Reproductive and Developmental Toxicology

1st Edition

Editors: Ramesh C. Gupta
Authors: Ramesh C. Gupta
Hardcover ISBN: 9780123820327
eBook ISBN: 9780123820334
Imprint: Academic Press
Published Date: 25th February 2011
Page Count: 1220
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Reproductive toxicology is a complex subject dealing with three components—parent, placenta, and fetus—and the continuous changes that occur in each. Reproductive and Developmental Toxicology is a comprehensive and authoritative resource providing the latest literature enriched with relevant references describing every aspect of this area of science. It addresses a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, food additives, nutraceuticals and pharmaceuticals, and metals, among others. With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, and is the only resource to include reproductive and developmental toxicity in domestic animals, fish, and wildlife.

Key Features

  • Provides a complete, integrated source of information on the key risk stages during reproduction and development
  • Includes coverage of emerging science such as stem cell application, toxicoproteomics, metabolomics, phthalates, infertility, teratogenicity, endocrine disruption, surveillance and regulatory considerations, and risk assessment
  • Offers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis


Biologists, pharmacologists, toxicologists, and teratologists from academia, industry, and governmental agencies; domestic, wildlife, and aquatic specialists; environmentalists; regulatory agencies

Table of Contents



List of Contributors

Chapter 1. Introduction

Chapter 2. Reproductive anatomy and physiology

Chapter 3. Bio-communication between mother and offspring

Chapter 4. Pharmacokinetics in pregnancy

Chapter 5. PBPK models in reproductive and developmental toxicology

Chapter 6. Transfer of drugs and xenobiotics through milk

Chapter 7. Postmarket surveillance and regulatory considerations in reproductive and developmental toxicology

Chapter 8. Reproductive and developmental safety evaluation of new pharmaceutical compounds

Chapter 9. Relevance of animal testing and sensitivity of endpoints in reproductive and developmental toxicity

Chapter 10. OECD guidelines and validated methods for in vivo testing of reproductive toxicity

Chapter 11. Mechanism-based models in reproductive and developmental toxicology

Chapter 12. In vitro embryotoxicity testing

Chapter 13. In vitro approaches to developmental neurotoxicity

Chapter 14. Reproductive and developmental toxicity models in relation to neurodegenerative diseases

Chapter 15. Using zebrafish to assess developmental neurotoxicity

Chapter 16. Caenorhabditis elegans as a model to assess reproductive and developmental toxicity

Chapter 17. A primate as an animal model for reproductive and developmental toxicity testing

Chapter 18. Developmental immunotoxicity testing

Chapter 19. In vitro biomarkers of developmental neurotoxicity

Chapter 20. In vivo biomarkers and biomonitoring in reproductive and developmental toxicity

Chapter 21. Developmental toxicity of engineered nanoparticles

Chapter 22. Effects of radiation on the reproductive system

Chapter 23. Reproductive and developmental toxicology: toxic solvents and gases

Chapter 24. Cigarette smoking and reproductive and developmental toxicity

Chapter 25.


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© Academic Press 2011
Academic Press
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About the Editor

Ramesh C. Gupta

Affiliations and Expertise

Professor and Head, Toxicology Department, Breathitt Veterinary Center, Murray State University, Hopkinsville, KY, USA

About the Author

Ramesh C. Gupta

Dr. Ramesh C. Gupta, Professor & Head of Toxicology Department at Murray State university, is engaged in experimental brain research in relation to Alzheimer(s) disease (AD) and pesticide toxicity. He has delivered lectures in Australia, Italy, Japan, Germany, France, Switzerland, Spain, Czech Republic, China, South Korea, and Sweden. He served the panels of NIH, CDC, NIOSH, and NAS. He has >350 publications to his credit, including six major books: (1) Toxicology of Organophosphate and Carbamate Compounds, (2) Veterinary Toxicology: Basic and Clinical Principles, (3) Handbook of Toxicology of Chemical Warfare Agents, (4) Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology, (5) Reproductive and Developmental Toxicology, and (6) Biomarkers in Toxicology. He is recipient of Murray State University's distinguished researcher award of the year-2006. He is a diplomate of American Board of Toxicology, and fellow of American College of Toxicology, American College of Nutrition, and Academy of Toxicological Sciences.

Affiliations and Expertise

DVM, MVSc, PhD, DABT, FACT, FACN, FATS, Professor and Head, Toxicology Department, Breathitt Veterinary Center, Murray State University, Hopkinsville, KY, USA


"Overall, this book will be very useful as an authoritative source of critically analyzed information for anybody seeking insight into reproductive and developmental physiology and its perturbation by a vast array of endogenous and environmental factors."--Frank Welsch, D.V.M., Ph.D., D.A.B.T., Principal Scientist, Orbitox International Toxicology Consultants


"Reproductive and Developmental Toxicology provides comprehensive coverage of historical and current knowledge in this specialized field of toxicology. It comprises 86 chapters approaches and model systems are described by experts in the field. Several subsequent sections provide historical and current information on a number of developmental toxicants, including nanoparticles and radiation; gases and solvents; smoking, alcohol, and drugs of addiction; food additives, metals, and pesticides; and phytotoxins and biotoxins. Each chapter is well organized, with an introduction, a full description of the characteristics, mechanisms where known, effects of each toxicant, and concluding remarks and future directions. Figures are used effectively and strategically to illustrate a number of topics…. The contributors to Reproductive and Developmental Toxicology are an international group of almost 180 scientists, who represent academic institutions, pharmaceutical industries, and governmental agencies. They provide an exceptional breadth of expertise in the wide range of topics covered in this extensive volume. This book will be most useful to the scientifically trained reader seeking a detailed understanding of the experimental background and currently studied topics of reproductive and developmental toxicology."--Veterinary Pathology Online


"The 15 sections in the book comprehensively cover a wide range of crucial aspects of developmental and reproductive t