Reproductive and Developmental Toxicology - 1st Edition - ISBN: 9780123820327, 9780123820334

Reproductive and Developmental Toxicology

1st Edition

Editors: Ramesh C. Gupta
Authors: Ramesh C. Gupta
eBook ISBN: 9780123820334
Hardcover ISBN: 9780123820327
Imprint: Academic Press
Published Date: 25th February 2011
Page Count: 1220
Tax/VAT will be calculated at check-out
30% off
30% off
30% off
30% off
30% off
20% off
20% off
30% off
30% off
30% off
30% off
30% off
20% off
20% off
25% off
25% off
25% off
25% off
25% off
20% off
20% off
File Compatibility per Device

PDF, EPUB, VSB (Vital Source):
PC, Apple Mac, iPhone, iPad, Android mobile devices.

Amazon Kindle eReader.

Institutional Access


Reproductive toxicology is a complex subject dealing with three components—parent, placenta, and fetus—and the continuous changes that occur in each. Reproductive and Developmental Toxicology is a comprehensive and authoritative resource providing the latest literature enriched with relevant references describing every aspect of this area of science. It addresses a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, food additives, nutraceuticals and pharmaceuticals, and metals, among others. With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, and is the only resource to include reproductive and developmental toxicity in domestic animals, fish, and wildlife.

Key Features

  • Provides a complete, integrated source of information on the key risk stages during reproduction and development
  • Includes coverage of emerging science such as stem cell application, toxicoproteomics, metabolomics, phthalates, infertility, teratogenicity, endocrine disruption, surveillance and regulatory considerations, and risk assessment
  • Offers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis


Biologists, pharmacologists, toxicologists, and teratologists from academia, industry, and governmental agencies; domestic, wildlife, and aquatic specialists; environmentalists; regulatory agencies

Table of Contents



List of Contributors

Chapter 1. Introduction

Chapter 2. Reproductive anatomy and physiology

Chapter 3. Bio-communication between mother and offspring

Chapter 4. Pharmacokinetics in pregnancy

Chapter 5. PBPK models in reproductive and developmental toxicology

Chapter 6. Transfer of drugs and xenobiotics through milk

Chapter 7. Postmarket surveillance and regulatory considerations in reproductive and developmental toxicology

Chapter 8. Reproductive and developmental safety evaluation of new pharmaceutical compounds

Chapter 9. Relevance of animal testing and sensitivity of endpoints in reproductive and developmental toxicity

Chapter 10. OECD guidelines and validated methods for in vivo testing of reproductive toxicity

Chapter 11. Mechanism-based models in reproductive and developmental toxicology

Chapter 12. In vitro embryotoxicity testing

Chapter 13. In vitro approaches to developmental neurotoxicity

Chapter 14. Reproductive and developmental toxicity models in relation to neurodegenerative diseases

Chapter 15. Using zebrafish to assess developmental neurotoxicity

Chapter 16. Caenorhabditis elegans as a model to assess reproductive and developmental toxicity

Chapter 17. A primate as an animal model for reproductive and developmental toxicity testing

Chapter 18. Developmental immunotoxicity testing

Chapter 19. In vitro biomarkers of developmental neurotoxicity

Chapter 20. In vivo biomarkers and biomonitoring in reproductive and developmental toxicity

Chapter 21. Developmental toxicity of engineered nanoparticles

Chapter 22. Effects of radiation on the reproductive system

Chapter 23. Reproductive and developmental toxicology: toxic solvents and gases

Chapter 24. Cigarette smoking and reproductive and developmental toxicity

Chapter 25. Effects of ethanol and nicotine on human CNS development

Chapter 26. Developmental neurotoxicity of abused drugs

Chapter 27. Caffeine

Chapter 28. Melamine and cyanuric acid

Chapter 29. Ionophores

Chapter 30. Selected herbal supplements and nutraceuticals

Chapter 31. Thalidomide

Chapter 32. Aluminum

Chapter 33. Arsenic, cadmium and lead

Chapter 34. Manganese

Chapter 35. Mercury

Chapter 36. Selenium

Chapter 37. Organophosphate and carbamate pesticides

Chapter 38. Chlorinated hydrocarbons and pyrethrins/pyrethroids

Chapter 39. Herbicides and fungicides

Chapter 40. Brominated flame retardants

Chapter 41. Polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans

Chapter 42. Developmental dioxin exposure and endometriosis

Chapter 43. Reproductive toxicity of polycyclic aromatic hydrocarbons

Chapter 44. Developmental toxicity of polycyclic aromatic hydrocarbons

Chapter 45. Ethylene glycol

Chapter 46. Methyl tert-butyl ether

Chapter 47. Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA)

Chapter 48. Phthalates

Chapter 49. Organotins (tributyltin and triphenyltin)

Chapter 50. Bisphenol A

Chapter 51. Toxic plants

Chapter 52. Phytoestrogens

Chapter 53. Fumonisins

Chapter 54. Trichothecenes and zearalenone

Chapter 55. Aflatoxins, ochratoxins and citrinin

Chapter 56. Zootoxins

Chapter 57. HIV-1 Tat toxin

Chapter 58. Applications of stem cells in developmental toxicology

Chapter 59. Applications of toxicogenomics in reproductive and developmental toxicology

