Regenerative Medicine Applications in Organ Transplantation

1st Edition

Editors: Giuseppe Orlando
Hardcover ISBN: 9780123985231
eBook ISBN: 9780123985200
Imprint: Academic Press
Published Date: 5th November 2013
Page Count: 1050
Tax/VAT will be calculated at check-out
Compatible Not compatible
VitalSource PC, Mac, iPhone & iPad Amazon Kindle eReader
ePub & PDF Apple & PC desktop. Mobile devices (Apple & Android) Amazon Kindle eReader
Mobi Amazon Kindle eReader Anything else

Institutional Access


Regenerative Medicine Applications in Organ Transplantation illustrates exactly how these two fields are coming together and can benefit one another. It discusses technologies being developed, methods being implemented, and which of these are the most promising. The text encompasses tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, all from a transplant perspective. Organ systems considered include liver, renal, intestinal, pancreatic, and more. Leaders from both fields have contributed chapters, clearly illustrating that regenerative medicine and solid organ transplantation speak the same language and that both aim for similar medical outcomes. The overall theme of the book is to provide insight into the synergy between organ transplantation and regenerative medicine.

Recent groundbreaking achievements in regenerative medicine have received unprecedented coverage by the media, fueling interest and enthusiasm in transplant clinicians and researchers. Regenerative medicine is changing the premise of solid organ transplantation, requiring transplantation investigators to become familiar with regenerative medicine investigations that can be extremely relevant to their work. Similarly, regenerative medicine investigators need to be aware of the needs of the transplant field to bring these two fields together for greater results.

Key Features

  • Bridges the gap between regenerative medicine and solid organ transplantation and highlights reasons for collaboration
  • Explains the importance and future potential of regenerative medicine to the transplant community
  • Illustrates to regenerative medicine investigators the needs of the transplant discipline to drive and guide investigations in the most promising directions


Basic and clinical researchers in the fields of regenerative medicine, transplantation, tissue engineering, biomaterial sciences, stem cell biology, developmental biology, and related fields

Table of Contents


Meet the Editors

List of Contributors

Preface: Solid Organ Transplantation in the Regenerative Medicine Era

Chapter 1. Introduction: Regenerative Medicine and Solid Organ Transplantation from a Historical Perspective

1.1 Introduction

1.2 Major Advances in Organ Transplantation

1.3 Regenerative Medicine


Chapter 2. Solid Organ Transplantation: Has the Promise Been Kept and the Needs Met?

2.1 Introduction

2.2 Tolerance in organ transplantation

2.3 Organ shortage

2.4 Conclusions


Part I: Principles of Regenerative Medicine and Cell, Tissue, and Organ Bioengineering

Chapter 3. Strategies for the Specification of Tissue Engineering Biomaterials

3.1 Introduction: the Engineering Approach to Tissue Regeneration

3.2 Principles of Biomaterials Selection in Tissue Engineering

3.3 Specific Types of Template Material

3.4 Concluding Comments

Author’s Note


Chapter 4. Principles of Stem Cell Biology

4.1 The Origin of the Cell Reprogramming

4.2 Somatic Cell Nuclear Transfer

4.3 Cell Fusion

4.4 Transcription Factor Transduction: iPS Cell Generation

4.5 Novelty in Nuclear Reprogramming

4.6 Comparison Between the Three Approaches of Nuclear Reprogramming

4.7 Conclusions


Chapter 5. Principles of Cell Sheet Technology

5.1 Introduction

5.2 Functional Tissue Regeneration Using Cell Sheets

5.3 Conclusions



Chapter 6. Principles of Bioprinting Technology

6.1 Introduction

6.2 Bio-blueprint

6.3 Bio-ink

6.4 Bio-Paper

6.5 Organ Bio-Printers and Bioprinting Methods

6.6 Summary



Chapter 7. Synthetic Biomaterials for


No. of pages:
© Academic Press 2014
Academic Press
eBook ISBN:
Hardcover ISBN:

About the Editor

Giuseppe Orlando

Transplant surgeon scientist, specializing in kidney and pancreas transplantation, as well as in abdominal organ bioengineering and regeneration. My main achievements have been in the field of steroid-free immunosuppression (IS), IS minimization and clinical tolerance after liver transplantation, as well as in the development of platforms for renal, small bowel and endocrine pancreas bioengineering and regeneration research. The main goal of my investigations is to bio-engineer and implant in humans renal organoids, insulin-producing cells and segments of small bowel. The ability to produce kidneys, insulin-producing cells and small bowel from patient’s own cells will revolutionize transplant medicine. The main goal of my scientific production is to orchestrate the transition of organ transplantation towards a regenerative medicine-focused type of research. I originally hail from Rome, Italy, where I grew up, matriculated, attended medical school, and received training in general and transplant surgery. I also participated in fellowships in Paris (Liver Unit, Paul Brousse Hospital, Dir: Henri Bismuth, 6 months) and Brussels (General and Transplant Surgery, Catholic University of Leuven, Dir: Jan Lerut, Jean Bernard Otte, Jean De Ville De Goyet, 31 months). 2006-2008, I was a practicing transplant surgeon at the University of L'Aquila, Italy. 2008-2011, I received and implemented the distinguished Marie Curie International Outgoing Fellowship, for which I spent 2 years at the Wake Forest Institute of Regenerative Medicine (Winston Salem, USA) and 1 year at the Transplant Research Immunology Group (Oxford, UK), specializing in organ bioengineering and regeneration and transplant immunology. I have authored more than 135 research papers, review articles, and book chapters. I have just published – as editor in chief – a book on organ transplantation and regenerative medicine which is destined to set a new standard in transplant and regenerative medicine literature and

Affiliations and Expertise

Marie Curie Fellow, Assistant Professor of Surgery, Department of General Surgery, Section of Transplantation, Wake Forest Baptist Health Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA


"It is without doubt a very valuable book that captures well the current status of the many areas it addresses...It is a superb summary of the current status of RM and organ transplantation."--Expert Review of Clinical Immunology, Regenerative Medicine Applications in Organ Transplantation

"…represents an invaluable reference for students, physicians, and researchers who are interested in getting a comprehensive, up-to-date snapshot on how regenerative medicine and organ transplantation are reshaping the medical profession."--Transplantation,November 27,2014

"…an invaluable reference for students, physicians, and researchers who are interested in getting a comprehensive up-to-date snapshot on how regenerative medicine and organ transplantation are reshaping the medical profession."--Transplantation, Nov 27 2014

"Given the implications that a chronic shortage of organs has on public health and society, this book is a valuable resource for students and professionals seeking to do something about this problem by taking advantage of cutting-edge developments in one of those most dynamic scientific disciplines existing today, namely regenerative medicine."--Regenerative Medicine 2014 9(3)
"The text is well organized…Chapters on tracheal reconstruction and bladder reconstruction are impressive in demonstrating proximity to clinical utility and indicate that simple structural elements can be manufactured and implanted in humans to bridge a limited defect…if you want to spark your enthusiasm for what is to come, then this textbook is a fine first step into the future."--American Journal of Transplantation, June 2014
"With beautiful illustrations throughout that greatly enhance the overall reading experience of this book, this book is a must-have for anyone i