Relative Radiation Sensitivities of Human Organ Systems

Relative Radiation Sensitivities of Human Organ Systems

1st Edition - September 8, 1994

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  • Editors: Kurt I. Altman, John T. Lett
  • eBook ISBN: 9781483282312

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Advances in Radiation Biology, Volume18: Relative Radiation Sensitivities of Human Organ Systems, Part IV focuses on the sensitivity of certain human organ systems to radiation exposure. This book discusses the radiation sensitivity of the prostate and radiation therapy of its tumors; clinical radiobiology and normal-tissue morbidity after breast cancer treatment; and approach to optimal therapy and normal-tissue sparing. The fractionation sensitivity of mammalian tissues; trends for improving radiation sensitivity by counteracting chronic and acute hypoxia; and predictive assays in radiation therapy are also elaborated. This publication likewise covers the basic cellular radiobiology and its significance for radiation therapy and classical theoretical approaches to cellular radiosensitivity. This volume is beneficial to clinicians and students intending to gain knowledge of the radiation sensitivities of human organ systems.

Table of Contents

  • Contents of Volumes 12, 14, and 15 (Parts I, II, and III of the Four-Part Series, "Relative Radiation Sensitivities of Human Organ Systems")

    Radiation Sensitivity of the Prostate and Radiation Therapy of Its Tumors

    I. Introduction

    II. Biological Background of Radiotherapy of the Prostate

    III. External Beam Radiotherapy

    IV. Brachytherapy

    V. Palliative Radiotherapy

    VI. Summary and Conclusion


    Note Added in Proof

    Clinical Radiobiology and Normal-Tissue Morbidity after Breast Cancer Treatment

    I. Introduction

    II. Clinical Radiobiology of Normal Tissues

    III. Late Normal-Tissue Sequelae after Breast Treatment

    IV. Concluding Remarks


    Proton-Beam Irradiation for the Cancer Patient: An Approach to Optimal Therapy and Normal-Tissue Sparing

    I. Introduction

    II. Critical Concepts, Events, and Decisions

    III. Accelerator

    IV. Beam Delivery System

    V. Microdosimetry

    VI. Radiation Biology

    VII. Clinical Applications

    VIII. Conclusion


    Fractionation Sensitivity of Mammalian Tissues

    I. Introduction

    II. Fractionation Sensitivity of Skin and Mucosa

    III. Fractionation Sensitivity of the Lung

    IV. Fractionation Sensitivity of the Spinal Cord

    V. Fractionation Sensitivity of the Digestive Tract

    VI. Fractionation Sensitivity of the Bone Marrow

    VII. Fractionation Sensitivity of the Kidney

    VIII. Fractionation Sensitivity of the Liver

    IX. Fractionation Sensitivity of the Lens

    X. Conclusion


    New Trends for Improving Radiation Sensitivity by Counteracting Chronic and Acute Hypoxia

    I. Importance of Hypoxia in Experimental and Human Tumors

    II. New Trends for Radiosensitizing Hypoxic Cells

    III. New Trends for Improving Radiotherapy through Hypoxia

    IV. Conclusions


    Predictive Assays in Radiation Therapy

    I. Introduction

    II. Intrinsic Radiosensitivity

    III. Cell Kinetics

    IV. Ploidy

    V. Hypoxia

    VI. Examples of Other Potential Prognostic Factors

    VII. Assessment of Predictive Assays

    VIII. Summary and Conclusions


    The Renaissance in Basic Cellular Radiobiology and Its Significance for Radiation Therapy

    I. Introduction

    II. Discovery of Cellular Recovery Processes

    III. Classical Theoretical Approaches to Cellular Radiosensitivity

    IV. Introduction to Modem Approaches to Cellular Radiosensitivity

    V. Chemical Basis of Cellular Radiosensitivity: General Considerations

    VI. Models of Cellular Radiation Targets

    VII. Formulation of Cellular Survival Curves with Enzyme Kinetics: An Introduction

    VIII. Conclusions



Product details

  • No. of pages: 242
  • Language: English
  • Copyright: © Academic Press 1994
  • Published: September 8, 1994
  • Imprint: Academic Press
  • eBook ISBN: 9781483282312

About the Editors

Kurt I. Altman

John T. Lett

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