Regulatory T Lymphocytes

Regulatory T Lymphocytes documents the proceedings of a symposium on ""Regulatory T Lymphocytes"" held at Arden House on the Harriman Campus of Columbia University from June 8-10, 1979. The meeting was the fourth of the P&S Biomedical Sciences Symposia.
Starting with the opening address on regulatory T lymphocytes and their antigen receptors, the remainder of the book presents the contributions made by researchers at the symposium. These contributions are organized into seven parts. Part I contains studies T cell receptors. Part II presents studies on T cell subpopulations. Parts III and IV examine helper T cells. Parts V and VI deal with suppressor T cells. Part VII contains papers on regulatory T cell circuits.

List of Participants

Preface

Opening Address

Regulatory T Lymphocytes and Their Antigen Receptors

Introduction

The Regulatory T Cells

The T Cell Regulatory Networks

The T Cell Receptor

The Effect of Anti-Cri and Cri Coupled Cells on ABA DTH

Hapten-Specific T Cell Responses to 4-Hydroxy-3-Nitrophenyl Acetyl (NP)-Genetic Control of DTH by VH and I-A Region Genes

References

Part I T Cell Receptors

Generation and Analysis of T Cell Clones That Secrete Antigen-Specific Polypeptides Mediating Different T Cell Functions

Introduction

Results

Discussion

Conclusion

References

Immunochemical Properties of Isolated Hapten-Specific T Cell Receptor Molecules

Introduction

Material and Methods

Results

Discussion

References

Epitope-Binding Molecules from Azobenzenearsonate-Specific Murine T Cells

Introduction

Induction of ABA-Specific Helper and Suppressor Activity in A/J Mice

Purification of ABA-Specific T Cells

Properties of Affinity-Enriched ABA-Binding T Cells

Biosynthetic Labeling of Cell Proteins with 35S-Methionine

ABA-Specific Affinity Chromatography

SDS-PAGE Analysis of T Cell-Derived ABA-Binding Molecules

T Cell-Derived p92 Molecules Lack Classic Immunoglobulin Determinants

Antigen-Specific Suppressor Activity of 92 KD T Cell Products

Preparation of T Cell Hybrids

T Cell Antigen Receptors and Effector Molecules

References

T Cell Mediated Immune Response to Anti-MHC Receptors

Introduction

Immunogenicity of Anti-MHC Receptors on T Cells

Anti-MHC T Cell Receptors Display "Idiotypic" Determinants Which are Specificity Associated and Nonpolymorphic

Induced Tolerance in F Rats to Anti-MHC Receptors on Parental T Cells Another Manifestation of Receptor Antigenicity

Discussion

References

Part II T Cell Subpopulations

Expression of la Antigens on T Lymphocytes

Introduction

Experiments with Functionally Defined T Cell Subpopulations

Treatment with Anti-la Sera in Vivo

Direct Evidence for the Expression of la Antigens on T Cells

Conclusions

References

Analysis of Lymphocyte Subpopulations with Monoclonal Antibodies to Thy-1, Lyt-1, Lyt-2, and ThB Antigens

Introduction

Materials and Methods

Results

Discussion

References

Immunoregulation by Human Lymphocyte Subpopulations

Introduction

Normal Human B Cell Immunoregulation

Abnormalities of Immunoregulatory T Cell Subpopulations in Selected Disease States

Summary and Conclusions

References

Part III Helper T Cells (Murine)

Regulation of the Immune Response to Cell Surface Antigens

T -B Cooperation: Factors or Cell Contacts?

Intrastructural, Intermolecular Help

Intrastructural, Intermolecular Inhibition

How Many Antigen-Presenting Cells?

References

Synergizing Helper T Cell Sets and the Regulation of Antibody Quality

Introduction

Results and Discussion

Summary and Conclusions

References

Expression of Idiotype-Like Determinants on Hapten-Specific, MHC-Restricted T Helper Cells, Enrich in Vitro

Introduction

Methods and Results

Discussion

References

Cooperation Subsets of Antigen -Specific Helper T Cells

Methods and Results

Discussion

References

T-B Collaboration in Vivo: Role of the Major Histocompatibility Complex

Introduction

Discussion

References

Functions of Two Helper T Cells Distinguished by Anti-la Antisera

Introduction

Materials and Methods

Results

Discussion

Summary

References

Part IV Helper T Cells (Human)

