Receptors For Extracellular Matrix

Receptors For Extracellular Matrix

1st Edition - November 14, 1991

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  • Editor: John Mcdonald
  • eBook ISBN: 9780323141239

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Receptors for Extracellular Matrix covers the major receptor families and their potential biological functions. Composed of eight chapters, the book first discusses the structure and function of membrane-associated proteoglycans, focusing on two classes of integral membrane molecules: syndecan and CD44. It then examines the important area of mechanisms of signal transduction from integrin receptors that must mediate the effects of extracellular matrices and other ligands on cell behavior. Multidomain proteins of the extracellular matrix and their role in controlling cellular growth are also considered. This book also discusses the significant research developments in NCAM, the most abundant and widespread of the known vertebrate cell-cell adhesion. The discussion particularly emphasizes the role of posttranslational glycosylation with polysialic acid in the function of the NCAM molecule that undergoes unusual and highly characteristic differences in glycosylation during development. Other chapters deal with the regulation of neural development by the extracellular matrix and the molecular basis of cell adhesion. This book includes discussions on the interaction of adhesion receptors with well-characterized cellular recognition sites and extracellular ligands and cell migration occurring during embryogenesis, gastrulation, neural crest cell migration, neurite extension, lymphocyte migration, and wound healing. The concluding chapters address the wide array of integrin associations, their physiologic relevance and structural aspects, as well as the anchorin CII, a collagen-binding protein of the calpactin-lipocortin family. This book is of great value to cell biologists and researchers.

Table of Contents

  • Contributors


    Binding of Extracellular Effector Molecules by Cell Surface Proteoglycans

    I. Introduction

    II. Syndecan, a Mediator of Morphogenesis

    III. CD44/Hermes, a Multifunctional Molecule

    IV. Phosphatidyl Inositol-Linked Cell Surface Proteoglycans

    V. Binding of Effector Molecules to Other Cell Surface Proteoglycans

    VI. A Regulatory Role for Cell Surface Proteoglycans in the Binding of Effector Molecules


    Macrophage and Inflammatory Cell Matrix Receptors LFA-1, Mac-1, pl50,95 Family

    I. Introduction

    II. LeuCAM Structure

    III. Leukocyte Adherence Deficiency

    IV. Β2 Integrins in Leukocyte Adhesion to Endothelium

    V. Unique Functions of Members of the LeuCAM Family

    VI. LeuCAM Function

    VII. Other Leukocyte Integrins


    Multidomain Proteins of the Extracellular Matrix and Cellular Growth

    I. Introduction

    II. Promotion of Growth and Differentiation by the Extracellular Matrix

    III. Promotion of Growth and Differentiation by Individual ECM Components

    IV. Synergic Actions of ECM Components and Growth Factors

    V. Growth Factors Bound and Presented by the ECM

    VI. Domains with Growth Factor Activity

    VII. Other Functional Sites and Their Possible Involvement in Growth Promotion

    VIII. Principles of Growth Factor Action and Growth Control

    IX. Receptors for Growth Factor and the Mode of Transmembrane Signal Transduction

    X. Second Messengers in the Mitogenic Cascade

    XI. Which Receptors Are Involved in Mitogenic Stimulation by ECM Proteins?

    XII. Mitogenic Activity of Domains as Integral Parts of Large Structures in Comparison to That of Small Growth Factors


    Neural Cell Adhesion Molecule and Polysialic Acid

    I. The Biochemistry of NCAM

    II. Genetics and Evolution of NCAM

    III. NCAM and PSA Expression in Tissues

    IV. Biological Function

    V. Conclusion


    Regulation of Neural Development by the Extracellular Matrix

    I. Regulation of Cell Migration and Axon Guidance

    II. Regulation of Synaptogenesis

    III. Regulation of Cell Proliferation and Differentiation

    IV. Regulation of Cell Survival and Differentiation

    V. Neural ECM Receptors

    VI. Additional ECM Receptors in the Nervous System

    VII. Potential Mechanisms of Action


    Matrix Receptors in Cell Migration

    I. Concepts and Hypotheses: Functions of the Extracellular Matrix in Cell Migration

    II. The Molecular Basis of Cell Adhesion

    III. Embryonic Cell Migration

    IV. Wound Healing

    V. Tumor Cell Biology

    VI. Future Perspectives


    Structures and Functions of VLA Proteins and Related Integrins

    I. Introduction

    II. Discovery and Early Studies of VLA Proteins and Other Integrins

    III. VLA Proteins as Part of the Integrin Family

    IV. Physiological Relevance of Integrins

    V. Structural Aspects of Integrin α Subunits

    VI. Structural Aspects of Integrin β Subunits

    VII. Integrin Heterodimers

    VIII. Functional Aspects of Integrins/VLA Proteins

    IX. Conclusion


    Anchorin CII, A Collagen-Binding Protein of the Calpactin-Lipocortin Family

    I. Introduction

    II. Isolation of Anchorin CII

    III. Binding to Collagen In Vitro

    IV. Role of Anchorin in Cell-Collagen Interactions

    V. Structural Analysis of Anchorin II: Homology to Calpactin and Lipocortin

    VI. Biosynthesis, Secretion, and Localization of Anchorin CII on the Cell Surface

    VII. Distribution of Anchorin in Tissues

    VIII. Role of Anchorin CII in Development

    IX. Other Possible Functions of Anchorin CII

    X. Endonexin II, the Mammalian Homolog to Anchorin CII with Anticoagulatory and Collagen-Binding Activities



Product details

  • No. of pages: 344
  • Language: English
  • Copyright: © Academic Press 1991
  • Published: November 14, 1991
  • Imprint: Academic Press
  • eBook ISBN: 9780323141239

About the Editor

John Mcdonald

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