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Regenerative Biology and Medicine - 1st Edition - ISBN: 9780123693716, 9780080493022

Regenerative Biology and Medicine

1st Edition

Author: David Stocum
Paperback ISBN: 9780123693716
eBook ISBN: 9780080493022
Imprint: Academic Press
Published Date: 28th August 2006
Page Count: 464
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The purpose of the book is to bring together in one place the different facets of regenerative biology and medicine while providing the reader with an overview of the basic and clinically-oriented research that is being done. Not only does the content cover a plethora tissues and systems, it also includes information about the developmental plasticity of adult stem cells and the regeneration of appendages.

As part of its balanced presentation, Regenerative Biology and Medicine does address the biological/bioethical issues and challanges involved in the new and exciting field of regenerative biology and medicine.

Key Features

*Tissues covered include skin, hair, teeth, cornea, and central neural types *Systems presented are digestive, respiratory, urogenital, musculoskeletal, and cardiovascular *Includes amphibians as powerful research models *Discusses appendage regeneration in amphibians and mammals


Researchers and students in biology, chemistry, and bioengineering; medical students; academic and clinical physicians; and research investigators

Table of Contents

Chapter 1: An Overview of Regenerative Biology and Medicine


A Brief History of Regenerative Biology and Medicine

The Biology of Regeneration

  1. Regeneration Takes Place at all Levels of Biological Organization

  2. Mechanisms of Regeneration at the Tissue Level

  3. Epimorphosis and Morphallaxis

  4. Evolutionary Significance of Regeneration and Fibrosis

Strategies of Regenerative Medicine

  1. Cell Transplantation

  2. Bioartificial Tissues

  3. Induction of Regeneration In Situ



Chapter 2: Repair of Skin Wounds by Fibrosis


Structure of Adult Mammalian Skin

The Effect of Wound Type and Extent on Dermal Repair

Phases of Repair in Excisional Wounds

  1. Hemostasis and Clot Formation

  2. Inflammation

  3. Structural Repair

  4. The Role of Wound Contraction in Dermal Repair

Molecular Comparison of Wounded vs. Unwounded Skin

Fetal Skin Heals Without Scarring

  1. Cellular and ECM Differences Between Fetal and Adult Wound Healing

  2. Fetal Wounds have a Minimal Inflammatory Response



Chapter 3: Regeneration of Epidermal Tissues


Regeneration of Epidermis and Hair

  1. Maintenance Regeneration

  2. Injury-Induced Regeneration of the IFE

Regeneration of Nails

Regeneration of Dental Tissues

Regeneration of the Lens

  1. Structure of the Eye and Lens

  2. Cellular Events of Lens Regeneration in the Newt Eye

  3. Transcription Factors Regulating Lens Regeneration

  4. Signals Invlved in Lens Regeneration

  5. Mammals Have Some Capacity for Lens Regeneration

Regeneration of the Cornea



Chapter 4: Regenerative Medicine of Skin, Hair and Dental Tissues


Repair of Skin

  1. Acceleration of Acute Wound Repair by Topically Applied Agents

  2. Acceleration of Repair in Chronic Wounds by Topically Applied Agents

  3. Keratinocyte Transplants

  4. Bioartificial Skin Equivalents

  5. Acellular Dermal Regeneration Templates

Use of Acellular Templates for Abdominal Wall Repair

Stimulation of Hair Regeneration

Repair of Teeth and Peridontium

Corneal Regeneration



Chapter 5: Regeneration of Neural Tissues


Axon Regeneration

  1. Axons of Mammalian Spinal (Peripheral) Nerves

  2. Axons of Mammalian Spinal Cord

3, Axons of Amphibian Spinal Cord

  1. Axons of Amphibian and Fish Optic Nerve

Maintenance Regeneration of Neurons in the Mammalian CNS

  1. Discovery of Neural Stem Cells

  2. Regeneration of Olfactory Nerve and Bulb Neurons

  3. Regeneration of Hippocampal Neurons

  4. Regeneration of Cortical Neurons

  5. The CNS Neural Stem Cell Microniche

Injury-Induced CNS Regeneration

  1. Avian and Mammalian Auditory Sensory Neurons

  2. Regeneration of Neurons in the Mammalian Brain

  3. Regeneration of the Retina

  4. Regeneration of the Spinal Cord in Amputated Amphibian and Lizard Tails



Chapter 6: Regenerative Medicine of Neural Tissues


Therapies for Injured Peripheral Nerve

Therapies for Injured Spinal Cord

