Receptors - 1st Edition - ISBN: 9780121852719, 9781483259703


1st Edition

Model Systems and Specific Receptors

Editors: P. Michael Conn
eBook ISBN: 9781483259703
Imprint: Academic Press
Published Date: 1st April 1993
Page Count: 456
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Methods in Neurosciences, Volume 11: Receptors: Model Systems and Specific Receptors is a compilation of papers that describes techniques and information that are important to the neurosciences. This volume discusses preferred receptor techniques, molecular techniques, and methods to determine receptor subclasses and localization in the ligand design.
The first paper discusses the steroid receptor found in the central nervous system for steroid hormones that affects strongly the structure and function of both developed and immature nervous systems. Another paper describes how a glycoprotein of 79.5 kDa (transferrin) carries iron in the blood stream for delivery to different tissues, after the transferrin has bound with a specific receptor on the surface of the cell. This book also explains the binding sites of pituitary adenylate cyclase-activating polypeptide in the human brain, while one paper analyzes the neurotensin receptors during the primary culture of neurons. This volume then also analyzes the structure and function of the fast nerve growth factor receptor, particularly how a signal on the outside of a cell is transmitted to the cell's interior.
This collection is helpful for microbiologists, cellular researchers, students, and professors in the discipline of neurosciences.

Table of Contents

Contributors to Volume 11


Volumes in Series

1. Steroid Receptors in the Central Nervous System

2. Membrane Receptor for Glucocorticoids in Mammalian Neurons

3. Interleukin 1 Receptors in the Brain-Endocrine-Immune Axis

4. Vasoactive Peptides and Their Receptors

5. Melanotropin Receptors of the Brain

6. Melatonin Binding Sites

7. Transferrin Receptors in the Central Nervous System

8. Binding Sites of Pituitary Adenylate Cyclase-Activating Polypeptide in Human Brain

9. Role of Cholecystokinin Type B Receptor in Nociception Studied with Peptide Agonists and Antagonists

10. Cholecystokinin Receptors: Radioligand Binding and Afñnity Labeling

11. Endothelin Receptors in Neural Systems

12. Natriuretic Peptide Receptors

13. Structural and Functional Identification of Insulin-like Growth Factor Receptors

14. Methods for Studying Central Serotonergic Receptors

15. Analysis of Serotonin 5-HT1A Receptors in Primary Neuronal Culture

16. Characterization of the Bombesin/Gastrin-Releasing Peptide Receptor in Swiss 3T3 Fibroblasts

17. Receptors for Bombesinlike Peptides in the Rat Central Nervous System

18. Retinal Insulin Receptors

19. Pancreatic Polypeptide Receptors in Rat Brain

20. Neurotensin Receptors in Primary Culture of Neurons

21. Analysis of the Structure and Function of the Fast Nerve Growth Factor Receptor

22. Solubilization and Physicochemical Characterization of 5-HT3 Receptor-Binding Sites

23. Solubihzadon and Characterization of the Receptor for Gastrin-Releasing Peptide

24. Assays for Pituitary Adenylate Cyclase-Acdvadng Peptide Receptors Coupled to Adenylate Cyclase: Comparison between Rat Brain and Human Neuroblastoma Cells



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© Academic Press 1993
Academic Press
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About the Editor

P. Michael Conn

P. Michael Conn is the Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center. He is The Robert C. Kimbrough, Professor of Internal Medicine and Cell Biology/Biochemistry. He was previously Director of Research Advocacy and Professor of Physiology and Pharmacology, Cell Biology and Development and Obstetrics and Gynecology at Oregon Health and Science University and Senior Scientist of the Oregon National Primate Research Center (ONPRC). He served for twelve years as Special Assistant to the President and Associate Director of the ONPRC. After receiving a B.S. degree and teaching certification from the University of Michigan (1971), a M.S. from North Carolina State University (1973), and a Ph.D. degree from Baylor College of Medicine (1976), Conn did a fellowship at the NIH, then joined the faculty in the Department of Pharmacology, Duke University Medical Center where he was promoted to Associate Professor in 1982. In 1984, he became Professor and Head of Pharmacology at the University of Iowa College of Medicine, a position he held for eleven years. Conn is known for his research in the area of the cellular and molecular basis of action of gonadotropin releasing hormone action in the pituitary and therapeutic approaches that restore misfolded proteins to function. His work has led to drugs that have benefitted humans and animals. Most recently, he has identified a new class of drugs, pharmacoperones, which act by regulating the intracellular trafficking of receptors, enzymes and ion channels. He has authored or co-authored over 350 publications in this area and written or edited over 200 books, including texts in neurosciences, molecular biology and endocrinology. Conn has served as the editor of many professional journals and book series (Endocrinology, Journal of Clinical Endocrinology and Metabolism, Endocrine, Methods, Progress in Molecular Biology and Translational Science and Contemporary Endocrinology). Conn served on the National Board of Medical Examiners, including two years as chairman of the reproduction and endocrinology committee. The work of his laboratory has been recognized with a MERIT award from the NIH, the J.J. Abel Award of the American Society for Pharmacology and Experimental Therapeutics, the Weitzman, Oppenheimer and Ingbar Awards of the Endocrine Society, the National Science Medal of Mexico (the Miguel Aleman Prize) and the Stevenson Award of Canada. He is the recipient of the Oregon State Award for Discovery, the Media Award of the American College of Neuropsychopharmacology and was named a distinguished Alumnus of Baylor College of Medicine in 2012. Conn is a previous member of Council for the American Society for Cell Biology and the Endocrine Society and is a prior President of the Endocrine Society, during which time he founded the Hormone Foundation and worked with political leadership to heighten the public’s awareness of diabetes. Conn’s students and fellows have gone on to become leaders in industry and academia. He is an elected member of the Mexican Institute of Medicine and a fellow of the American Association for the Advancement of Science. He is the co-author of The Animal Research War (2008) and many articles for the public and academic community on the value of animal research and the dangers posed by animal extremism. His op/eds have appeared in The Washington Post, The LA Times, The Wall Street Journal, the Des Moines Register, and elsewhere. Conn consults with organizations that are influenced by animal extremism and with universities and companies facing challenges from these groups.

Affiliations and Expertise

Texas Tech University Health Sciences Center, Lubbock, USA

Ratings and Reviews