Recent Highlights in the Discovery and Optimization of Crop Protection Products

Recent Highlights in the Discovery and Optimization of Crop Protection Products

1st Edition - March 24, 2021

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  • Editors: Peter Maienfisch, Ir. Mangelinckx
  • eBook ISBN: 9780128210369
  • Paperback ISBN: 9780128210352

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Recent Highlights in the Discovery and Optimization of Crop Protection Products highlights the most prominent, recent results in the search for safe and effective new crop protection products. With a focus on the design, synthesis, optimization and/or structure-activity relationships of new chemistries targeting insect, disease, weed, nematode, vector and animal parasite control, the book also includes recent developments in crop enhancement chemistries and new approaches to crop protection products. The inclusion of information on testing tools, green chemistry approaches, and the latest discovery tools, like modeling, structure-based design, and testing tools makes this volume complete. Based on key presentations given at the 14th International IUPAC conference on Crop Protection, May 19-24, 2019 in Ghent, Belgium, this book includes the many exciting new discoveries and findings reported. It is designed to inspire additional research and advancement in the field.

Key Features

  • Based on science presented at the 2019 International Union of Pure and Applied Chemistry Conference on Crop Protection
  • Provides real-world perspectives on pesticide and disease control progress
  • Presents scientific developments from an international array of contributing authors


Scientists (chemists, biochemists, biologists, molecular modelers, R&D managers) focused on crop protection. Graduate students in the above

