Regulation of Ventilation and Gas Exchange - 1st Edition - ISBN: 9780122046506, 9780323156004

Regulation of Ventilation and Gas Exchange

1st Edition

Editors: Donald Davies
eBook ISBN: 9780323156004
Imprint: Academic Press
Published Date: 1st January 1978
Page Count: 320
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Description

Regulation of Ventilation and Gas Exchange is a comprehensive account of the regulation of ventilation and gas exchange. Topics covered include central nervous system regulation of ventilation; ventilatory response to muscular exercise; respiratory control in air-breathing ectotherms; and breathing during sleep. Hydrogen ion homeostasis of the cerebral extracellular fluid is also discussed, along with specific mechanisms for O2 and CO transport in the lung and placenta.

Comprised of nine chapters, this book begins with an overview of the neural elements that modify and/or are intrinsic to the respiratory rhythm. The next two chapters deal with the contribution of metabolic factors in the control of ventilation, paying particular attention to the importance of metabolic factors during muscular exercise and the specific role of ammonia in the regulation of respiration. A view of ventilatory control from a comparative standpoint, stressing both adaptive and mechanistic phenomena, is then presented. Subsequent chapters explore the regulation of breathing during sleep; regulation of cerebral extracellular fluid acid-base composition and its role in the control of ventilation and cerebral blood flow; carrier-mediated transport of respiratory gases; and measurement of ventilation-perfusion ratios is presented. The last chapter considers lung surfactant mechanics and addresses issues such as in vitro vs in situ measurements of surface tension and the effects of surface tension on pulmonary vascular resistance and interstitial pressure.

This monograph is designed not only for respiratory physiologists but also for students and researchers in other areas with an inclination toward respiratory physiology.

Table of Contents


List of Contributors


Preface


Chapter 1 Central Nervous System Regulation of Ventilation


I. Introduction


II. Brainstem Respiratory Centers


III. Nervous System Integration of Chemoreceptor Stimuli


IV. Summary


V. Afterword: The "Problem of Anesthesia"


References


Chapter 2 Ventilatory Response to Muscular Exercise


I. Introduction


II. Moderate Exercise


III. Interaction of Moderate Exercise with Other Ventilatory Stimuli


IV. Severe Exercise


V. Summary and Conclusions


References


Chapter 3 Ammonia and the Regulation of Ventilation


I. Introduction


II. Metabolic Effects of Ammonia


III. Source of Ammonia


IV. Effect of Ammonia on Control of Ventilation in the Dog


V. Summary


References


Chapter 4 Respiratory Control in Air-Breathing Ectotherms


I. Introduction


II. Respiratory Adaptations of Vertebrates


III. Bases of Respiratory Control


IV. Temperature and Respiratory Control


V. Conclusions


References


Chapter 5 Breathing during Sleep


I. Introduction


II. Definition of Sleep and Wakefulness


III. A Description of Breathing during Sleep


IV. Respiratory Reflexes during Sleep


V. Upper Airway Function during Sleep and Wakefulness


VI. Neurophysiological Interpretations


VII. Summary


References


Chapter 6 Hydrogen Ion Homeostasis of the Cerebral Extracellular Fluid


I. Introduction


II. Regulation of CSF PCO2


III. Regulation of CSF Bicarbonate Concentration


Iv. Cerebral ECF Acidity and the Regulation of Cerebral Blood Flow and Ventila

Details

No. of pages:
320
Language:
English
Copyright:
© Academic Press 1978
Published:
Imprint:
Academic Press
eBook ISBN:
9780323156004

About the Editor

Donald Davies

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