Regenerative Nephrology

Regenerative Nephrology

2nd Edition - June 12, 2021

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  • Editor: Michael Goligorsky
  • Hardcover ISBN: 9780128233184
  • eBook ISBN: 9780128233191

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Since the publication of the first edition of this book in 2010, an explosion of spectacular discoveries in the field of regeneration has compelled the current revisit of the field of Regenerative Nephrology. This second edition features subjects as diverse as age and gender influencing regenerative processes; mechanisms and pathways of premature cell senescence affecting kidney regeneration; the ways intrinsic regenerative processes can become subverted by noxious stressors eventuating in disease progression; novel mechanistic and engineering efforts to recreate functional kidney or its component parts; cell reprogramming and reconditioning as emerging tools of future regenerative efforts; and effects of various biologicals on kidney regeneration. These newer additions to the armamentarium of Regenerative Medicine and Nephrology have become an integral part of the second edition of the book. Cutting-edge investigations are summarized by the constellation of the most experienced contributing authors coming together from around the world under the umbrella of the second edition.

Key Features

  • A significant expansion of section on induced pluripotent cells and trajectories of their differentiation. This will be followed by mechanisms and modalities of cell reprogramming for therapeutic purposes
  • A new section on tissue engineering of the kidney of interest to nephrologists and urologists
  • An entire section dedicated to causes of regenerative failure with the emphasis on recent discoveries of senescent cells in kidney disease, pathologic effects of senescent cells, advents in senotherapies and rejuvenation therapies
  • A vastly expanded section on pharmacotherapies promoting kidney regeneration, trials of engineered organs, manufacturing in regenerative medicine and smooth transition to the clinical trials, with an update on some ethical issues


Experimental and clinical nephrologists, stem cell specialists, molecular and developmental biologists, biomedical engineers, pharmacologists and physiologists

Table of Contents

  • Section 1: Kidney Development and Regeneration

    1. Nephrogenesis in Health and Disease

    Adrian S. Woolf and Sophie L. Ashley

    2. Renal organogenesis in the lymph node microenvironment

    Maria Giovanna Francipane

    3. In vivo clonal analysis and the kidney: Implications to regenerative nephrology

    Oren Pleniceanu Benjamin Dekel

    4. Nephrogenesis in malnutrition

    Brian B. Ratliff, May M. Rabadi, and Selin Celikoyar

    Section 2: Modulators of Regeneration

    5. Endogenous anti-inflammatory and pro-resolving lipid mediators in renal disease

    Ross Doyle and Catherine Godson

    6. T-cell in kidney injury and regeneration

    Li Li, Dylan Baer, and Mark D. Okusa

    7. Monocytes and dendritic cells in injury and regeneration

    Elise N. Erman, Meryl C. Nath, Matthew D. Cheung, Anupam Agarwal, and James F. George

    8. Mast cells in kidney regeneration

    Eric Douglas, Nicholas Charles, and Ulrich Blank

    Section 3: Stem Cells in Regenerative Processes

    9.Regeneration and replacement of endothelial cells and renal vascular repair

    David P. Basile and Mervin C. Yoder

    10. Stem cells in regenerative processes: Induced pluripotent stem cells

    Kenji Osafune

    11. Nephroprotective effect of urine-derived stem cells for renal injury

    Yuanyuan Zhange and Anthony Atala

    12. Amniotic stem cells and their exosomes

    Jing Ji and Li Yang

    13. Regenerative potential of stem-cell-derived extracellular vesicles

    Hoon Young Choi and Hyeong Cheon Park

    14. Stem cell therapies in diabetes

    Sevim Kahraman, Danielle Diegisser, and Ercument Dirice

    Section 4: Causes of Regenerative Failure

    15. Progression of kidney disease as a maladaptive response to injury

    Xuezhu Li, Fend Ding, Kyung Lee, and John Cijiang He

    16. Molecular mechanisms of cellular senescence

    Jamil Nehme, Marta Varela-Eirin, and Marco Demaria

    17. Characteristics of senescent cells

    Roland Schmitt and Anette Melk

    18. Stress-induced senescence of tubular cells

    David P. Baird, David A. Ferenbach, and Joseph V. Bonventre

    19. Stress-induced senescence as a forme fruste of chronic kidney disease- A case for failed regeneration

    Michael S. Goligorsky

    20. Premature vascular aging and senescence in chronic kidney disease

    Thomas Ebert and Peter Stenvinkel

    21. Injury and regeneration in renal aging

    Janka Babickova, Hai-Chun Yang, and Agnes B. Fogo

    22. Gender-dependent mechanisms of injury and repair

    Joel Neugarten and Ladan Golestaneh

    Section 5: Kidney Engineering

    23. Glomerular stem cells

    Laura Lasagni, Benedetta Mazzinghi, and Paola Romagnani

    24. Reconstitution of the kidney glomerular capillary wall

    Titilola D. Kalejaiye, Jordan A. Holmes, Rohan Bhattacharya, and Samira Musah

    25. Microfluidic modeling of glomerulus and tubular appartus

    Gretchen J. Mahler and Stephanie Zhang

    26. Matrix scaffolds in kidney engineering

    Sean Muir, Catherine La Pointe, Domenica Ida Marino, Amish Asthana, and Guiseppe Orlando

    Section 6: Emerging Clinical Aspects of Regenerative Therapy

    27. Reprogramming toward kidney regeneration: New technologies and future promises

    Yun Xia and Juan Carlos Izpisua Belmonte

    28. Therapy cell reconditioning

    Michael S. Goligorsky

    29. Senomorphic, senolytic, and rejuvenation therapies

    Xiang Yang Zhu and Lilach O. Lerman

    30. Natural products in regeneration
    Rachel B. Wilson, Jason J. Lee, Geoffrey Pickering, and Nica M. Borradaile 

    31. Nanotargeting to the kidney

    Ryan M. Williams, Chintan Kapadia, Edgar A. Jaimes, and Daniel A. Heller

    32. Small molecules in regeneration

    Amanda E. Crunk, Aneta Przepiorski, and Neil Hukriede

    33. Systems biology in diagnosis and reamtnet of kidney disease

    Jennifer Schaub and Matthias Kretzler

    34. Overview of ethical concerns raised by kidney organoids

    Paola Nicolas and Ira Bedzow

    35. Manufacturing challenges and solutions for tissue engineering and regenerative medicine technologies

    Joshua Hunsberger and Sita Somara

Product details

  • No. of pages: 528
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: June 12, 2021
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128233184
  • eBook ISBN: 9780128233191

About the Editor

Michael Goligorsky

Michael S. Goligorsky, MD. PhD, holds the Alvin I. Goodman Chair in Nephrology, and is Professor of Medicine, Pharmacology and Physiology and Director of Renal Research Institute at the New York Medical College, Touro University. Dr. Goligorsky serves as an Associate Editor for Am J Pathology and is a member of the Association of American Physicians (elected 2002). His research interests include: the mechanisms of endothelial dysfunction as a harbinger of diabetic, and hypertensive vascular damage; stress-induced premature senescence of endothelial cells and the role of lysosomal dysfunction in this process; mechanisms of functional incompetence of endothelial cells in chronic kidney disease; and mechanisms of alarm signaling by an ischemic kidney.

Affiliations and Expertise

Alvin I. Goodman Chair in Nephrology, Professor of Medicine, Pharmacology and Physiology, Academic Chief of Renal Division, and Director of Renal Research Institute, New York Medical College, NY, USA

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