Chapter 60. Epigenetic regulation of gene and genome expression

Chapter 61. Mitochondrial dysfunction in reproductive and developmental toxicity

Chapter 62. Stress: its impact on reproductive and developmental toxicity

Chapter 63. Cell signaling mechanisms in developmental neurotoxicity

Chapter 64. Neuroinflammation and oxidative injury in developmental neurotoxicity

Chapter 65. Disruption of cholesterol homeostasis in developmental neurotoxicity

Chapter 66. Cholinergic Toxicity and the Male Reproductive System

Chapter 67. Endocrine disruptors

Chapter 68. Screening systems for endocrine disruptors

Chapter 69. Developmental and reproductive disorders

Chapter 70. Mutagenicity and carcinogenicity

Chapter 71. Genotoxicities and infertility

Chapter 72. Occupational exposure to chemicals and reproductive health

Chapter 73. Teratogenicity

Chapter 74. Ultrasound and magnetic resonance in prenatal diagnosis of congenital anomalies

Chapter 75. Micro-CT and volumetric imaging in developmental toxicology

Chapter 76. Toxicologic pathology of the reproductive system

Chapter 77. Strategies for investigating hemochorial placentation

Chapter 78. The placental role in fetal programming

Chapter 79. The significance of ABC transporters in human placenta for the exposure of the fetus to xenobiotics

Chapter 80. Placental toxicity

Chapter 81. Placental pathology

chapter 82. Reproductive and developmental toxicity in avian species

Chapter 83. Endocrine disruption in wildlife species

Chapter 84. Teratogeneses in livestock

Chapter 85. Mare reproductive loss syndrome

Chapter 86. Reproductive and developmental toxicity in fishes

Color Plates



No. of pages:
© Academic Press 2011
Academic Press
eBook ISBN:
Hardcover ISBN:

About the Editor

Ramesh C. Gupta

Affiliations and Expertise

Professor and Head, Toxicology Department, Breathitt Veterinary Center, Murray State University, Hopkinsville, KY, USA

About the Author

Ramesh C. Gupta

Dr. Ramesh C. Gupta, Professor & Head of Toxicology Department at Murray State university, is engaged in experimental brain research in relation to Alzheimer(s) disease (AD) and pesticide toxicity. He has delivered lectures in Australia, Italy, Japan, Germany, France, Switzerland, Spain, Czech Republic, China, South Korea, and Sweden. He served the panels of NIH, CDC, NIOSH, and NAS. He has >350 publications to his credit, including six major books: (1) Toxicology of Organophosphate and Carbamate Compounds, (2) Veterinary Toxicology: Basic and Clinical Principles, (3) Handbook of Toxicology of Chemical Warfare Agents, (4) Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology, (5) Reproductive and Developmental Toxicology, and (6) Biomarkers in Toxicology. He is recipient of Murray State University's distinguished researcher award of the year-2006. He is a diplomate of American Board of Toxicology, and fellow of American College of Toxicology, American College of Nutrition, and Academy of Toxicological Sciences.

Affiliations and Expertise

DVM, MVSc, PhD, DABT, FACT, FACN, FATS, Professor and Head, Toxicology Department, Breathitt Veterinary Center, Murray State University, Hopkinsville, KY, USA


"Overall, this book will be very useful as an authoritative source of critically analyzed information for anybody seeking insight into reproductive and developmental physiology and its perturbation by a vast array of endogenous and environmental factors."--Frank Welsch, D.V.M., Ph.D., D.A.B.T., Principal Scientist, Orbitox International Toxicology Consultants


"Reproductive and Developmental Toxicology provides comprehensive coverage of historical and current knowledge in this specialized field of toxicology. It comprises 86 chapters approaches and model systems are described by experts in the field. Several subsequent sections provide historical and current information on a number of developmental toxicants, including nanoparticles and radiation; gases and solvents; smoking, alcohol, and drugs of addiction; food additives, metals, and pesticides; and phytotoxins and biotoxins. Each chapter is well organized, with an introduction, a full description of the characteristics, mechanisms where known, effects of each toxicant, and concluding remarks and future directions. Figures are used effectively and strategically to illustrate a number of topics…. The contributors to Reproductive and Developmental Toxicology are an international group of almost 180 scientists, who represent academic institutions, pharmaceutical industries, and governmental agencies. They provide an exceptional breadth of expertise in the wide range of topics covered in this extensive volume. This book will be most useful to the scientifically trained reader seeking a detailed understanding of the experimental background and currently studied topics of reproductive and developmental toxicology."--Veterinary Pathology Online


"The 15 sections in the book comprehensively cover a wide range of crucial aspects of developmental and reproductive toxicology as relates to experimental models commonly used in pharmaceutical, agro-chemical and environmental toxicology research. Excellent examples of normal and abnormal outcomes of reproductive toxicity are presented, especially in the color plates in the last few pages of the book. This book is an excellent reference for both seasoned toxicologists, those entering the practice of toxicology and students." --Dr. Norbert Makori, DART Director, SNBL USA, Ltd., Everett, WA