Advances in Pharmacology and Therapeutics, Volume l: Receptors contains the proceedings of the 7th International Congress of Pharmacology held in Paris, France, in 1978. The papers explore advances in the understanding of receptors, their pharmacology, and their therapeutic applications. Topics covered range from opiate receptors and their endogenous ligands to membrane receptors in eukaryotic cells. Applications of binding to pharmacological research are also discussed. This volume is comprised of 29 chapters and opens with an overview of the chemistry and biochemistry of pituitary endorphins, paying particular attention to the correlation between the analgesic potency, receptor binding properties, preferred solution conformation, and metabolic stability of natural and synthetic opioid peptides. The reader is then introduced to the biosynthesis and release of the enkephalins; opiate receptors and their endogenous ligands; denervation supersensitivity in skeletal muscle; and biochemistry and physiology of dopaminergic and beta-adrenergic receptors in mammalian central nervous system. The following chapters explore the role of guanylnucleotides in the regulation of hormonally stimulated adenylate cyclase; interactions of cholera toxin with cell membranes; problems in studying hormone receptor binding; and the mechanism of action of anti-hormones. This book will be of interest to practitioners in biosciences, pharmacology, physiology, and medicine.
Introduction Opiate Receptors and their Endogenous Ligands Chemistry and Biochemistry of Pituitary Endorphins Multiple Opiate Receptors Pituitary Endorphins: Recent Progress The Biosynthesis and Release of the Enkephalins Opiate Receptors: A) Functional Heterogeneity Demonstrated with an Apparently Irreversible Naloxone Derivative B) Regulation by Guanine Nucleotides Opiate Receptors, their Endogenous Ligands and the Development of Tolerance/Dependence Physiological and Pathophysiological Relevance of the Endogenous Ligands of the Opiate Receptors Membrane Receptors in E ucaryotic Cells Multiple Classes of Muscarinic Receptor Binding Sites in the Brain Biophysical Aspects of Agonist Action at Frog Endplate Some Observations on Denervation Supersensitivity in Skeletal Muscle Structural and Functional Properties of the Acetylcholine-Regulator Glutamate Receptors in Eucaryotes Biochemistry and Physiology of Dopaminergic and Beta-Adrenergic Receptors in Mammalian Central Nervous System Beta-Adrenergic Receptors in C6 Glioma Cells and Central Nervous System Recent Studies on Opiate Receptors The Role of Quanylnucleotides in the Regulation of Hormonally Stimulated Adenylate Cyclase Catecholamine-Sensitive Adenylate Cyclase: Identification and Partial Characterization of Some of its Components Interactions of Cholera Toxin with Cell Membranes Hybridization of Hormone Receptors with Adenylate Cyclase Systems of Different Cells Receptor Binding Studies of Beta-Adrenergic Receptors: New Insights into Activation and Desensitization of Adenylate Cyclase Applications of Binding to Pharmacological Research Control of Hormone Receptor Levels and Function Problems in Studying Hormone Receptor Binding Methodological Approach to Radioligand Binding Studies of Adrenergic Receptors Main Lectures Synaptic Receptor Proteolipids: Is
- No. of pages:
- © Pergamon 1979
- 1st January 1979
- eBook ISBN: