo de Olavide, Sevilla, Spain

Jaime Gosálvez

Professor Jaime Gosalvez is a permanent member of the Department of Genetics at the Universidad Autonoma of Madrid in Spain. He received his Ph.D. in Biology with specialization in Genetics in 1979. He teaches courses on Molecular Cytogenetics, Models and Evolutive Processes and Advanced Technologies for Biology. His research interests are in the areas of molecular cytogenetics with special emphasis on DNA structure and function. He is deeply involved in the analysis of different aspects of the DNA molecule in the sperm and their possible implications in male infertility, with special emphasis in human, other mammalian species and fish, as well as those clinical aspects of the male factor to achieve pregnancy. Dr. Gosálvez has published more than 250 original articles and 190 abstracts have been presented in different national and international meetings. He has published 15 book chapters in the area of cytogenetics and sperm quality assessment and has edited two books. He has been the Principal Investigator of more than 30 national and international competitive research applications, and he is co-author of two patents with world-wide protection.

Affiliations and Expertise

Department of Genetics, Universidad Autonoma of Madrid, Madrid, Spain