  1. Pharmaceutical Therapies

  2. Regeneration Templates

  3. Cell Transplant Therapies

  4. Bioartificial Spinal Cord

  5. Rehabilitation Programs and Synaptic Plasticity

  6. Combinatorial Approaches May Bring Better Success

Therapies for Neurodegenerative Diseases

  1. Demyelinating Disorders

  2. Parkinson¡¦s Disease

  3. Huntington¡¦s Disease

  4. Alzheimer¡¦s Disease

  5. Amyotrophic Lateral Sclerosis



Chapter 7: Regeneration of Digestive, Respiratory and Urogenital Tissues


Intestinal Epithelium

  1. Structure of the Intestinal Tract

  2. Regeneration of the Villous Epithelium

  3. Regeneration of Transected Intestine


  1. Structure and Function of the Mammalian Liver

  2. Regeneration by Compensatory Hyperplasia

  3. Injury-Induced Regeneration via Stem Cells

  4. Heterogeneity of Hepatocyte Size and Growth Potential


  1. Structure and Function of the Pancreas

  2. Regeneration of the Pancreas

  3. Origin of Regenerated ƒÒ-Cells

Alveolar Epithelium of the Lung

  1. Structure of the Respiratory System

  2. Regeneration of Alveolar Epithelium

Kidney and Urinary System

  1. Structure of the Kidney and Urinary System

  2. Regeneration of Kidney Tubule Epithelium


Prostate Tissue



Chapter 8: Regenerative Medicine of Digestive, Respiratory and Urinary Tissues


Regenerative Therapies for the Liver

  1. Hepatocyte Transplants

  2. Extracorporeal Liver Assist Devices

Regenerative Therapies for the Pancreas

  1. Cell Transplants

  2. Suppression of Autoimmunity and Regeneration From Remaining ƒÒ-Cells

  3. Bioartificial Pancreas

  4. Gene Therapy to Induce Islet Neogenesis

Regenerative Therapies for the Esophagus and Intestine

  1. Esophagus

  2. Intestine

Regenerative Therapies for the Respiratory System

  1. Trachea

  2. Lung

Regenerative Therapies for the Urinary System

  1. Nephrons

  2. Urinary Conduit Tissue



Chapter 9: Regeneration of Musculoskeletal Tissues


Regeneration of Skeletal Muscle

  1. Structure of Skeletal Muscle

  2. Satellite Cells are the Source of Regenerated Muscle

  3. Cellular and Molecular Events of Skeletal Muscle Regeneration

  4. The Activation and Proliferation of SCs is Regulated by a Variety of Signaling Molecules

  5. Tension and Innervation are Required for Normal Muscle Regeneration

Regeneration of Bone

  1. Structure of Bone

  2. Maintenance Regeneration of Bone

  3. Injury-Induced Regeneration of Bone

Repair of Articular Cartilage

Repair of Tendon and Ligament

  1. Structure of Tendons and Ligaments

  2. Repair of Tendons and Ligaments



Chapter 10: Regenerative Medicine of Musculoskeletal Tissues


Regenerative Therapies for Muscle

  1. Muscular Dystrophy

  2. Bioartificial Muscle

Regenerative Therapies for Meniscus and Articular Cartilage

  1. Meniscus

  2. Articular Cartilage

Regenerative Therapies for Bone

  1. Electromagnetic Field Stimulation

  2. Ilizarov Distraction Technique for Lengthening Bones

  3. Induction of Bone Regeneration by Osteogenic Factors and Acellular Templates

  4. Cell Transplants and Bioartificial Bone

  5. The Long Bones of Salamanders Can Regenerate When Removed

Regenerative Therapies for Tendon and Ligament

  1. Tendon

  2. Ligament



Chapter 11: Regeneration of Hematopoietic and Cardiovascular Tissues


Regeneration of Hematopoietic Cells

  1. Composition of Adult Blood

  2. Hematopoietic Stem Cells of the Bone Marrow

  3. Regulation of LT-HSC Activation and Proliferation

Regeneration of Blood Vessels

  1. Development and Structure of the Vascular System

  2. Blood Vessel Regeneration in Wounded Tissue

Regeneration of Cardiac Muscle

  1. Structure of Cardiac Muscle

  2. Mammalian Cardiac Muscle Does Not Regenerate, but Harbors Adult Stem Cells

  3. Amphibian and Zebrafish Cardiac Muscle Regenerates When Injured



Chapter 12: Regenerative Medicine of Hematopoietic and Cardiovascular Tissues


Therapies for Hematopoietic Disorders

  1. Myeloablative Therapy

  2. Non-Myeloablative Therapy

  3. The Future of Hematopoietic Transplants

  4. Gene Therapy for Genetic Hematopoietic Diseases

Therapies for Blood Vessel Regeneration

  1. Stem Cell Transplants

  2. Acellular Regeneration Templates

  3. Bioartificial Blood Vessels

Therapies for Protection and Regeneration of the Infarcted Myocardium

  1. Transplants of Bone Marrow Cells

