Regulatory Aspects of Carcinogenesis and Food Additives: The Delaney Clause

Regulatory Aspects of Carcinogenesis and Food Additives: The Delaney Clause

1st Edition - January 1, 1979

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  • Editor: Frederick Coulston
  • eBook ISBN: 9780323151016

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Regulatory Aspects of Carcinogenesis and Food Additives: The Delaney Clause is composed of papers and discussions presented in the seventh meeting of the International Academy of Environmental Safety regarding the philosophy of the Delaney Clause. The Delaney Clause became a part of the Food and Drug Law in 1958. It states in part “that no additive shall be deemed to be safe if it is found to induce cancer when ingested by man or animal, or if it is found after tests which are appropriate for evaluation of safety of food additives to induce cancer in man or animal”. This book covers the different views of the meeting’s participants on the interpretation of the Delaney Clause. It presents list of points that should be considered in making decisions with respect to safety. Many other factors that should be taken into consideration are also discussed in this reference.

Table of Contents

  • Participants ix


    Session I

    Public Policy Issues in Regulating Carcinogens in Food

    The Delaney Clause: An Experimental Policy Decision That Has Been Misinterpreted

    The Regulation of Carcinogens at The Environmental Protection Agency

    By Appropriate Methods: The Delaney Clause

    Alternatives to Be Considered in Benefit: Risk Decision-Making

    Decision-Making Issues Relevant to Cancer-Inducing Substances

    Session II

    The Delaney Clause: An Idea Whose Time Has Come for a Change

    The Predictive Value of Animal Tests for Carcinogenicity

    The Design Criteria and Application of Dose-Response Relationships to Interpretation of Carcinogenesis Bioassay

    The Role of the Endoplasmic Reticulum in Carcinogenesis

    Chemically Induced Tumors: Their Relationship to Human Cancer

    Metabolism and Photodegradation of Chlorinated Hydrocarbons and Their Potential in Carcinogenesis

    Experimental Procedures in the Evaluation of Chemical Carcinogens

    Negative Health Implications of the Delaney Philosophy

    The Use Of Nonhuman Primates for Chemical Carcinogenesis Studies

    Session III

    Extrapolating Animal Risk to Humans

    Assessments at an International Level of Health Hazards to Man of Chemicals Shown to Be Carcinogenic in Laboratory Animals

    The Establishment of European Community Legislation for Toxic Substances

    Impact of the Delaney Clause on the Research-Intensive Manufacturer of Biomedical Products

    Impact of the Delaney Clause Philosophy on the Chemical Industry

    The Delaney Clause: Relation to the Development of Chemical Carcinogenesis

    Concluding Discussion



Product details

  • No. of pages: 423
  • Language: English
  • Copyright: © Academic Press 1979
  • Published: January 1, 1979
  • Imprint: Academic Press
  • eBook ISBN: 9780323151016

About the Editor

Frederick Coulston

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