Regulatory T Lymphocytes

Regulatory T Lymphocytes

1st Edition - January 1, 1980

Write a review

  • Editor: Benvenuto Pernis
  • eBook ISBN: 9780323149099

Purchase options

Purchase options
DRM-free (PDF)
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order

Description

Regulatory T Lymphocytes documents the proceedings of a symposium on ""Regulatory T Lymphocytes"" held at Arden House on the Harriman Campus of Columbia University from June 8-10, 1979. The meeting was the fourth of the P&S Biomedical Sciences Symposia. Starting with the opening address on regulatory T lymphocytes and their antigen receptors, the remainder of the book presents the contributions made by researchers at the symposium. These contributions are organized into seven parts. Part I contains studies T cell receptors. Part II presents studies on T cell subpopulations. Parts III and IV examine helper T cells. Parts V and VI deal with suppressor T cells. Part VII contains papers on regulatory T cell circuits.

Table of Contents


  • List of Participants

    Preface

    Opening Address

    Regulatory T Lymphocytes and Their Antigen Receptors

    Introduction

    The Regulatory T Cells

    The T Cell Regulatory Networks

    The T Cell Receptor

    The Effect of Anti-Cri and Cri Coupled Cells on ABA DTH

    Hapten-Specific T Cell Responses to 4-Hydroxy-3-Nitrophenyl Acetyl (NP)-Genetic Control of DTH by VH and I-A Region Genes

    References

    Part I T Cell Receptors

    Generation and Analysis of T Cell Clones That Secrete Antigen-Specific Polypeptides Mediating Different T Cell Functions

    Introduction

    Results

    Discussion

    Conclusion

    References

    Immunochemical Properties of Isolated Hapten-Specific T Cell Receptor Molecules

    Introduction

    Material and Methods

    Results

    Discussion

    References

    Epitope-Binding Molecules from Azobenzenearsonate-Specific Murine T Cells

    Introduction

    Induction of ABA-Specific Helper and Suppressor Activity in A/J Mice

    Purification of ABA-Specific T Cells

    Properties of Affinity-Enriched ABA-Binding T Cells

    Biosynthetic Labeling of Cell Proteins with 35S-Methionine

    ABA-Specific Affinity Chromatography

    SDS-PAGE Analysis of T Cell-Derived ABA-Binding Molecules

    T Cell-Derived p92 Molecules Lack Classic Immunoglobulin Determinants

    Antigen-Specific Suppressor Activity of 92 KD T Cell Products

    Preparation of T Cell Hybrids

    T Cell Antigen Receptors and Effector Molecules

    References

    T Cell Mediated Immune Response to Anti-MHC Receptors

    Introduction

    Immunogenicity of Anti-MHC Receptors on T Cells

    Anti-MHC T Cell Receptors Display "Idiotypic" Determinants Which are Specificity Associated and Nonpolymorphic

    Induced Tolerance in F Rats to Anti-MHC Receptors on Parental T Cells Another Manifestation of Receptor Antigenicity

    Discussion

    References

    Part II T Cell Subpopulations

    Expression of la Antigens on T Lymphocytes

    Introduction

    Experiments with Functionally Defined T Cell Subpopulations

    Treatment with Anti-la Sera in Vivo

    Direct Evidence for the Expression of la Antigens on T Cells

    Conclusions

    References

    Analysis of Lymphocyte Subpopulations with Monoclonal Antibodies to Thy-1, Lyt-1, Lyt-2, and ThB Antigens

    Introduction

    Materials and Methods

    Results

    Discussion

    References

    Immunoregulation by Human Lymphocyte Subpopulations

    Introduction

    Normal Human B Cell Immunoregulation

    Abnormalities of Immunoregulatory T Cell Subpopulations in Selected Disease States

    Summary and Conclusions

    References

    Part III Helper T Cells (Murine)

    Regulation of the Immune Response to Cell Surface Antigens

    T -B Cooperation: Factors or Cell Contacts?

    Intrastructural, Intermolecular Help

    Intrastructural, Intermolecular Inhibition

    How Many Antigen-Presenting Cells?

    References

    Synergizing Helper T Cell Sets and the Regulation of Antibody Quality

    Introduction

    Results and Discussion

    Summary and Conclusions

    References

    Expression of Idiotype-Like Determinants on Hapten-Specific, MHC-Restricted T Helper Cells, Enrich in Vitro

    Introduction

    Methods and Results

    Discussion

    References

    Cooperation Subsets of Antigen -Specific Helper T Cells

    Methods and Results

    Discussion

    References

    T-B Collaboration in Vivo: Role of the Major Histocompatibility Complex

    Introduction

    Discussion

    References

    Functions of Two Helper T Cells Distinguished by Anti-la Antisera

    Introduction

    Materials and Methods

    Results

    Discussion

    Summary

    References

    Part IV Helper T Cells (Human)

    Activation of Human B Lymphocytes by MLR-Derived Helper Factors and Anti-Immunoglobulins

