Regenerative Biology and Medicine

1st Edition

Authors: David Stocum
Paperback ISBN: 9780123693716
eBook ISBN: 9780080493022
Imprint: Academic Press
Published Date: 28th August 2006
Page Count: 464
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The purpose of the book is to bring together in one place the different facets of regenerative biology and medicine while providing the reader with an overview of the basic and clinically-oriented research that is being done. Not only does the content cover a plethora tissues and systems, it also includes information about the developmental plasticity of adult stem cells and the regeneration of appendages.

As part of its balanced presentation, Regenerative Biology and Medicine does address the biological/bioethical issues and challanges involved in the new and exciting field of regenerative biology and medicine.

Key Features

Tissues covered include skin, hair, teeth, cornea, and central neural types Systems presented are digestive, respiratory, urogenital, musculoskeletal, and cardiovascular Includes amphibians as powerful research models Discusses appendage regeneration in amphibians and mammals


Researchers and students in biology, chemistry, and bioengineering; medical students; academic and clinical physicians; and research investigators

Table of Contents

Chapter 1: An Overview of Regenerative Biology and Medicine


A Brief History of Regenerative Biology and Medicine

The Biology of Regeneration

  1. Regeneration Takes Place at all Levels of Biological Organization

  2. Mechanisms of Regeneration at the Tissue Level

  3. Epimorphosis and Morphallaxis

  4. Evolutionary Significance of Regeneration and Fibrosis

Strategies of Regenerative Medicine

  1. Cell Transplantation

  2. Bioartificial Tissues

  3. Induction of Regeneration In Situ



Chapter 2: Repair of Skin Wounds by Fibrosis


Structure of Adult Mammalian Skin

The Effect of Wound Type and Extent on Dermal Repair

Phases of Repair in Excisional Wounds

  1. Hemostasis and Clot Formation

  2. Inflammation

  3. Structural Repair

  4. The Role of Wound Contraction in Dermal Repair

Molecular Comparison of Wounded vs. Unwounded Skin

Fetal Skin Heals Without Scarring

  1. Cellular and ECM Differences Between Fetal and Adult Wound Healing

  2. Fetal Wounds have a Minimal Inflammatory Response



Chapter 3: Regeneration of Epidermal Tissues


Regeneration of Epidermis and Hair <BR


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© Academic Press 2006
Academic Press
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About the Author

David Stocum

Affiliations and Expertise

Department of Biology, Indiana University-Purdue University Indianapolis, USA


"...a terrific reference for anyone toying with the idea of moving into this field. The text offers an enormous breath of coverage of different systems currently under investigation, and Stocum provides a central theme that pits regenerative ability against fibrosis as a way to conceptually untangle the limited regenerative capacity of humans...Stocum has erected an umbrella large enough for scientists of diverse backgrounds to initiate conceptual cross-talk between those actively involved in the biology of regeneration and those targeting its clinical application." - Ken Muneoka, Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana “…of tremendous importance to researchers and clinicians working in the fields of regeneration and stem cell biology.” - Jonathan Henry, University of Illinois at Urbana-Champaign “This text integrates information from cell and developmental biology with regenerative biology, tissue engineering and clinical practice. The breadth and detail of this intellectual landscape are derived from the author’s long commitment to the problems of regeneration, and help to make this volume a landmark publication for regenerative medicine.” - Jeremy Brockes, University College London “This book is a superb in-depth analysis of the existing potential of the tissues of the body to replace cells and tissues and how to promote this ability for the sake of repair….Every institute should have it as their background reading and mission statement. I can't recommend it highly enough, it has been long awaited.” - Malcolm Maden, King’s College London “…wonderful and comprehensive, providing readers with the basis of regeneration biology and medicine. The author emphasizes the necessity of understanding the biology of regeneration for a true appreciation of its practice