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Reciprocal Translation Between Pathophysiology and Practice in Health and Disease brings a novel perspective, closing the knowledge gap between normal/abnormal physiology. Chapters describe the basic mechanisms underlying a disease or trauma-related response, describe consequences in practice, and provide insights on how to use information to better understand disease outcomes. Other sections explore how these responses are beneficial and driven by similar hormones and inflammatory immune cell derived modulators. This is a must-have resource for those seeking an authoritative and comprehensive understanding on how to treat the basic mechanisms underlying disease or trauma-related responses.
- Provides an overview of fundamental/foundational content and then goes on to translate the information to more clinically-oriented perspectives
- Highlights the benefit of normal pathophysiological response to stress and the misunderstandings surrounding the treatment of this response
- Explains how treatment should be adapted to support the inflammatory response and how to treat its inflammatory cause
- Includes case studies and slides
Basic researchers, clinical researchers and clinicians in the life sciences and medicine interested in understanding and treating the basic mechanisms underlying disease or trauma-related responses
PART I PATHOPHYSIOLOGICAL MECHANISMS IN DISEASE
1. General introduction
2. General principles of the repair mechanism
3. Cardiovascular responses
4. Delivery of essential substrates
5. The role of ectopic lipid metabolism
6. The role of insulin resistance and inflammation
7. The Warburg effect
8. From the gut-liver axis to the biological value of protein: a serendipitous journey
PART II CLINICAL MANIFESTATIONS OF ADAPTIVE PATHOPHYSIOLOGY
10. Cardiovascular stress syndromes
11. Hyperglycemia during severe illness
13. (Pseudo)-deficiency syndromes
14. Conditions of growth
15. The benefit of the symptoms of Celsus
16. When adaptive pathophysiology fails or creates harm
PART III IMPLICATIONS FOR TREATMENT
17. Optimizing clinical trials
18. Nutritional assessment
19. Treatment of symptoms or causes
20. Benefit and concern of the Enhanced Recovery After Surgery program
21. Application of pathophysiological principles in patients with abdominal catastrophe
PART IV MECHANISMS PROVIDING INSIGHT IN A FEW ENIGMATIC SYNDROMES
22. The non-paradoxical character of the obesity paradox
23. The conditional role of inflammation in Pregnancy and Cancer
24. Overall conclusions and the viscosity of old insights
- No. of pages:
- © Academic Press 2021
- 1st March 2021
- Academic Press
- Paperback ISBN:
Peter B. Soeters, MD, PhD is Emeritus Professor of Surgery at Maastricht University and retired in 2006. He has been a licensed surgeon and intensivist and after starting general surgery gradually focused on patients with abdominal catastrophe (inflammatory bowel disease, postoperative or spontaneous abdominal complications) and morbid obesity. He introduced artificial nutrition in 1970 in the Netherlands. In 1984 he established a surgical laboratory, in which interorgan inflammatory metabolism was studied in small and larger animal models and studies in humans were supported. He supervised 35-40 PhD students addressing these issues. Twelve of these PhD students became full professors. He published 280 peer reviewed papers, 65% of them as first or last author (H-index 72) He held several positions in Surgical, Gastroenterological, Hepatological, Nutritional/ Metabolic Societies and scientific journals nationally and internationally, and holds 8 honorary memberships of these societies. He was knighted in the order of the Dutch Lion in 2006.
Emeritus Professor of Surgery, Maastricht University Medical Center, Maastricht, The Netherlands
Peter de Leeuw, MD, PhD is emeritus professor of Medicine at the University of Maastricht. His research interest is in cardiovascular medicine. He has published over 480 articles and reviews and served on the editorial board of more than 20 international journals. He also served as Editor-in-Chief of the Netherlands Journal of Medicine, the European Journal of Internal Medicine and the Nederlands Tijdschrift voor Geneeskunde (Dutch Medical Journal). He organized several congresses and symposia and was a steering member on several international trials. He is a member of multiple scientific societies and served in the Council of the International Society of Hypertension. For his scientific work, he received several awards from the High Blood Pressure Research Council of Australia, the European Federation of Internal Medicine and the European Society of Hypertension.
Emeritus Professor, Department of Medicine, Maastricht University Medical Center, Maastricht, The Netherlands
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