Receptors in the Evolution and Development of the Brain - 1st Edition - ISBN: 9780128110126

Receptors in the Evolution and Development of the Brain

1st Edition

Matter into Mind

Authors: Richard Fine
Paperback ISBN: 9780128110126
Imprint: Academic Press
Published Date: 1st March 2019
Page Count: 300
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Receptors in the Evolution and Development of the Brain: Matter into Mind presents the key role of receptors and their cognate ligands in wiring the mammalian brain from an evolutionary developmental biology perspective. It examines receptor function in the evolution and development of the nervous system in the large vertebrate brain, and discusses rapid eye movement sleep and apoptosis as mechanisms to destroy miswired neurons. Possible links between trophic deficits and connectional diseases including Alzheimer’s, Parkinson’s, and ALS, are also discussed. This book is extremely useful to those with an interest in the molecular and cellular neurosciences, including those in cognitive and clinical branches of this subject, and anyone interested in how the incredibly complex human brain can build itself.

Key Features

  • Provides an understanding of the key role receptors play in brain development and the selection process necessary to construct a large brain
  • Traces the evolution of receptors, from the most primitive organisms to humans
  • Emphasizes the roles that REM sleep and apoptosis play in this selection via trophic factors and receptors
  • Describes the role that trophic factor-receptor interactions play throughout life and how trophic deficits can lead to connectional diseases, including Alzheimer's, Parkinson's and ALS
  • Provides a potential mechanism whereby neuronal stem cells can cure these diseases


receptor, evolution, brain development, trophic factor, selection, rapid eye movement sleep, apoptosis, connectional neurodegenerative disease, synaptic refinement, stem cells

Table of Contents

1. Introduction
2. Receptors and their Functions
3. The RNA World and First Cells
4. Receptor Functions in Archaea and Bacteria
5. Dictyostelium Discoidium
6. Chaonoflagella
7. Sponges
8. Hydra
9. Cell Biology of Neurons
10. Myelinated Axons
11. Rapid Eye Movement Sleep
12. Apoptosis
13. The Theory
14. Trophic Factors
15. Neuronal Stem Cells
16. Summary and Conclusions


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© Academic Press 2019
Academic Press
Paperback ISBN:

About the Author

Richard Fine

Dr. Richard E. Fine received his Bachelor’s and Ph.D degrees in Biochemistry from University of California at Berkeley and Brandeis University respectively. He then was a postdoctoral fellow in the laboratory of Francis Crick and Sydney Brenner at the Laboratory of Molecular Biology in Cambridge, U.K. During this period he and his colleague, Dennis Bray provided the first evidence for actin in growing neurons. Dr. Fine became an Assistant Professor of Physiology and Biochemistry at Boston University School of Medicine and demonstrated the existence of actin regulatory molecules, tropomyosin and troponin C in growing neurons, and he subsequently became interested in the role of clathrin coated vesicles in endocytic and exocytic processes in neurons and in other tissues. He also isolated and characterized vasopressin receptors, demonstrated for the first time that a large molecular, transferrin, can cross the blood brain barrier. His laboratory used an antisense oligonucleotide for the first time in vivo in the rabbit retina to demonstrate the critical role of kinesin in the transport of synaptic vesicles, neuropeptide containing vesicles and vesicles destined for the plasma membrane. In recent years Dr. Fine’s laboratory has focused on the role of the amyloid beta peptide in Alzheimer’s disease especially in brain capillary endothelium. Also he has recently focused on the role of a mutant protein VPS35, a component of the retromer in Parkinson’s and Alzheimer’s diseases. During his career he has received over $25,000,000 in grant funding, have served on both NIH and VA review panels and authored or co-authored over 100 research papers.

Affiliations and Expertise

Boston University, Cambridge, MA, USA

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