Reproductive and Developmental Toxicology - 2nd Edition - ISBN: 9780128042397

Reproductive and Developmental Toxicology

2nd Edition

Editors: Ramesh C. Gupta
Hardcover ISBN: 9780128042397
Imprint: Academic Press
Published Date: 21st April 2017
Page Count: 1458
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Reproductive and Developmental Toxicology, Second Edition, is a comprehensive and authoritative resource that provides the latest literature on this complex subject with a primary focus on three core components—parent, placenta, and fetus—and the continuous changes that occur in each. Enriched with relevant references describing every aspect of reproductive toxicology, this revised and updated resource addresses the totality of the subject, discussing a broad range of topics, including nanoparticles and radiation, gases and solvents, smoking, alcohol and drug abuse, and metals, amongst others.

With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, also including discussions on reproductive and developmental toxicity in domestic animals, fish, and wildlife.

Completely revised and updated to include the most recent developments in the field, the book is an essential resource for advanced students and researchers in toxicology, as well as biologists, pharmacologists, and teratologists from academia, industry, and regulatory agencies.

Key Features

  • Provides a complete, up-to-date, integrated source of information on the key risk stages during reproduction and development
  • Includes new chapters covering significant developments, such as dose-response assessment for developmental toxicity, juvenile toxicity, and neural tube defects, as well as emerging science, such as stem cell application, toxicoproteomics, metabolomics, endocrine disruption, surveillance and regulatory considerations, and risk assessment
  • Offers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis


Researchers and advanced students in Toxicology. Also, biologists, pharmacologists, and teratologists from academia, industry, and governmental agencies; domestic, wildlife, and aquatic specialists; environmentalists; regulatory agencies

Table of Contents

Section I: General
1. Introduction
2. Reproductive anatomy and physiology
3. Pharmacokinetics in pregnancy
4. PBPK models in reproductive and developmental toxicology
5. Transfer of drugs and xenobiotics through milk
6. Dose-response assessment for developmental toxicity: Integration and translation

Section II: Toxicity Testing Models and Safety Evaluation
7. Reproductive and developmental safety evaluation of new pharmaceutical compounds
8. Juvenile toxicity: A study of effects of pharmaceuticals on growth, postnatal development and reproduction
9. Postmarket surveillance and regulatory considerations in reproductive and developmental toxicology: An FDA perspective
10. OECD guidelines and validated methods for in vivo testing of reproductive toxicity 
11. Mechanism-based models in reproductive and developmental toxicology 
12. Relevance of animal testing and sensitivity of endpoints in reproductive and developmental toxicity
13. Embryonic toxic lesions and stem cell therapy in chemical-induced developmental toxicities
14. In vitro approaches to developmental neurotoxicity
15. In vitro biomarkers of developmental neurotoxicity
16. Zebrafish model to assess developmental neurotoxicity
17. Caenorhabditis elegans model to assess reproductive and developmental toxicity
18. A primate animal model for reproductive and developmental toxicity testing
19. Developmental immunotoxicity testing

Section III: Nanoparticles and Radiation
20. Developmental toxicity of engineered nanoparticles
21. Effects of radiation on the reproductive system

Section IV: Gases and Solvents
22. Reproductive and developmental toxicology: Toxic solvents and gases

Section V: Drugs of Abuse and Addiction, smoking and alcohol
23. Caffeine
24. Developmental neurotoxicity of abused drugs
25. Effects of alcohol on embryo/fetal development
26. Cigarette smoking and reproductive and developmental toxicity

Section VI: Pharmaceuticals and Food Additives
27. Thalidomide
28. Retinoids
29. Melamine and cyanuric acid
30. Ionophores

Section VII: Metals
31. Boron
32. Arsenic, cadmium and lead
33. Manganese
34. Mercury
35. Selenium

Section VIII: Pesticides, Industrial, and Other Environmental Contaminants
36. Organophosphate and carbamate pesticides
37. Chlorinated hydrocarbons and pyrethrins/pyrethroids
38. Herbicides and fungicides
39. Brominated flame retardants
40. Polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins and polychlorinated Dibenzofurans
41. Reproductive toxicity of polycyclic aromatic hydrocarbons
42. Developmental toxicity of polycyclic aromatic hydrocarbons
43. Bisphenol A
44. Ethylene Glycol
45. Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA)
46. Phthalates
47. Personal care products and cosmetics

Section IX: Phytotoxicants, mycotoxins, and zootoxins
48. Toxic plants
49. Phytoestrogens
50. Fumonisins
51. Trichothecenes and zearalenone
52. Aflatoxins, ochratoxins and citrinin
53. Zootoxins

Section X: Special Topics
54. Building cellular pathways for the future-The virtual embryo
55. Applications of stem cells in developmental toxicology
56. Epigenetic regulation of gene and genome expression
57. Mitochondrial dysfunction in reproductive and developmental toxicity
58. Cell signaling mechanisms in developmental neurotoxicity
59. Neuroinflammation and oxidative injury in developmental neurotoxicity
60. Stress: its impact on reproductive and developmental toxicity
61. Disruption of cholesterol homeostasis in developmental neurotoxicity

Section XI: Endocrine Disruption, Mutagenicity, Carcinogenicity, Infertility and Teratogenicity
62. Endocrine disruptors
63. Developmental and reproductive disorders: role of endocrine disruptors in testicular toxicity
64. Mutagenicity and carcinogenicity: human reproductive cancer and risk factors
65. Neural tube defects: environmental determinants and prevention
66. Teratogenicity
67. Micro-CT and volumetric imaging in developmental toxicology

Section XII: Toxicologic Pathology
68. Toxicologic pathology of the reproductive system

Section XIII: Placental Toxicity
69. The placental role in fetal programming
70. Strategies for investigating hemochorial placentation
71. The significance of ABC transporters in human placenta for the exposure of the fetus to xenobiotics
72. Placental toxicity
73. Placental pathology

Section XIV: Domestic and Wildlife Species
74. Reproductive and developmental toxicity in avian species
75. Endocrine disruption in wildlife species
76. Teratogenesis in livestock


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© Academic Press 2017
Academic Press
Hardcover ISBN:

About the Editor

Ramesh C. Gupta

Dr. Ramesh C. Gupta, Professor & Head of Toxicology Department at Murray State university, is engaged in experimental brain research in relation to Alzheimer(s) disease (AD) and pesticide toxicity. He has delivered lectures in Australia, Italy, Japan, Germany, France, Switzerland, Spain, Czech Republic, China, South Korea, and Sweden. He served the panels of NIH, CDC, NIOSH, and NAS. He has >350 publications to his credit, including six major books: (1) Toxicology of Organophosphate and Carbamate Compounds, (2) Veterinary Toxicology: Basic and Clinical Principles, (3) Handbook of Toxicology of Chemical Warfare Agents, (4) Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology, (5) Reproductive and Developmental Toxicology, and (6) Biomarkers in Toxicology. He is recipient of Murray State University's distinguished researcher award of the year-2006. He is a diplomate of American Board of Toxicology, and fellow of American College of Toxicology, American College of Nutrition, and Academy of Toxicological Sciences.

Affiliations and Expertise

DVM, MVSc, PhD, DABT, FACT, FACN, FATS, Professor and Head, Toxicology Department, Breathitt Veterinary Center, Murray State University, Hopkinsville, KY, USA