Reflections on a Century of Malaria Biochemistry

Reflections on a Century of Malaria Biochemistry

1st Edition - November 27, 2008

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  • Author: Irwin Sherman
  • eBook ISBN: 9780080921839

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Malaria is one of the most common infectious diseases and an enormous public health problem. Each year it causes disease in approximately 650 million people and kills between 1 and 3 million, most of them young children in Sub-Saharan Africa. This book provides an overview of the research that has been done in malaria biochemistry in the quest to find a cure. It discusses how our understanding has helped us to develop better diagnostics and novel chemotherapies. Researchers will find having all of this information in one volume, annotated with personal reflections from a leader in the field, invaluable given the big push being made on various fronts to use the latest drug discovery tools to attack malaria and other developing country diseases.

Key Features

* Reviews the past 100 years of malaria biochemistry research providing researchers with an overview of the investigations that have been undertaken in this field
Benefit: Allows researchers to see what progress has been made so that they can use this knowledge when trying to develop the latest drug discovery tools to attack malaria

* Chronicles both biochemical successes and failures
Benefit: Allows researchers to see what has and hasn't work which they can then apply in their own research


Researchers in parasitology, tropical medicine and entomology.

Table of Contents

  • 1. An Introduction to Malaria Parasites
    2. The Early Years
    3. Show Me The Money
    4. In vivo and in vitro models
    a. Life in the Erythrocyte
    b. Life Outside the Erythrocyte
    c. Life in the Mosquito
    5. Malaria Pigment
    6. Chloroquine and Hemozoin
    7. Isoenzymes
    8. The Road to the Plasmodium falciparum Genome
    9. Carbohydrate metabolism
    a. Glycolysis and the TCA Cycle
    b. The Pentose Phosphate Pathway
    c. Pyridine nucleotides
    d. Carbon dioxide fixation
    10. Pyrimidines and the Mitochondrion
    11. The Road to Atovaquone
    12. The Ring Road to the Apicoplast
    13. Ribosomes and Ribosomal RNA Synthesis
    14. De Novo Synthesis of Pyrimidines and Folates
    15. Salvage of Purines
    16. Polyamines
    17. New Permeability Pathways and Transport
    18. Hemoglobinases
    19. Membrane Proteins
    20. Trafficking
    21. Membrane Lipids
    22. Adhesion
    a. Adhesion Without Knobs
    b. Cerebral Malaria
    23. Invasion
    24. Vitamins and Antioxidants
    25. Shocks and Clocks
    26. Transcriptomes, Proteomes and Data Mining
    27. Mosquito Interactions

Product details

  • No. of pages: 400
  • Language: English
  • Copyright: © Academic Press 2008
  • Published: November 27, 2008
  • Imprint: Academic Press
  • eBook ISBN: 9780080921839

About the Author

Irwin Sherman

Affiliations and Expertise

The Scripps Research Institute, La Jolla, CA, USA

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