Relative Radiation Sensitivities of Human Organ Systems

Relative Radiation Sensitivities of Human Organ Systems

1st Edition - May 6, 1992

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  • Editors: Kurt I. Altman, John T. Lett
  • eBook ISBN: 9781483281841

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Advances in Radiation Biology: Relative Radiation Sensitivities of Human Organ Systems, Part III, is the third volume of the series "Relative Radiation Sensitivities of Human Organ Systems." It presents reviews of organ systems not included in the preceding two parts (Advances in Radiation Biology, Volumes 12 and 14). The subject matter contained in the current volume is viewed through the eyes of the radiation therapist. Although the presentations have strong clinical overtones, an effort has been made, wherever possible, also to address the radiobiological bases of radiation sensitivity of organs. The book contains seven chapters and begins with a study on radiation damage to the kidney. This is followed by separate chapters on inherent or intrinsic radiosensitivity of human cells; the impact of brachytherapy (i.e., short-distance radiation treatment using photon radiation) on tumors; and human tissue tolerance to fast neutron radiotherapy. Subsequent chapters deal with normal tissue effects of combined hyperthermia and radiotherapy; the impact of ionizing radiation on the successive stages of human development in utero; and developments in theoretical knowledge and practical applications of ionizing radiations which have taken place in a little less than a century.

Table of Contents

  • Preface

    Contents of Volumes 12 and 14 (Parts I and II of "Relative Radiation Sensitivities of Human Organ Systems")

    Radiation Damage to the Kidney

    I. Introduction

    II. Radiation Damage to Normal Tissue: Basic Principles

    III. Functional Anatomy of the Kidney

    IV. Damage at the Cellular Level

    V. Radiation Histopathology of the Kidney

    VI. Clinical Radiation Nephropathy

    VII. Animal Experiments

    VIII. Conclusions


    Intrinsic Radiosensitivity of Human Cells

    I. Introduction

    II. Fitting the Survival Curves

    III. Intrinsic Radiosensitivity of Human Tumor Cells: A Determinant of Clinical Radioresponsiveness

    IV. Intrinsic Radiosensitivity of Nontransformed Human Fibroblasts

    V. Predictive Assays

    VI. Role of Transformation in the Intrinsic Radiosensitivity of Human Cells

    VII. Recovery, Repair, and Intrinsic Radiosensitivity

    VIII. Conclusion


    Relative Sensitivities of Tumors to Brachytherapy

    I. Introduction

    II. Radiobiology

    III. Radiobiology of High-LET Neutron Brachytherapy

    IV. New Brachytherapy

    V. Second Tumors after Brachytherapy

    VI. Clinical State of the Art

    VII. Summary and Conclusions


    Fast Neutron Radiotherapy in Relation to the Radiation Sensitivity of Human Organ Systems

    I. Introduction

    II. Radiotherapy Complications in Various Tissues

    III. Survey of Neutron Treatment Facilities

    IV. Concluding Remarks


    Normal Tissue Effects of Hyperthermia in Conjunction with Radiotherapy

    I. Introduction

    II. Cellular and Physiological Features of Hyperthermia

    III. Normal Tissue Effects in Animal Models: Hyperthermia Alone

    IV. Radiation with Hyperthermia: In Vivo Animal Studies

    V. Clinical Studies on Humans

    VI. Discussion


    Expectation of Malformations after Irradiation of the Developing Human in Utero: The Experimental Basis for Predictions

    I. Introduction

    II. Early Mammalian Development

    III. Inactivation by Radiation at Specific Developmental Stages

    IV. Malformations as a Consequence of Irradiation in Utero

    V. Irradiation at the Preimplantation Stage: The Mouse

    VI. Irradiation at the Preimplantation Stage: The Rat

    VII. Irradiation during Organogenesis: The Mouse

    VIII. Irradiation during Organogenesis: The Rat

    IX. Other Species

    X. Quantitative Changes in Malformations during Life in Utero

    XI. Influence of Protraction and/or Fractionation of Exposure

    XII. Exposure to Fast Neutrons

    XIII. Human Experience of Radiation in Utero

    XIV. Conclusions


    Radiation Research: A Joint Venture in Radiobiology and Radiotherapy

    I. Introduction

    II. Early Discoveries

    III. Discoveries from the 1950s to the Present



Product details

  • No. of pages: 340
  • Language: English
  • Copyright: © Academic Press 1992
  • Published: May 6, 1992
  • Imprint: Academic Press
  • eBook ISBN: 9781483281841

About the Editors

Kurt I. Altman

John T. Lett

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