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Regenerative Nephrology - 2nd Edition - ISBN: 9780128233184

Regenerative Nephrology

2nd Edition

Editor: Michael Goligorsky
Hardcover ISBN: 9780128233184
Imprint: Academic Press
Published Date: 1st June 2021
Page Count: 442
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Description

Since the publication of the first edition of this book in 2010, an explosion of spectacular discoveries in the field of regeneration has compelled the current revisit of the field of Regenerative Nephrology. This second edition features subjects as diverse as age and gender influencing regenerative processes; mechanisms and pathways of premature cell senescence affecting kidney regeneration; the ways intrinsic regenerative processes can become subverted by noxious stressors eventuating in disease progression; novel mechanistic and engineering efforts to recreate functional kidney or its component parts; cell reprogramming and reconditioning as emerging tools of future regenerative efforts; and effects of various biologicals on kidney regeneration. These newer additions to the armamentarium of Regenerative Medicine and Nephrology have become an integral part of the second edition of the book. Cutting-edge investigations are summarized by the constellation of the most experienced contributing authors coming together from around the world under the umbrella of the second edition.

Key Features

  • A significant expansion of section on induced pluripotent cells and trajectories of their differentiation. This will be followed by mechanisms and modalities of cell reprogramming for therapeutic purposes
  • A new section on tissue engineering of the kidney of interest to nephrologists and urologists
  • An entire section dedicated to causes of regenerative failure with the emphasis on recent discoveries of senescent cells in kidney disease, pathologic effects of senescent cells, advents in senotherapies and rejuvenation therapies
  • A vastly expanded section on pharmacotherapies promoting kidney regeneration, trials of engineered organs, manufacturing in regenerative medicine and smooth transition to the clinical trials, with an update on some ethical issues

Readership

Experimental and clinical nephrologists, stem cell specialists, molecular and developmental biologists, biomedical engineers, pharmacologists and physiologists

Table of Contents

Section I: PHYLOGENY AND ONTOGENY OF TISSUE REGENERATION
1. Glomerulogenesis and de novo nephrogenesis in medaka fish - evolutionary approach
Yuko Wakamatsu and Hisashi Hashimoto
2. Renal Organogenesis: Growing a replacement kidney in situ from transplanted renal primordia
Marc R. Hammerman
3. Use of Genetic Mouse Models to study Kidney Regeneration
Akio Kobayashi and Jeremy S. Duffield

Section: II MEDIATORS OF REGENERATION
4. Endogenous Anti-Inflammatory and Pro-Resolving Lipid Mediators in Renal Disease
Charles N. Serhan and Catherine Godson
5. Tissue protection and regeneration aided by erythropoietin and erythropoietin-derived peptides
Danilo Fliser
6. Mast cells in kidney regeneration
Eric Daugas, Walid Beghdadi and Ulrich Blank
7. Role of macrophages in renal injury, repair and regeneration
Vincent Lee, Qi Cao, Yiping Wang and David C.H. Harris
8. T-cells contribution to regenerative processes
Hamid Rabb

Section: III STEM CELLS IN REGENERATIVE PROCESSES
9. MSC and reparative processes
Benjamin D. Humphreys and John V. Bonventre
10. Stem cells in regenerative processes: Endothelial progenitor cells and the kidney
Matthieu Monge, Anton J. van Zonneveld and Ton J. Rabelink
11. The potential of the side population in regenerative nephrology
Melissa H. Little and G. A. Challen
12. Very small embryonic like stem cells (VSELs) and their potential relevance for kidney homeostasis
Dong-Myung Shin, Rui Liu, Janina Ratajczak, Magda Kucia and Mariusz Z. Ratajczak
13. Stem Cells in Regenerative Processes; Induced Pluripotent Stem Cells
Kenji Osafune and Shinya Yamanaka
14. Methods of Isolation and Culture of Adult Stem cells
Lindolfo da Silva Meirelles and Nance Beyer Nardi

Section: IV STEM CELLS - FROM THE NICHE TO REPAIR
15. Stem cell niche in the kidney
Laura Lasagni, Elena Lazzeri and Paola Romagnani
16. Creation of artificial niches
Glenn D. Prestwich, Tammer Ghaly, Philip Brudnicki, Brian Ratliff and Michael S. Goligorsky
17. Imaging of transplanted and native stem cells
Xiang-Yang Zhu, Martin Rodriguez-Porcel and Lilach O. Lerman

Section V: CAUSES OF REGENERATIVE FAILURE
16. Stem cell injury and premature senescence
Michael S. Goligorsky
17. Regeneration and Aging: Regulation by Sirtuins and the NAD+ Salvage Pathway
Nica M. Borradaile, Alanna Watson, and J. Geoffrey Pickering
18. Bone marrow-mesenchymal stem cells in organ repair and strategies to optimize their efficacy
Christodoulos Xinaris, Barbara Imberti, Giuseppe Remuzzi and Marina Morigi

Section VI: EMERGING CLINICAL ASPECTS OF STEM CELL THERAPY
19. Treatment of Acute Kidney Injury with allogeneic Mesenchymal Stem Cells: Preclinical and initial Clinical Data
Florian E. Tögel and Christof Westenfelder
20. Clinical trials in Renal Regenerative Medicine
Maarten B. Rookmaaker, Jaap A. Joles and Marianne C. Verhaar
21. Potential risks of stem cell therapies
Uta Kunter and Jürgen Floege
22. Tissue engineering in urology
Anthony Atala
23. Ethical issues in SC therapy
Donald W. Landry
24. Stem Cell Banking
Vicente Mirabet and Pilar Solves

Details

No. of pages:
442
Language:
English
Copyright:
© Academic Press 2021
Published:
1st June 2021
Imprint:
Academic Press
Hardcover ISBN:
9780128233184

About the Editor

Michael Goligorsky

Michael S. Goligorsky, MD. PhD, holds the Alvin I. Goodman Chair in Nephrology, and is Professor of Medicine, Pharmacology and Physiology and Director of Renal Research Institute at the New York Medical College, Touro University. Dr. Goligorsky serves as an Associate Editor for Am J Pathology and is a member of the Association of American Physicians (elected 2002). His research interests include: the mechanisms of endothelial dysfunction as a harbinger of diabetic, and hypertensive vascular damage; stress-induced premature senescence of endothelial cells and the role of lysosomal dysfunction in this process; mechanisms of functional incompetence of endothelial cells in chronic kidney disease; and mechanisms of alarm signaling by an ischemic kidney.

Affiliations and Expertise

Alvin I. Goodman Chair in Nephrology, Professor of Medicine, Pharmacology and Physiology, Academic Chief of Renal Division, and Director of Renal Research Institute, New York Medical College, NY, USA

Ratings and Reviews