Recombinant DNA and Genetic Experimentation

Recombinant DNA and Genetic Experimentation

Proceedings of a Conference on Recombinant DNA, Jointly Organised by the Committee on Genetic Experimentation (COGENE) and the Royal Society of London, Held at Wye College, Kent, UK, 1-4 April, 1979

1st Edition - January 1, 1979

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  • Editors: Joan Morgan, W. J. Whelan
  • eBook ISBN: 9781483147062

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Description

Recombinant DNA and Genetic Experimentation contains papers from the Proceedings of a Conference on Recombinant DNA held in London on April 1-4, 1979. This books reviews recombinant DNA research and discusses advances in the application of recombinant DNA research and the regulations affecting such research. Part 1 of the book deals with recombinant DNA techniques that are useful in the biological perspective. These techniques include tests for rare gene exchanger and laboratory genetic manipulations. Part 2 addresses the achievements of recombinant DNA research such as the detection of homologous sequences and progress made in the research of animal viruses. Part 3 discusses the practical benefits of recombinant DNA research, covering topics such as the production of valuable proteins in alternate biological hosts. These proteins are shown as being valuable to society, besides being scientific curiosities. An important presentation is Part 4 of the symposium, which discusses the guidelines and legislations affecting recombinant DNA research such as prior restraint, prohibitions, risks, and approval of the conduct of such experiments. Part 5 concerns a review of the basic assumptions made in the symposium, while Part 6 tackles the question of what options are left open in the international arena, in the medical field, and in the eyes of the public. This collection of papers can prove beneficial for molecular biologists, DNA researchers, molecular geneticists, ecologists and endocrinologists, and pharmacologists.

Table of Contents


  • Preface

    Participants

    Introduction and Welcome

    The Purpose of the Meeting

    Recombinant DNA Techniques Put into Biological Perspective

    Chairman's Introduction

    Evolution and Stability of Species

    Discussion

    Organization and Evolution of the Eukaryotic Genome

    Discussion

    Natural Modes of Genetic Exchange and Change

    Discussion

    Transposons and Insertion Sequences

    Discussion

    Laboratory Genetic Manipulations

    Discussion

    Achievements of Recombinant DNA Research

    Experimental Techniques and Strategies for DNA Cloning

    Application of Recombinant DNA Technology in the Molecular Genetics of Prokaryotes

    New Insights into the Molecular Genetics of Animals

    Discussion

    Recombinant DNA and Animal Viruses: Progress and Prospects

    Discussion

    Chairman's Introduction

    New Insights into the Molecular Genetics of Fungi and Plants

    Discussion

    Recombinant DNA and Agricultural Research

    Discussion

    Expression of Foreign Genes

    Discussion

    Practical Benefits of Recombinant DNA Research

    Chairman's Introduction

    Production of "Valuable" Proteins in Alternate Biological Hosts

    The Expression of a Cloned Rabbit Chromosomal ß-Globin Gene in Mouse L Cells and Yeast

    Discussion

    Guidelines and Legislation

    Chairman's Introduction

    A History of the Recombinant DNA Guidelines in the United States

    The Early History of the Recombinant DNA Molecule Program Advisory Committee of NIH

    How the NIH Recombinant DNA Molecule Committee Works in 1979

    Discussion

    Guidelines, Legislation and Labor Relations

    Discussion

    Recombinant DNA Guidelines and Legislation

    Summary of Report to COGENE of the Working Group on Recombinant DNA Guidelines

    Discussion

    Re-examination of Basic Assumptions

    Chairman's Introduction

    Why the "Berg" Letter was Written

    Discussion

    Biological Activity of Polyoma-Plasmid and Polyoma-Phage Recombinants in Mice and Hamsters

    Infectivity of Polyoma Virus-Plasmid pBR322 and Polyoma Virus-Lambda Recombinants in Mouse Fibroblasts

    Discussion

    Second Report of the COGENE Working Group on Risk Assessment

    Discussion

    What Lessons Does the Recombinant DNA Debate Teach Us - A Round Table Discussion

    Discussion

    What Options are Now Open?

    Chairman's Introduction

    International Legal Aspects of Recombinant DNA Research

    Discussion

    Recombinant DNA: A Public Health Viewpoint

    Discussion

    The View of a Science Journalist

    Discussion

    Historical Perspectives on the Recombinant DNA Controversy

    The Public Perception of Risk

    Discussion

    The View of a Legislator and a Summary of the Conference

Product details

  • No. of pages: 334
  • Language: English
  • Copyright: © Pergamon 1979
  • Published: January 1, 1979
  • Imprint: Pergamon
  • eBook ISBN: 9781483147062

About the Editors

Joan Morgan

W. J. Whelan

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