Reproduction of Eukaryotic Cells

Reproduction of Eukaryotic Cells

1st Edition - January 28, 1976

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  • Author: David Prescott
  • eBook ISBN: 9780323160520

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Reproduction of Eukaryotic Cells organizes in a single source the principal facts and observations on the cell life cycle and reproduction of eukaryotic cells. The aim is to increase the overall understanding of how these cells reproduce themselves and how this reproduction is regulated. The book begins with a discussion of the sections of the cell cycle and regulation of cell reproduction. Separate chapters on cell growth, cell synchrony, the G1 period, S period, and G2 period follow. Subsequent chapters are devoted to activities during cell division; cell cycle changes in surface morphology; the role of cyclic AMP (cAMP) and cyclic GMP (cGMP) in regulation of cell reproduction; and changes in nuclear proteins, RNA synthesis, and enzyme activities during the cell cycle. The final chapter covers the genetic analysis of the cell cycle.

Table of Contents

  • Preface

    1 Introduction

    Sections of the Cell Cycle

    Regulation of Cell Reproduction

    2 Cell Growth through the Cycle

    Fission Yeast (Schizosaccharomyces pombe)

    Amoeba proteus

    Tetrahymena pyriformis

    Mouse Fibroblast


    3 Cell Synchrony

    Natural Synchrony

    Experimentally Derived Synchrony

    4 The G1 Period

    Variableness of G1

    Relation of Cell Growth to the Length of G1

    Control of Cell Reproduction in G1

    Requirements for Protein and RNA Synthesis to Complete G1

    Preparation for DNA Synthesis

    5 Initiation of the S Period

    Role of Nuclear-Cytoplasmic Interactions in DNA Synthesis

    Intranuclear Site of Initiation and Continuation of DNA Synthesis

    6 The S Period

    The Number of Replicating Units (Replicons)

    Minimum Number of Replicon Families

    Apparent Change in the Number of Origins of Replication in Relation to Development

    The Ordering of DNA Replication

    Requirements for Protein and RNA Synthesis during the S Period

    The Length of the S Period in Cells of Different Ploidies

    7 The G2 Period

    Preparation for Mitosis

    Arrest of the Cycle in G2

    Requirements for Protein and RNA Syntheses during G2

    The G2 to D Transition

    8 Activities during Cell Division

    RNA Synthesis during Mitosis

    Protein Synthesis during Mitosis

    Reversible Shift of Nuclear RNA and Protein to the Cytoplasm during Mitosis

    9 Cell Surface Changes during the Cycle

    Morphological Changes

    Chemical Changes of the Plasma Membrane

    Plant Lectin Binding and Cell Agglutinability

    10 Cyclic AMP, Cyclic GMP, and Cell Reproduction

    cAMP and the Cell Cycle

    Effects of Experimentally Induced Increases in Intracellular cAMP on Cell Growth

    Cyclic Nucleotides and the Imposition and Release of G1 Arrest

    Regulation of cAMP Levels in Cells

    11 Nuclear Proteins and the Cell Cycle


    Nonhistone Nuclear Proteins

    12 RNA Synthesis and the Cell Cycle


    13 Patterns of Enzyme Activities through the Cell Cycle


    14 The Genetics of the Cell Cycle

    How Much of the Genome Is Specifically Concerned with the Cell Cycle?

    Genetic Analysis of the Cell Cycle in Yeast

    Genetic Analysis of the Cell Cycle in Mammalian Cells

    The Concept of Regulatory Genes for Cell Reproduction

    Final Comment



Product details

  • No. of pages: 187
  • Language: English
  • Copyright: © Academic Press 1976
  • Published: January 28, 1976
  • Imprint: Academic Press
  • eBook ISBN: 9780323160520

About the Author

David Prescott

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