Regulatory T Cells in Health and Disease

Regulatory T Cells in Health and Disease

1st Edition - November 24, 2015
  • Editor: Adrian Liston
  • Hardcover ISBN: 9780128034156
  • eBook ISBN: 9780128034194

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Description

Regulatory T Cells in Health and Disease focuses on the mechanism by which T cells become regulatory T cells, the processes which control the number of regulatory T cells in the blood and tissue, and the ways in which regulatory T cell prevent autoimmune disease and interact with infections and cancer.

Key Features

  • Contains contributions from leading authorities in the field of regulatory T cell biology
  • Informs and updates on all the latest developments in the field
  • Explores the processes which control the number of regulatory T cells in the blood and tissue, and the ways in which regulatory T cell prevent autoimmune disease and interact with infections and cancer

Readership

Medical researchers

Table of Contents

    • Preface
    • Chapter One: Transcriptional and Epigenetic Control of Regulatory T Cell Development
      • Abstract
      • 1 Introduction
      • 2 Transcriptional Regulation in Treg Cells
      • 3 Epigenetic Regulation in Treg Cells
      • 4 Cross talk Between Foxp3-Dependent Gene Regulation and Treg Cell-Type Epigenetic Modifications
      • 5 Treg Cell Development
      • 6 Conclusion
      • Acknowledgment
    • Chapter Two: Microenvironment Matters: Unique Conditions Within Gut-Draining Lymph Nodes Favor Efficient De Novo Induction of Regulatory T Cells
      • Abstract
      • 1 Introduction: Key Treg Characteristics
      • 2 Peripheral De Novo Induction of Foxp3+ Tregs Within the Gastrointestinal Immune System
      • 3 Outlook
    • Chapter Three: Understanding the Roles of the NF-κB Pathway in Regulatory T Cell Development, Differentiation and Function
      • Abstract
      • 1 Introduction
      • 2 NF-κB and Treg Development
      • 3 NF-κB Involvement in Treg Function
      • 4 Conclusion
    • Chapter Four: The Molecular Control of Regulatory T Cell Induction
      • Abstract
      • 1 Introduction
      • 2 Treg Differentiation in the Thymus
      • 3 Peripheral Treg
      • 4 Concluding Remarks
      • Acknowledgments
    • Chapter Five: The Special Relationship in the Development and Function of T Helper 17 and Regulatory T Cells
      • Abstract
      • 1 T Helper 17 Cells
      • 2 Th17 Cells and Treg Cells: A Special Relationship
      • 3 Concluding Remarks
      • Acknowledgments
    • Chapter Six: Mechanisms of Surveillance of Dendritic Cells by Regulatory T Lymphocytes
      • Abstract
      • 1 Of Mice and Men: An Historical Perspective on Tregs
      • 2 Immunosuppressive Mechanisms of Tregs
      • 3 Tregs Impair DC Function
      • 4 Concluding Remarks
    • Chapter Seven: Development and Function of Effector Regulatory T Cells
      • Abstract
      • 1 Introduction
      • 2 Features of Effector T Regulatory Cells
      • 3 Role of TCR Signaling in Effector T Regulatory Cell Differentiation
      • 4 Cytokine Requirements of Effector T Regulatory Cells
      • 5 Distinct Migratory Properties of Effector T Regulatory Cells
      • 6 Functional Specialization of Effector T Regulatory Cells
      • 7 Effector T Regulatory Cells in Nonlymphoid Organs
      • 8 A Unified Model of Effector T Regulatory Cell Differentiation
      • 9 Future Perspectives
      • Acknowledgments
    • Chapter Eight: Treg Cell Differentiation: From Thymus to Peripheral Tissue
      • Abstract
      • 1 Introduction
      • 2 Thymic Treg Cells
      • 3 Further Differentiation of Treg Cells in the Periphery
      • 4 Future Perspectives
      • Acknowledgments
    • Chapter Nine: Regulatory T cells in Arthritis
      • Abstract
      • 1 Introduction
      • 2 Treg Cells in the Inflammation That Occurs in RA
      • 3 Treg Cells in the Bone Destruction in RA
      • 4 The Plasticity of Foxp3+ T Cell in Arthritis
      • 5 Treg Cell-Targeted Therapies Against RA
      • 6 Conclusions
      • Acknowledgment
    • Chapter Ten: The Immune Fulcrum: Regulatory T Cells Tip the Balance Between Pro- and Anti-inflammatory Outcomes upon Infection
      • Abstract
      • 1 Introduction
      • 2 Acute Infections in Delicate Tissues
      • 3 Acute Systemic Viral Infections
      • 4 Gastrointestinal Infections
      • 5 Chronic Infections
      • 6 Conclusions and Future Directions
    • Chapter Eleven: Regulatory T Cells in Autoimmune Diabetes: Mechanisms of Action and Translational Potential
      • Abstract
      • 1 Introduction
      • 2 Sites of Treg Action in T1D
      • 3 Mechanisms of Treg Suppression in T1D
      • 4 Therapeutic Manipulation of Treg in T1D
      • 5 Concluding Remarks
      • Acknowledgments

Product details

  • No. of pages: 300
  • Language: English
  • Copyright: © Academic Press 2015
  • Published: November 24, 2015
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128034156
  • eBook ISBN: 9780128034194

About the Serial Volume Editor

Adrian Liston

Adrian Liston
Adrian Liston is Professor in Autoimmune Genetics at the University of Leuven and the VIB, Belgium. His PhD research was on T cell tolerance and diabetes with Professor Chris Goodnow at the Australian National University, followed by post-doctoral research on regulatory T cell biology with Professor Sasha Rudensky at the University of Washington. The Liston laboratory is supported by an ERC Start Grant, a JDRF Career Development Award, a VIB Investigators Award and grants from the FWO and KUL. Adrian Liston has published more than 70 papers, with over 3000 citations, including key publications on the function of Aire in thymic tolerance, defective tolerance in the NOD mouse, the contribution of immunodeficiency to autoimmunity, microRNA function in regulatory T cells, the discovery of the follicular regulatory T cell, the role of microRNA in the thymic epithelium and the homeostatic control over regulatory T cells.

Affiliations and Expertise

Katholieke Universiteit Leuven, Belgium