Regenerative Biology and Medicine

2nd Edition

Authors: David Stocum
Paperback ISBN: 9780123848604
eBook ISBN: 9780123848611
Imprint: Academic Press
Published Date: 31st May 2012
Page Count: 474
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Regenerative Biology and Medicine, Second Edition — Winner of a 2013 Highly Commended BMA Medical Book Award for Medicine — discusses the fundamentals of regenerative biology and medicine. It provides a comprehensive overview, which integrates old and new data into an ever-clearer global picture. The book is organized into three parts. Part I discusses the mechanisms and the basic biology of regeneration, while Part II deals with the strategies of regenerative medicine developed for restoring tissue, organ, and appendage structures. Part III reflects on the achievements of regenerative biology and medicine; future challenges; bioethical issues that need to be addressed; and the most promising developments in regenerative medicine. The book is designed for multiple audiences: undergraduate students, graduate students, medical students and postdoctoral fellows, and research investigators interested in an overall synthesis of this field. It will also appeal to investigators from fields not directly related to regenerative biology and medicine, such as chemistry, informatics, computer science, mathematics, physics, and engineering.

Key Features

  • Highly Commended 2013 BMA Medical Book Award for Medicine
  • Includes coverage of skin, hair, teeth, cornea, and central neural tissues
  • Provides description of regenetive medicine in digestive, respiratory, urogenital, musculoskeletal, and cardiovascular systems
  • Includes amphibians as powerful research models with discussion of appendage regeneration in amphibians and mammals


Researchers and students in biology, chemistry, and bioengineering; medical students; academic and clinical physicians; and research investigators

Table of Contents

Preface Part I Regenerative Biology

1. An Overview of Regenerative Biology I. Introduction II. A Brief History of Regenerative Biology III. Regeneration Occurs at All Levels of Biological Organization IV. Mechanisms of Vertebrate Regeneration V. The Niche Concept in Tissue Repair VI. Approaches to the Study of Regeneration Summary References 2. Repair of Skin by Fibrosis I. Introduction II. Structure of Adult Mammalian Skin III. Phases of Repair By Fibrosis IV. Tattoos and Fetal Skin Have a Minimal Immune Response to Wounding V. Comparative Molecular Analysis of Wound Repair Summary References 3. Regeneration of Epidermal Structures I. Introduction II. Maintenance Regeneration of Interfollicular Epidermis and Hair III. Regeneration of Nails IV. Regeneration of Cornea V. Regeneration of the Lens VI. Regeneration of Avian and Mammalian Auditory Sensory Cells Summary References 4. Regeneration of Neural Tissues I. Introduction II. Structure of the Nervous System III. Regeneration of Axons IV. Neurogenesis in the Adult CNS Summary References 5. Regeneration of Digestive, Respiratory and Urinary Tissues I. Introduction II. Regeneration of the Intestinal Epithelium III. Regeneration of the Liver IV. Regeneration of the Pancreas V. Regeneration of Respiratory Epithelium VI. Regeneration of Kidney Tubule Epithelium Summary References 6. Regeneration of Musculoskeletal Tissues I. Introduction II. Regeneration of Skeletal Muscle III. Regeneration of Bone IV. Regeneration of Articular Cartilage, Me


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© Academic Press 2012
Academic Press
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About the Author

David Stocum

Affiliations and Expertise

Department of Biology, Indiana University-Purdue University Indianapolis, USA


BMA Medical Book Award 2013: Medicine - Highly Commended, British Medical Association


"...a terrific reference for anyone toying with the idea of moving into this field. The text offers an enormous breath of coverage of different systems currently under investigation, and Stocum provides a central theme that pits regenerative ability against fibrosis as a way to conceptually untangle the limited regenerative capacity of humans...Stocum has erected an umbrella large enough for scientists of diverse backgrounds to initiate conceptual cross-talk between those actively involved in the biology of regeneration and those targeting its clinical application." - Ken Muneoka, Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana “…of tremendous importance to researchers and clinicians working in the fields of regeneration and stem cell biology.” - Jonathan Henry, University of Illinois at Urbana-Champaign “This text integrates information from cell and developmental biology with regenerative biology, tissue engineering and clinical practice. The breadth and detail of this intellectual landscape are derived from the author’s long commitment to the problems of regeneration, and help to make this volume a landmark publication for regenerative medicine.” - Jeremy Brockes, University College London “This book is a superb in-depth analysis of the existing potential of the tissues of the body to replace cells and tissues and how to promote this ability for the sake of repair….Every institute should have it as their background reading and mission statement. I can't recommend it highly enough, it has been long awaited.” - Malcolm Maden, King’s College London “…wonderful and comprehensive, providing readers with the basis of regeneration biology and medicine. The author emphasizes the necessity of understanding the biology of regeneration for a true appreciation of its practice