Receptors For Extracellular Matrix - 1st Edition - ISBN: 9780124833654, 9780323141239

Receptors For Extracellular Matrix

1st Edition

Editors: John Mcdonald
eBook ISBN: 9780323141239
Imprint: Academic Press
Published Date: 14th November 1991
Page Count: 344
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Receptors for Extracellular Matrix covers the major receptor families and their potential biological functions. Composed of eight chapters, the book first discusses the structure and function of membrane-associated proteoglycans, focusing on two classes of integral membrane molecules: syndecan and CD44. It then examines the important area of mechanisms of signal transduction from integrin receptors that must mediate the effects of extracellular matrices and other ligands on cell behavior. Multidomain proteins of the extracellular matrix and their role in controlling cellular growth are also considered. This book also discusses the significant research developments in NCAM, the most abundant and widespread of the known vertebrate cell-cell adhesion. The discussion particularly emphasizes the role of posttranslational glycosylation with polysialic acid in the function of the NCAM molecule that undergoes unusual and highly characteristic differences in glycosylation during development. Other chapters deal with the regulation of neural development by the extracellular matrix and the molecular basis of cell adhesion. This book includes discussions on the interaction of adhesion receptors with well-characterized cellular recognition sites and extracellular ligands and cell migration occurring during embryogenesis, gastrulation, neural crest cell migration, neurite extension, lymphocyte migration, and wound healing. The concluding chapters address the wide array of integrin associations, their physiologic relevance and structural aspects, as well as the anchorin CII, a collagen-binding protein of the calpactin-lipocortin family. This book is of great value to cell biologists and researchers.

Table of Contents



Binding of Extracellular Effector Molecules by Cell Surface Proteoglycans

I. Introduction

II. Syndecan, a Mediator of Morphogenesis

III. CD44/Hermes, a Multifunctional Molecule

IV. Phosphatidyl Inositol-Linked Cell Surface Proteoglycans

V. Binding of Effector Molecules to Other Cell Surface Proteoglycans

VI. A Regulatory Role for Cell Surface Proteoglycans in the Binding of Effector Molecules


Macrophage and Inflammatory Cell Matrix Receptors LFA-1, Mac-1, pl50,95 Family

I. Introduction

II. LeuCAM Structure

III. Leukocyte Adherence Deficiency

IV. Β2 Integrins in Leukocyte Adhesion to Endothelium

V. Unique Functions of Members of the LeuCAM Family

VI. LeuCAM Function

VII. Other Leukocyte Integrins


Multidomain Proteins of the Extracellular Matrix and Cellular Growth

I. Introduction

II. Promotion of Growth and Differentiation by the Extracellular Matrix

III. Promotion of Growth and Differentiation by Individual ECM Components

IV. Synergic Actions of ECM Components and Growth Factors

V. Growth Factors Bound and Presented by the ECM

VI. Domains with Growth Factor Activity

VII. Other Functional Sites and Their Possible Involvement in Growth Promotion

VIII. Principles of Growth Factor Action and Growth Control

IX. Receptors for Growth Factor and the Mode of Transmembrane Signal Transduction

X. Second Messengers in the Mitogenic Cascade

XI. Which Receptors Are Involved in Mitogenic Stimulation by ECM Proteins?

XII. Mitogenic Activity of Domains as Integral Parts of Large Structures in Comparison to That of Small Growth Factors


Neural Cell Adhesion Molecule and Polysialic Acid

I. The Biochemistry of NCAM

II. Genetics and Evolution of NCAM

III. NCAM and PSA Expression in Tissues

IV. Biological Function

V. Conclusion


Regulation of Neural Development by the Extracellular Matrix

I. Regulation of Cell Migration and Axon Guidance

II. Regulation of Synaptogenesis

III. Regulation of Cell Proliferation and Differentiation

IV. Regulation of Cell Survival and Differentiation

V. Neural ECM Receptors

VI. Additional ECM Receptors in the Nervous System

VII. Potential Mechanisms of Action


Matrix Receptors in Cell Migration

I. Concepts and Hypotheses: Functions of the Extracellular Matrix in Cell Migration

II. The Molecular Basis of Cell Adhesion

III. Embryonic Cell Migration

IV. Wound Healing

V. Tumor Cell Biology

VI. Future Perspectives


Structures and Functions of VLA Proteins and Related Integrins

I. Introduction

II. Discovery and Early Studies of VLA Proteins and Other Integrins

III. VLA Proteins as Part of the Integrin Family

IV. Physiological Relevance of Integrins

V. Structural Aspects of Integrin α Subunits

VI. Structural Aspects of Integrin β Subunits

VII. Integrin Heterodimers

VIII. Functional Aspects of Integrins/VLA Proteins

IX. Conclusion


Anchorin CII, A Collagen-Binding Protein of the Calpactin-Lipocortin Family

I. Introduction

II. Isolation of Anchorin CII

III. Binding to Collagen In Vitro

IV. Role of Anchorin in Cell-Collagen Interactions

V. Structural Analysis of Anchorin II: Homology to Calpactin and Lipocortin

VI. Biosynthesis, Secretion, and Localization of Anchorin CII on the Cell Surface

VII. Distribution of Anchorin in Tissues

VIII. Role of Anchorin CII in Development

IX. Other Possible Functions of Anchorin CII

X. Endonexin II, the Mammalian Homolog to Anchorin CII with Anticoagulatory and Collagen-Binding Activities




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Academic Press
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About the Editor

John Mcdonald

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