  2. Satellite Cell Transplants

  3. Cardiomyocyte Transplants

  4. Soluble Factors and Myocardial Regeneration

  5. Bioartificial Cardiac Muscle


Chapter 13: Regenerative Medicine: Developmental Plasticity of Adult Stem Cells


Assays to Test Developmental Plasticity
Experimental Results

  1. Neural Stem Cells

  2. Satellite Cells

  3. Liver Oval Cells

  4. Dental Pulp Cells

  5. Unfractionated Bone Marrow and HSCs

  6. MSCs of the Bone Marrow and Related MSCs

Many Reports of Lineage Conversion are Due to Fusion With Host Cells

Adult Stem Cell Pluripotency: Fact or Fiction?

Might Organisms Contain ESC-Like Stem Cells in Their Tissues?

Effects of Aging on Number and Developmental Status of Regeneration-Competent Cells



Chapter 14: Regeneration of Appendages


Amphibian Limb Regeneration

  1. Events of Limb Regeneration

  2. Origin of the Blastema

  3. Mechanism of Blastema Formation

  4. Epidermal and Neural Requirements for Survival and Proliferation of Blastema Cells

  5. Developmental Plasticity of Blastema Cells in Regenerating Amphibian Limbs

  6. Spatial Organization of Tissue Patterns in the Regenerating Limb

  7. Stimulation of Frog Limb Regeneration

  8. Comparative Analysis of Gene Activity in Regeneration-Competent vs. Regeneration-Deficient Limbs

Regeneration of Amphibian Jaws

Appendage Regeneration in Mammals

  1. Regeneration of Ear Tissue

  2. Regeneration of Deer Antlers

  3. Regeneration of Mouse and Human Digit Tips

  4. Stimulation of Digit and Limb Regeneration in Mice and Rats



Chapter 15: Research Issues in Regenerative Medicine


Biological Issues and Challenges.

  1. Cell Sources for Transplantation and Bioartificial Tissue Construction

  2. Expansion and Directed Differentiation of Regeneration-Competent Cells xiii

  3. Challenges for Bioartificial Tissue Construction

  4. The Challenge of Immunorejection

  5. Challenges for the Chemical Induction of Regeneration

  6. The Challenge of Curing Disease

Bioethical Issues and Challenges

  1. The Derivation of Designer Human ESCs by SCNT

  2. The Controversy Over Human ESC Research

  3. Resolving an Unresolvable Dilemma

  4. The Specter of Interspecies Grafting

Concluding Remarks




No. of pages:
© Academic Press 2006
28th August 2006
Academic Press
Paperback ISBN:
eBook ISBN:

About the Author

David Stocum

Affiliations and Expertise

Department of Biology, Indiana University-Purdue University Indianapolis, USA


"...a terrific reference for anyone toying with the idea of moving into this field. The text offers an enormous breath of coverage of different systems currently under investigation, and Stocum provides a central theme that pits regenerative ability against fibrosis as a way to conceptually untangle the limited regenerative capacity of humans...Stocum has erected an umbrella large enough for scientists of diverse backgrounds to initiate conceptual cross-talk between those actively involved in the biology of regeneration and those targeting its clinical application." - Ken Muneoka, Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana “…of tremendous importance to researchers and clinicians working in the fields of regeneration and stem cell biology.” - Jonathan Henry, University of Illinois at Urbana-Champaign “This text integrates information from cell and developmental biology with regenerative biology, tissue engineering and clinical practice. The breadth and detail of this intellectual landscape are derived from the author’s long commitment to the problems of regeneration, and help to make this volume a landmark publication for regenerative medicine.” - Jeremy Brockes, University College London “This book is a superb in-depth analysis of the existing potential of the tissues of the body to replace cells and tissues and how to promote this ability for the sake of repair….Every institute should have it as their background reading and mission statement. I can't recommend it highly enough, it has been long awaited.” - Malcolm Maden, King’s College London “…wonderful and comprehensive, providing readers with the basis of regeneration biology and medicine. The author emphasizes the necessity of understanding the biology of regeneration for a true appreciation of its practice in clinical medicine.” - Katsutoshi Yoshizato, University of Hiroshima

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