    Introduction

    Effects of Allogeneic Helper Factors on Human B Lymphocyte Differentiation to Plasma Cells

    Evidence That Helper Factors Can Induce B Cell Differentiation in the Absence of Autologous T Cells

    Mitogenic Properties of Allogeneic Helper Factors

    Generation of Helper Factors in Autologous Mixed Lymphocyte Reactions

    Effects of Anti-Immunoglobulins and MLR-Derived Helper Factors on Human B Cell Differentiation

    Summary

    References

    Heteroantibodies to Human T Cell Tumors: Recognition of Normal and Malignant T Cell Subsets

    Introduction

    Preparation and Characterization of Anti-Human Lymphoma Sera

    Functional Analysis of Normal T Cell Subsets Bearing Od Determinants

    Functional Characterization of Human T Cell Lymphomas

    Summary

    References

    T Cell Helper Factors in Man

    Introduction

    Lymphocyte Mitogenic Factor

    Human Antigen-Specific T Cell Helper Factor (ASF)

    Conclusions

    References

    Regulatory Interactions of Human T Cells

    Characteristics of TM and TG Cells

    Helper and Suppressor Control of B Cell Responses

    Mechanism by Which TG Cells Suppress B Cell Differentiation

    Lineal Relationship of TM and TG Cells

    T Cell Malignancies

    Alteration of Circulating TM and TG Cells in Immunological Disorders

    References

    Part V Suppressor T Cells (Murine)

    The Appearance of 460-Idiotype (460-Id )-Bearing Anti-TNP Antibodies Is Regulated by Suppressor T Cells Specific for 460-Id

    Expression of the 460-Id by Anti-TNP Antibodies

    T Cell Regulation of the 460-Id 10; Component of the Anti-TNP-PFC Response to TNP-NWSM

    Specificity of Suppressor T Cells

    Phenotype and Site of Action of 460-Id-Specific Suppressor T Cells

    Relationship between Occurrence of 460-Id-Specific Suppressor T Cells and IgCHα Allotype

    Enhancement of the 460-Id+ Component of the Anti-TNP Response by Anti-(Anti-460-Id) Anti-Idiotype Antibodies

    Conclusions

    References

    Regulatory T Cell Subsets: Functions in Responses to an Antigen Under Ir Gene Control

    Introduction

    Experimental System

    Regulatory T Cell Subsets Generated by Immunization with Syngeneic and

    Allogeneic Gat-Macrophages

    Regulatory T Cell Subsets in Spleen Cells from (Responder x Nonresponder) F1 Mice

    Discussion

    References

    Induction of Allotype Suppression with Monoclonal Antibodies

    Introduction

    Results

    Discussion

    References

    MHC Restriction and Positive Selection of T Suppressor Cells Revealed by Mixture with Inducer T Cells

    Introduction

    Materials and Methods

    Results

    Discussion

    Summary

    References

    Part VI Suppressor T Cells (Human)

    Characterization of Regulatory T Cells in Man

    Introduction

    T Cell Subsets in Man

    Summary: A Network of T Cell Subsets

    References

    Suppressor Cell Populations in Normal and Immunodeficient Humans

    Introduction

    Methods

    Results and Discussion

    Conclusions

    References

    Disorders of Suppressor T Cells in Immunodeficiency and Malignancy

    In Vitro Methods Used for the Study of Human Helper and Suppressor Activity

    Leukemias of the T Cell System That Retain Immunoregulatory Functions

    T Cell Neoplasms Which May Retain Helper Activity

    Neoplasms of Cells of the Suppressor T Cell Network

    T Suppressor Cells in the Bursectomized Bird Model of Agammaglobulinemia

    Disorders of Suppressor T Cells Associated with Primary Immunodeficiency Diseases

    Implications for Immunoprophylaxis and Immunotherapy

    Summary

    References

    Part VII Regulatory T Cell Circuits

    The Generation of Effector Functions as a Result of Communication Between Subclasses of T Lymphocytes

    Introduction

    Lymphocyte Subpopulations Participating in the Generation of Cytotoxic T Cells

    Suppression of T Helper Cells But Not of B Cells by Idiotype-Specific Suppressor T Cells

    Recognition of Idiotype as a Means for Lymphocytes to Communicate

    Conclusions

    References

    Regulatory Circuits and Affinity Maturation

    Introduction

    The Core Regulatory Circuit (CRC)

    Auxiliary Regulatory Circuits

    Helper T Cells in the ARC's

    ARC Control of Affinity Maturation

    Applying the Circuit Model to Reality

    Memory B Cell Development and Affinity Maturation

    References

    Index




Product details

  • No. of pages: 472
  • Language: English
  • Copyright: © Academic Press 1980
  • Published: January 1, 1980
  • Imprint: Academic Press
  • eBook ISBN: 9780323149099

About the Editor

Benvenuto Pernis

Ratings and Reviews

Write a review

There are currently no reviews for "Regulatory T Lymphocytes"