Recent Highlights in the Discovery and Optimization of Crop Protection Products

1st Edition - March 24, 2021
Editors: Peter Maienfisch, Ir. Sven Mangelinckx
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 1 0 3 5 - 2
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 1 0 3 6 - 9

Recent Highlights in the Discovery and Optimization of Crop Protection Products highlights the most prominent, recent results in the search for safe and effective new crop prot… Read more

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Recent Highlights in the Discovery and Optimization of Crop Protection Products highlights the most prominent, recent results in the search for safe and effective new crop protection products. With a focus on the design, synthesis, optimization and/or structure-activity relationships of new chemistries targeting insect, disease, weed, nematode, vector and animal parasite control, the book also includes recent developments in crop enhancement chemistries and new approaches to crop protection products. The inclusion of information on testing tools, green chemistry approaches, and the latest discovery tools, like modeling, structure-based design, and testing tools makes this volume complete.

Based on key presentations given at the 14th International IUPAC conference on Crop Protection, May 19-24, 2019 in Ghent, Belgium, this book includes the many exciting new discoveries and findings reported. It is designed to inspire additional research and advancement in the field.

Preface
Peter Maienfisch and Sven Mangelinckx

1. Recent innovation in crop protection research
Peter Maienfisch and Sven Mangelinckx

2. Status and potential of bioprotection products for crop protection
Pamela G. Marrone

3. Research and development of green pesticides in China
Xusheng Shao, Zhong Li and Xuhong Qian

4. Agrochemical disease control: The story so far
Clemens Lamberth, Stefano Rendine and Sarah Sulzer-Mosse

5. Plant defense priming in the field: a review
Willem Desmedt, Bartel Vanholme and Tina Kyndt

6. Reaching beyond crop protection: Synergism between agricultural development and malaria eradication
Daniel Strickman, Nick Hamon, Thomas S. Churcher, Ellie Sherrard-Smith and Derek W. Willis

7. Discovery and optimization of a novel insecticide, broflanilide
T. Nakao, H. Katsuta, M. Nomura, T. Wakita, H. Daido, Y. Kobayashi, A. Kawahara and S. Banba

8. Studies on a novel insecticide, fluxametamide
T. Mita, Y. Furukawa, M. Iwasa, T. Kikuchi and M. Komoda

9. The discovery of isocycloseram: A novel isoxazoline insecticide
Jérôme Cassayre, Tomas Smejkal, Judith Blythe, Patrik Hoegger, Peter Renold, Thomas Pitterna, C.S. Prasanna, Helmars Smits, Edouard Godineau, Torsten Luksch, Guillaume Berthon, Girish Rawal, Rupesh Patre, Mukul Lal, Mohamed Boussemghoune, Simonetta Masala, Fabien Barreteau, Michael Flaeschel, Juliane Vogt and Myriem El Qacemi

10. Cyclaniliprole: A novel diamide insecticide
Masamitsu Tsukamoto, Taku Hamamoto, Masayuki Morita, Kenichi Nakamoto, Akihiro Hisamatsu and Toru Koyanagi

11. Optimization of mesoionic pyrido[1,2-a]pyrimidinone insecticides and discovery of 3-biaryl analogs controlling Lepidoptera species
Wenming Zhang, Kenneth A. Hughes, Caleb W. Holyoke Jr., My-Hanh T. Tong, George P. Lahm, Thomas F. Pahutski, James Barry, Daniel Cordova, Robert M. Leighty, Ming Xu, Twyla A. Briddell, Stephen F. McCann, Yewande T. Henry and Yuzhong Chen

12. Chemistry and biology connected: the development of Inscalis
Christopher Koradin, Hartwig Schröder, Kazuhiko Oyama and Satoshi Ōmura

13. Spiropidion discovery: Broad spectrum control of sucking insects and mites for multicrop utility
M. Muehlebach, J. Schaetzer, A. Buchholz, A.J. Flemming, C.R. Godfrey, E. Godineau, M. Hamer, F. Vock-Hatt, O. Hueter, D.P. Kloer, P. Maienfisch, S. Oliver, F. Perruccio, Thomas Pitterna, C. Popp, R. Senn, R. Slater, Tomas Smejkal, D. Stafford, J. Wenger, L. Wildsmith and W. Zambach