Table of Contents

  • Preface
    Peter Maienfisch and Sven Mangelinckx
    1. Recent innovation in crop protection research
    Peter Maienfisch and Sven Mangelinckx
    2. Status and potential of bioprotection products for crop protection
    Pamela G. Marrone
    3. Research and development of green pesticides in China
    Xusheng Shao, Zhong Li and Xuhong Qian
    4. Agrochemical disease control: The story so far
    Clemens Lamberth, Stefano Rendine and Sarah Sulzer-Mosse
    5. Plant defense priming in the field: a review
    Willem Desmedt, Bartel Vanholme and Tina Kyndt
    6. Reaching beyond crop protection: Synergism between agricultural development and malaria eradication
    Daniel Strickman, Nick Hamon, Thomas S. Churcher, Ellie Sherrard-Smith and Derek W. Willis
    7. Discovery and optimization of a novel insecticide, broflanilide
    T. Nakao, H. Katsuta, M. Nomura, T. Wakita, H. Daido, Y. Kobayashi, A. Kawahara and S. Banba
    8. Studies on a novel insecticide, fluxametamide
    T. Mita, Y. Furukawa, M. Iwasa, T. Kikuchi and M. Komoda
    9. The discovery of isocycloseram: A novel isoxazoline insecticide
    Jérôme Cassayre, Tomas Smejkal, Judith Blythe, Patrik Hoegger, Peter Renold, Thomas Pitterna, C.S. Prasanna, Helmars Smits, Edouard Godineau, Torsten Luksch, Guillaume Berthon, Girish Rawal, Rupesh Patre, Mukul Lal, Mohamed Boussemghoune, Simonetta Masala, Fabien Barreteau, Michael Flaeschel, Juliane Vogt and Myriem El Qacemi
    10. Cyclaniliprole: A novel diamide insecticide
    Masamitsu Tsukamoto, Taku Hamamoto, Masayuki Morita, Kenichi Nakamoto, Akihiro Hisamatsu and Toru Koyanagi
    11. Optimization of mesoionic pyrido[1,2-a]pyrimidinone insecticides and discovery of 3-biaryl analogs controlling Lepidoptera species
    Wenming Zhang, Kenneth A. Hughes, Caleb W. Holyoke Jr., My-Hanh T. Tong, George P. Lahm, Thomas F. Pahutski, James Barry, Daniel Cordova, Robert M. Leighty, Ming Xu, Twyla A. Briddell, Stephen F. McCann, Yewande T. Henry and Yuzhong Chen
    12. Chemistry and biology connected: the development of Inscalis
    Christopher Koradin, Hartwig Schröder, Kazuhiko Oyama and Satoshi Ōmura
    13. Spiropidion discovery: Broad spectrum control of sucking insects and mites for multicrop utility
    M. Muehlebach, J. Schaetzer, A. Buchholz, A.J. Flemming, C.R. Godfrey, E. Godineau, M. Hamer, F. Vock-Hatt, O. Hueter, D.P. Kloer, P. Maienfisch, S. Oliver, F. Perruccio, Thomas Pitterna, C. Popp, R. Senn, R. Slater, Tomas Smejkal, D. Stafford, J. Wenger, L. Wildsmith and W. Zambach
    14. Discovery of oxazosulfyl: A novel broad-spectrum insecticide
    Mai Ito, Yoshihiko Nokura, Masaki Takahashi, Hiroji Yamada and Atsushi Iwata
    15. Synthesis and biological activity of a novel insecticide, benzpyrimoxan
    Eikoh Satoh, Ryota Kasahara, Kosuke Fukatsu, Takao Aoki, Hiroto Harayama, Tetsuya Murata and Akiyuki Suwa
    16. Discovery and optimization of silicon-containing complex II acaricides
    Cong Zhou, Jiagao Cheng, Zhong Li and Peter Maienfisch
    17. Cycloclavine: A natural product with insecticidal potential
    Joachim Dickhaut, Andrea Molt and Johannes Röckl
    18. Photoresponsive pesticidal agents
    Xusheng Shao
    19. Discovery and optimization of novel mosquitocidal compounds for the control of anopheline vectors of malaria
    P. Wege, O. Hueter, M. Hoppé, Peter Maienfisch, R. Nourani and M. Daniels
    20. Antiparasitic dinitrile compounds for fly control in cattle
    Nikolas Huwyler, Vincent L. Salgado, Pascal Bindschaedler, Birgit Gockel, Matthias Pohlman, Sebastian Soergel, Douglas D. Anspaugh, Ralph Paulini, Nancy B. Rankl, James S. Hunter III and Charles Meng
    21. Design, structural derivation, and nematicidal activities of 1,2,3-benzotriazin-4-one derivatives
    Xiaoyong Xu, Xiulei Chen, Gaolei Wang, Jingwei Zhang, Youxin Xiao, Hongfeng Shen, Yaning Chang, Wei Li, Haowu Jia, Ruifeng Zhang and Xiaofeng Cao
    22. ADEPIDYN—the first N-methoxy-substituted carboxamide among the succinate dehydrogenase inhibitors
    Daniel Stierli, Hans Ulrich Haas, Ramya Rajan, Dave Bartlett, Helge Sierotzki, Fredrik Cederbaum, Harald Walter and Clemens Lamberth
    23. Isoflucypram—the next-generation succinate dehydrogenase inhibitor fungicide
    Anika Bartholomaeus, Peter Dahmen, Philippe Desbordes, Bernd Essigmann, Stephanie Gary, Oliver Gutbrod, Jochen Kleemann, Peter Lancashire, Michael Maue, Hans-Georg Schwarz and Helen Tinwell
    24. Discovery and biological profile of inpyrfluxam: A new broad-spectrum succinate dehydrogenase inhibitor fungicide
    So Kiguchi, Takuya Inoue, Yuichi Matsuzaki, Fukumatsu Iwahashi and Hiroshi Sakaguchi
    25. Isofetamid: Discovery and optimization of a novel fungicide
    T. Yoneda, Y. Nakamura, S. Tsukuda, Y. Abe, M. Matsumoto and S. Mitani
    26. Discovery of the trifluoromethyloxadiazoles—a new class of fungicides with a novel mode-of-action
    Christian Winter and Marcus Fehr
    27. The discovery of metyltetraprole: Reconstruction of the quinone outside inhibitor extended pharmacophore to overcome QoI-resistant strains
    Yuichi Matsuzaki, Yuya Yoshimoto, Sadayuki Arimori and Fukumatsu Iwahashi
    28. The discovery of florylpicoxamid, a new picolinamide for disease control
    Kevin G. Meyer, Chenglin Yao, Yu Lu, Karla Bravo-Altamirano, Zachary Buchan, John F. Daeuble, Kyle DeKorver, Jonathan DeLorbe, Ron Heemstra, Jessica Herrick, David Jones, Brian A. Loy, Jared Rigoli, Nick X. Wang, Jeremy Wilmot and David Young
    29. Discovery and validation of pesticide novel target: take pyruvate kinase as an example
    Bin Zhao, Lai Chen, Jingao Dong and Zhijin Fan
    30. Discovery and mode of action of cyclopyrimorate: A new paddy rice herbicide
    Mamiko Shino, Takahiro Hamada, Yoshio Shigematsu, Kangetsu Hirase, Shinichi Banba, Yoshihisa Tsukamoto and Junji Kadotani
    31. Toward a mechanistic understanding of IGPD: A potential herbicide target
    Russell Viner
    32. Isoxazolopyridines—a novel chemical cluster and a new (?) mode of action for dicot weed control
    Thomas Seitz, Ruth Campe and Anna Michrowska-Pianowska
    33. Quinazoline-2,4-dione: A promising scaffold for herbicide discovery
    Ren-Yu Qu, Jia-Xu Nan, Yao-Chao Yan, Hong-Yan Lin, Wen-Chao Yang and Guang-Fu Yang
    34. Tirexorâ —design of a new resistance breaking protoporphyrinogen IX oxidase inhibitor
    Matthias Witschel, Raphael Aponte, Gregory Armel, Peter Bowerman, Thomas Mietzner, Trevor Newton, Aimone Porri, Anja Simon and Thomas Seitz
    35. Rinskor active herbicide—A new environment-friendly tool for weed management in rice and aquatic environments
    Rafael Herrera, Monte R. Weimer, Mauricio Morell, Patrick L. Havens, Giovanna Meregalli, Sabitha Papineni, Laura A. Laughlin and Guomin Shan
    36. Discovery of a novel uracil herbicide by using intermediate derivatization approach
    Jichun Yang, Aiying Guan, Qiao Wu, Dongliang Cui, Hongjuan Ma and Changling Liu
    37. Herbicidal activity and application of 1-(furan-2-yl)methylphosphonates as pyruvate dehydrogenase complex inhibitor against broadleaf weeds
    Hong-Wu He, Yuan Zhou, Hao Peng, Tao Wang, Xiao-song Tan and Jun-Lin Yuan
    38. Pesticide activities evaluation of b -carboline, dihydro-b -carboline, tetrahydro-b -carboline alkaloids, and their derivatives
    Hongjian Song, Jingjing Zhang, Yongqiang Li and Qingmin Wang
    39. Marine natural products and plant virus control
    Ziwen Wang, Aidang Lu and Qingmin Wang
    40. Design, synthesis, and biological evaluation of strigolactone derivatives for crop enhancement applications
    Alain De Mesmaeker, Alexandre Lumbroso, Claudio Screpanti, Katrin Hermann, Mathilde Lachia and Raymonde Fonné-Pfister
    41. Discovery and optimization of novel plant activators through structure-based virtual screening
    Qinjie Shi, Yanxia Shi, Kang Chang, Zheng Xu, Pengfei Li, Zhenjiang Zhao, Weiping Zhu, Honglin Li, BaoJu Li, Xuhong Qian and Yufang Xu