Activation of Human B Lymphocytes by MLR-Derived Helper Factors and Anti-Immunoglobulins

Introduction

Effects of Allogeneic Helper Factors on Human B Lymphocyte Differentiation to Plasma Cells

Evidence That Helper Factors Can Induce B Cell Differentiation in the Absence of Autologous T Cells

Mitogenic Properties of Allogeneic Helper Factors

Generation of Helper Factors in Autologous Mixed Lymphocyte Reactions

Effects of Anti-Immunoglobulins and MLR-Derived Helper Factors on Human B Cell Differentiation

Summary

References

Heteroantibodies to Human T Cell Tumors: Recognition of Normal and Malignant T Cell Subsets

Introduction

Preparation and Characterization of Anti-Human Lymphoma Sera

Functional Analysis of Normal T Cell Subsets Bearing Od Determinants

Functional Characterization of Human T Cell Lymphomas

Summary

References

T Cell Helper Factors in Man

Introduction

Lymphocyte Mitogenic Factor

Human Antigen-Specific T Cell Helper Factor (ASF)

Conclusions

References

Regulatory Interactions of Human T Cells

Characteristics of TM and TG Cells

Helper and Suppressor Control of B Cell Responses

Mechanism by Which TG Cells Suppress B Cell Differentiation

Lineal Relationship of TM and TG Cells

T Cell Malignancies

Alteration of Circulating TM and TG Cells in Immunological Disorders

References

Part V Suppressor T Cells (Murine)

The Appearance of 460-Idiotype (460-Id )-Bearing Anti-TNP Antibodies Is Regulated by Suppressor T Cells Specific for 460-Id

Expression of the 460-Id by Anti-TNP Antibodies

T Cell Regulation of the 460-Id 10; Component of the Anti-TNP-PFC Response to TNP-NWSM

Specificity of Suppressor T Cells

Phenotype and Site of Action of 460-Id-Specific Suppressor T Cells

Relationship between Occurrence of 460-Id-Specific Suppressor T Cells and IgCHα Allotype

Enhancement of the 460-Id+ Component of the Anti-TNP Response by Anti-(Anti-460-Id) Anti-Idiotype Antibodies

Conclusions

References

Regulatory T Cell Subsets: Functions in Responses to an Antigen Under Ir Gene Control

Introduction

Experimental System

Regulatory T Cell Subsets Generated by Immunization with Syngeneic and

Allogeneic Gat-Macrophages

Regulatory T Cell Subsets in Spleen Cells from (Responder x Nonresponder) F1 Mice

Discussion

References

Induction of Allotype Suppression with Monoclonal Antibodies

Introduction

Results

Discussion

References

MHC Restriction and Positive Selection of T Suppressor Cells Revealed by Mixture with Inducer T Cells

Introduction

Materials and Methods

Results

Discussion

Summary

References

Part VI Suppressor T Cells (Human)

Characterization of Regulatory T Cells in Man

Introduction

T Cell Subsets in Man

Summary: A Network of T Cell Subsets

References

Suppressor Cell Populations in Normal and Immunodeficient Humans

Introduction

Methods

Results and Discussion

Conclusions

References

Disorders of Suppressor T Cells in Immunodeficiency and Malignancy

In Vitro Methods Used for the Study of Human Helper and Suppressor Activity

Leukemias of the T Cell System That Retain Immunoregulatory Functions

T Cell Neoplasms Which May Retain Helper Activity

Neoplasms of Cells of the Suppressor T Cell Network

T Suppressor Cells in the Bursectomized Bird Model of Agammaglobulinemia

Disorders of Suppressor T Cells Associated with Primary Immunodeficiency Diseases

Implications for Immunoprophylaxis and Immunotherapy

Summary

References

Part VII Regulatory T Cell Circuits

The Generation of Effector Functions as a Result of Communication Between Subclasses of T Lymphocytes

Introduction

Lymphocyte Subpopulations Participating in the Generation of Cytotoxic T Cells

Suppression of T Helper Cells But Not of B Cells by Idiotype-Specific Suppressor T Cells

Recognition of Idiotype as a Means for Lymphocytes to Communicate

Conclusions

References

Regulatory Circuits and Affinity Maturation

Introduction

The Core Regulatory Circuit (CRC)

Auxiliary Regulatory Circuits

Helper T Cells in the ARC's

ARC Control of Affinity Maturation

Applying the Circuit Model to Reality

Memory B Cell Development and Affinity Maturation

References

Index