14. Discovery of oxazosulfyl: A novel broad-spectrum insecticide
Mai Ito, Yoshihiko Nokura, Masaki Takahashi, Hiroji Yamada and Atsushi Iwata

15. Synthesis and biological activity of a novel insecticide, benzpyrimoxan
Eikoh Satoh, Ryota Kasahara, Kosuke Fukatsu, Takao Aoki, Hiroto Harayama, Tetsuya Murata and Akiyuki Suwa

16. Discovery and optimization of silicon-containing complex II acaricides
Cong Zhou, Jiagao Cheng, Zhong Li and Peter Maienfisch

17. Cycloclavine: A natural product with insecticidal potential
Joachim Dickhaut, Andrea Molt and Johannes Röckl

18. Photoresponsive pesticidal agents
Xusheng Shao

19. Discovery and optimization of novel mosquitocidal compounds for the control of anopheline vectors of malaria
P. Wege, O. Hueter, M. Hoppé, Peter Maienfisch, R. Nourani and M. Daniels

20. Antiparasitic dinitrile compounds for fly control in cattle
Nikolas Huwyler, Vincent L. Salgado, Pascal Bindschaedler, Birgit Gockel, Matthias Pohlman, Sebastian Soergel, Douglas D. Anspaugh, Ralph Paulini, Nancy B. Rankl, James S. Hunter III and Charles Meng

21. Design, structural derivation, and nematicidal activities of 1,2,3-benzotriazin-4-one derivatives
Xiaoyong Xu, Xiulei Chen, Gaolei Wang, Jingwei Zhang, Youxin Xiao, Hongfeng Shen, Yaning Chang, Wei Li, Haowu Jia, Ruifeng Zhang and Xiaofeng Cao

22. ADEPIDYN—the first N-methoxy-substituted carboxamide among the succinate dehydrogenase inhibitors
Daniel Stierli, Hans Ulrich Haas, Ramya Rajan, Dave Bartlett, Helge Sierotzki, Fredrik Cederbaum, Harald Walter and Clemens Lamberth

23. Isoflucypram—the next-generation succinate dehydrogenase inhibitor fungicide
Anika Bartholomaeus, Peter Dahmen, Philippe Desbordes, Bernd Essigmann, Stephanie Gary, Oliver Gutbrod, Jochen Kleemann, Peter Lancashire, Michael Maue, Hans-Georg Schwarz and Helen Tinwell

24. Discovery and biological profile of inpyrfluxam: A new broad-spectrum succinate dehydrogenase inhibitor fungicide
So Kiguchi, Takuya Inoue, Yuichi Matsuzaki, Fukumatsu Iwahashi and Hiroshi Sakaguchi

25. Isofetamid: Discovery and optimization of a novel fungicide
T. Yoneda, Y. Nakamura, S. Tsukuda, Y. Abe, M. Matsumoto and S. Mitani

26. Discovery of the trifluoromethyloxadiazoles—a new class of fungicides with a novel mode-of-action
Christian Winter and Marcus Fehr

27. The discovery of metyltetraprole: Reconstruction of the quinone outside inhibitor extended pharmacophore to overcome QoI-resistant strains
Yuichi Matsuzaki, Yuya Yoshimoto, Sadayuki Arimori and Fukumatsu Iwahashi

28. The discovery of florylpicoxamid, a new picolinamide for disease control
Kevin G. Meyer, Chenglin Yao, Yu Lu, Karla Bravo-Altamirano, Zachary Buchan, John F. Daeuble, Kyle DeKorver, Jonathan DeLorbe, Ron Heemstra, Jessica Herrick, David Jones, Brian A. Loy, Jared Rigoli, Nick X. Wang, Jeremy Wilmot and David Young

29. Discovery and validation of pesticide novel target: take pyruvate kinase as an example
Bin Zhao, Lai Chen, Jingao Dong and Zhijin Fan

30. Discovery and mode of action of cyclopyrimorate: A new paddy rice herbicide
Mamiko Shino, Takahiro Hamada, Yoshio Shigematsu, Kangetsu Hirase, Shinichi Banba, Yoshihisa Tsukamoto and Junji Kadotani

31. Toward a mechanistic understanding of IGPD: A potential herbicide target
Russell Viner

32. Isoxazolopyridines—a novel chemical cluster and a new (?) mode of action for dicot weed control
Thomas Seitz, Ruth Campe and Anna Michrowska-Pianowska