Product details

  • No. of pages: 646
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: March 24, 2021
  • Imprint: Academic Press
  • eBook ISBN: 9780128210369
  • Paperback ISBN: 9780128210352

About the Editors

Peter Maienfisch

Peter Maienfisch is founder and owner of CreInSol MCB, honorary professor at the East China University of Science and Technology, Shanghai, China and lecturer at the University of Basel, Switzerland. Previously he held various management positions in crop protection research and development at Ciba, Novartis and Syngenta, most recently as Research Portfolio Manager Insect Control & Seedcare at Syngenta Crop Protection AG in Switzerland (until April 2020). His track record of innovation and successful introduction of new technologies includes the authorship of more than 200 scientific papers and patents, the invention of Thiamethoxam (Actara®, Cruiser®), one of the leading insecticides worldwide, and major contributions to the discovery of several new active ingredients currently in worldwide development, such as spiropidion, isocycloseram, cyclobutrifluram and a malaria vector control agent. His scientific contributions also led to numerous invitations as speaker and/or co-organizer of many international congresses, including IUPAC Crop Protection congresses.

Affiliations and Expertise

Founder and owner--CreInSol MCB Honorary professor--East China University of Science and Technology Lecturer--University of Basel, Switzerland

Ir. Mangelinckx

Sven Mangelinckx is co-director of the SynBioC Research Group, Ghent University, Belgium. SynBioC is broadly active in the synthesis of medicinal and crop protection compounds, isolation of natural products, modification of bioresources, green chemistry, microreactor technology and chemical biology. He obtained a PhD in chemistry in 2006 at Ghent University. Afterwards, he was a postdoctoral fellow of the Scientific Research Fund of Flanders with a research stay at the RWTH Aachen, Germany and received the Thieme Chemistry Journal Award in 2013. Since 2013, he is professor at the Department of Green Chemistry and Technology, (co-)author of 100 scientific papers, >100 conference abstracts, and (co-)promoter of 16 PhD students. He has been acting as organic chemistry section editor of Molecules, co-chairman of Bioheterocycles 2019 and national chairman of the scientific committee of topic 3 ‘Discovery and Optimization of Crop Protection Products’ of the 14th International IUPAC Congress on Crop Protection.

Affiliations and Expertise

Co-Director--SynBioC Research Group Ghent University, Belgium

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