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Reciprocal Translation Between Pathophysiology and Practice in Health and Disease brings a novel perspective, closing the knowledge gap between normal/abnormal physiology. Chapters describe the basic mechanisms underlying a disease or trauma-related response, describe consequences in practice, and provide insights on how to use information to better understand disease outcomes. Other sections explore how these responses are beneficial and driven by similar hormones and inflammatory immune cell derived modulators. This is a must-have resource for those seeking an authoritative and comprehensive understanding on how to treat the basic mechanisms underlying disease or trauma-related responses.
- Provides an overview of fundamental/foundational content and then goes on to translate the information to more clinically-oriented perspectives
- Highlights the benefit of normal pathophysiological response to stress and the misunderstandings surrounding the treatment of this response
- Explains how treatment should be adapted to support the inflammatory response and how to treat its inflammatory cause
- Includes case studies and slides
Basic researchers, clinical researchers and clinicians in the life sciences and medicine interested in understanding and treating the basic mechanisms underlying disease or trauma-related responses
PART I. PATHOPHYSIOLOGICAL MECHANISMS IN DISEASE
1. Reciprocal translation between pathophysiology and practice in health and disease
2. General principles of the repair mechanism
3. Cardiovascular responses to injury
4. Insulin resistance as an adaptive mechanism
5. Hypercholesterolemia, harm or benefit?
6. Macronutrient metabolism in starvation and stress
7. The role of ectopic adipose tissue: benefit or deleterious overflow?
8. The gut/liver axis, inflammation and the pathogenesis of metabolic syndrome
9. Harm and benefit of the inflammatory response
PART II. CLINICAL MANIFESTATIONS OF ADAPTIVE PATHOPHYSIOLOGY
10. The beneficial role of inflammation and metabolic cycling (Warburg revisited)
11. From hepatic encephalopathy to the quality of food protein and pro-tein requirements: a serendipitous journey
12. The underlying metabolism of hypoalbuminemia and its clinical effects
13. Cardiovascular stress syndromes
14. The benefit of moderate hyperglycemia and hyperlactatemia in critical illness or synthesis of biomass
15. Anemia as an adaptive phenomenon
16. Vitamin D in health and disease
PART III. IMPLICATIONS FOR TREATMENT
17. Decreases of plasma solutes in health and disease: deficiency or resulting from changing binding proteins and distribution volume?
18. Comparable metabolism in pregnancy and cancer: a universal role of the Warburg effect
19. Nutritional assessment and the role of pre-existent inflammation with a bearing on COVID-19
20. The harm afflicted by NSAIDs, statins and oral antidiabetics by blocking adaptive inflammatory metabolism
21. Benefit and concern of ketogenic and vegan diets: a revisit to pathophysiology
PART IV. MECHANISMS PROVIDING INSIGHT IN A FEW ENIGMATIC SYNDROMES
22. Pathophysiology in practice: How to manage gastrointestinal surgery in acute and elective disease conditions
23. The pathophysiology underlying the obesity and plasma cholesterol paradoxes
24. The final conclusion: dogma, bias and big data
- No. of pages:
- © Academic Press 2021
- 18th March 2021
- Academic Press
- Paperback ISBN:
Peter B. Soeters, MD, PhD is Emeritus Professor of Surgery at Maastricht University and retired in 2006. He has been a licensed surgeon and intensivist and after starting general surgery gradually focused on patients with abdominal catastrophe (inflammatory bowel disease, postoperative or spontaneous abdominal complications) and morbid obesity. He introduced artificial nutrition in 1970 in the Netherlands. In 1984 he established a surgical laboratory, in which interorgan inflammatory metabolism was studied in small and larger animal models and studies in humans were supported. He supervised 35-40 PhD students addressing these issues. Twelve of these PhD students became full professors. He published 280 peer reviewed papers, 65% of them as first or last author (H-index 72) He held several positions in Surgical, Gastroenterological, Hepatological, Nutritional/ Metabolic Societies and scientific journals nationally and internationally, and holds 8 honorary memberships of these societies. He was knighted in the order of the Dutch Lion in 2006.
Emeritus Professor of Surgery, Maastricht University Medical Center, Maastricht, The Netherlands
Peter de Leeuw, MD, PhD is emeritus professor of Medicine at the University of Maastricht. His research interest is in cardiovascular medicine. He has published over 480 articles and reviews and served on the editorial board of more than 20 international journals. He also served as Editor-in-Chief of the Netherlands Journal of Medicine, the European Journal of Internal Medicine and the Nederlands Tijdschrift voor Geneeskunde (Dutch Medical Journal). He organized several congresses and symposia and was a steering member on several international trials. He is a member of multiple scientific societies and served in the Council of the International Society of Hypertension. For his scientific work, he received several awards from the High Blood Pressure Research Council of Australia, the European Federation of Internal Medicine and the European Society of Hypertension.
Emeritus Professor, Department of Medicine, Maastricht University Medical Center, Maastricht, The Netherlands
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