33. Quinazoline-2,4-dione: A promising scaffold for herbicide discovery
Ren-Yu Qu, Jia-Xu Nan, Yao-Chao Yan, Hong-Yan Lin, Wen-Chao Yang and Guang-Fu Yang

34. Tirexorâ —design of a new resistance breaking protoporphyrinogen IX oxidase inhibitor
Matthias Witschel, Raphael Aponte, Gregory Armel, Peter Bowerman, Thomas Mietzner, Trevor Newton, Aimone Porri, Anja Simon and Thomas Seitz

35. Rinskor active herbicide—A new environment-friendly tool for weed management in rice and aquatic environments
Rafael Herrera, Monte R. Weimer, Mauricio Morell, Patrick L. Havens, Giovanna Meregalli, Sabitha Papineni, Laura A. Laughlin and Guomin Shan

36. Discovery of a novel uracil herbicide by using intermediate derivatization approach
Jichun Yang, Aiying Guan, Qiao Wu, Dongliang Cui, Hongjuan Ma and Changling Liu

37. Herbicidal activity and application of 1-(furan-2-yl)methylphosphonates as pyruvate dehydrogenase complex inhibitor against broadleaf weeds
Hong-Wu He, Yuan Zhou, Hao Peng, Tao Wang, Xiao-song Tan and Jun-Lin Yuan

38. Pesticide activities evaluation of b -carboline, dihydro-b -carboline, tetrahydro-b -carboline alkaloids, and their derivatives
Hongjian Song, Jingjing Zhang, Yongqiang Li and Qingmin Wang

39. Marine natural products and plant virus control
Ziwen Wang, Aidang Lu and Qingmin Wang

40. Design, synthesis, and biological evaluation of strigolactone derivatives for crop enhancement applications
Alain De Mesmaeker, Alexandre Lumbroso, Claudio Screpanti, Katrin Hermann, Mathilde Lachia and Raymonde Fonné-Pfister

41. Discovery and optimization of novel plant activators through structure-based virtual screening
Qinjie Shi, Yanxia Shi, Kang Chang, Zheng Xu, Pengfei Li, Zhenjiang Zhao, Weiping Zhu, Honglin Li, BaoJu Li, Xuhong Qian and Yufang Xu

Peter Maienfisch

Peter Maienfisch is founder and owner of CreInSol MCB, honorary professor at the East China University of Science and Technology, Shanghai, China and lecturer at the University of Basel, Switzerland. Previously he held various management positions in crop protection research and development at Ciba, Novartis and Syngenta, most recently as Research Portfolio Manager Insect Control & Seedcare at Syngenta Crop Protection AG in Switzerland (until April 2020). His track record of innovation and successful introduction of new technologies includes the authorship of more than 200 scientific papers and patents, the invention of Thiamethoxam (Actara®, Cruiser®), one of the leading insecticides worldwide, and major contributions to the discovery of several new active ingredients currently in worldwide development, such as spiropidion, isocycloseram, cyclobutrifluram and a malaria vector control agent. His scientific contributions also led to numerous invitations as speaker and/or co-organizer of many international congresses, including IUPAC Crop Protection congresses.

Affiliations and expertise

Founder and owner--CreInSol MCB Honorary professor--East China University of Science and Technology Lecturer--University of Basel, Switzerland

Ir. Sven Mangelinckx

Sven Mangelinckx is co-director of the SynBioC Research Group, Ghent University, Belgium. SynBioC is broadly active in the synthesis of medicinal and crop protection compounds, isolation of natural products, modification of bioresources, green chemistry, microreactor technology and chemical biology. He obtained a PhD in chemistry in 2006 at Ghent University. Afterwards, he was a postdoctoral fellow of the Scientific Research Fund of Flanders with a research stay at the RWTH Aachen, Germany and received the Thieme Chemistry Journal Award in 2013. Since 2013, he is professor at the Department of Green Chemistry and Technology, (co-)author of 100 scientific papers, >100 conference abstracts, and (co-)promoter of 16 PhD students. He has been acting as organic chemistry section editor of Molecules, co-chairman of Bioheterocycles 2019 and national chairman of the scientific committee of topic 3 ‘Discovery and Optimization of Crop Protection Products’ of the 14th International IUPAC Congress on Crop Protection.

Affiliations and expertise

Co-Director--SynBioC Research Group Ghent University, Belgium