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Recent Highlights in the Discovery and Optimization of Crop Protection Products - 1st Edition - ISBN: 9780128210352

Recent Highlights in the Discovery and Optimization of Crop Protection Products

1st Edition

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Editors: Peter Maienfisch Ir. Mangelinckx
Paperback ISBN: 9780128210352
Imprint: Academic Press
Published Date: 31st January 2021
Page Count: 600
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Description

Recent Highlights in the Discovery and Optimization of Crop Protection Products highlights the most prominent, recent results in the search for safe and effective new crop protection products. With a focus on the design, synthesis, optimization and/or structure-activity relationships of new chemistries targeting insect, disease, weed, nematode, vector and animal parasite control, the book also includes recent developments in crop enhancement chemistries and new approaches to crop protection products. The inclusion of information on testing tools, green chemistry approaches, and the latest discovery tools, like modeling, structure-based design, and testing tools makes this volume complete.

Based on key presentations given at the 14th International IUPAC conference on Crop Protection, May 19-24, 2019 in Ghent, Belgium, this book includes the many exciting new discoveries and findings reported. It is designed to inspire additional research and advancement in the field.

Key Features

  • Based on science presented at the 2019 International Union of Pure and Applied Chemistry Conference on Crop Protection
  • Provides real-world perspectives on pesticide and disease control progress
  • Presents scientific developments from an international array of contributing authors

Readership

Scientists (chemists, biochemists, biologists, molecular modelers, R&D managers) focused on crop protection. Graduate students in the above

Table of Contents

  1. Current trends and challenges in Crop Protection
    2. New chemistries targeting insect control
    3. Discovery and optimization of a novel insecticide, broflanilide
    4. Studies on a novel insecticide, fluxametamide
    5. The discovery of Isocycloseram: A novel isoxazoline insecticide
    6. Discovery, synthesis and structure-activity relationship of tetraniliprole (VayegoTM), a novel diamide insecticide
    7. Cyclaniliprole: A novel diamide insecticide
    8. Optimization of mesoionic pyrido[1,2-a] pyrimidinone insecticides & discovery of 3-biaryl analogs controlling lepidoptera species
    9. MNKE as a natural solution against insecticide-resistant pests
    10. Biology and Chemistry connected: The Development of Inscalis®
    11. Spiropidion discovery: road spectrum control of sucking pests and mites for multi-crop utility
    12. Synthesis and biological activity of a novel insecticide, benzpyrimoxan
    13. Design, synthesis and acaricidal activities of Cyflumetofen analogues based on carbon-silicon isosteric replacement
    14. Cycloclavine: A natural product with insecticidal potential
    15. Design, Synthesis of OfHex1 Inhibitors as Novel Pesticidal Leads
    16. New chemistries targeting disease control
    17. Discovery of ADEPIDYNTM
    18. Isoflucypram – A new succinate dehydrogenase inhibitor with unique structural features and performance
    19. Discovery of inpyrfluxam
    20. Isoflucypram – An innovative disease management tool with an unprecedented biological performance
    21. Chiral antifungal amides of 2-(2-oxazolinyl) aniline for the discovery of novel SDHIs
    22. Discovery of chiral antifungal ingredients with drimane as a new scaffold
    23. Discovery and biological profile of metyltetraprole
    24. Discovery of florylpicoxamid, a new picolinamide for disease control
    25. Revysol®: The new broad-spectrum fungicide of BASF SE
    26. Synthesis and fungicidal activity of novel types of oxysterol-binding protein inhibitors
    27. Azole Carbinols as Fungicides
    28. Discovery of Pyruvate Kinase as a Fungicide Target by DARTS
    29. New chemistries targeting crop enhancement and animal parasite, nematode and vector control
    30. Malaria Eradication, Agricultural Innovation and the ZERO by 40 Initiative
    31. Discovery and optimisation of novel compounds for the control of anopheline vectors of malaria
    32. Monoterpenoid esters as long-lasting spatial mosquito repellents
    33. Synergies between insecticide and parasiticide research: An evolving success story
    34. Antiparasitic dinitrile compounds for fly control in cattle
    35. Development of highly efficient plant virus disease prevention and control drug candidate NK0209 and NK0333
    36. Discovery of novel antiviral agents based on marine natural products
    37. Design, synthesis and biological evaluation of Strigolactones derivatives for Crop Enhancement applications
    38. Use of synthetic plant defense elicitors as reduced-risk pesticide alternatives
    39. Discovery and optimization of 3(2H)-pyridazinone derivatives as novel plant activators
    40. CEDROZ®, new terpene nematicide against root knot nematode on Solanaceae and cucurbits
    41. Design, structural derivation and nematicidal activities of 1,2,3-Benzotriazin-4-one derivatives
    42. A novel class of priming agents with activity against fungi and nematodes
    43. Mulching efficacy and effect on soil microbial health of a sprayable, biodegradable polymeric mulch
    44. New chemistries targeting weed control
    45. The discovery of aryl pyrrolidinone anilides: A new mode-of-action herbicide class that inhibits dihydroorotate dehydrogenase
    46. Luximo™ herbicide – Rediscovering a dormant molecule
    47. Discovery and mode of action of cyclopyrimorate, a new paddy rice herbicide
    48. A new herbicide mode of action from a bioherbcicide component, spiceostatin c
    49. Resistance-gene directed discovery of a natural product herbicide with a new mode of action
    50. Towards a Mechanistic Understanding of IGPD – A Potential Herbicide Target
    51. Isoxazolopyridines - A novel chemical cluster and a new mode of action for dicot weed control
    52. Discovery of New 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors as Potential Herbicides
    53. TirexorTM – Design of a new resistance breaking PPO-inhibitor
    54. Rinskor™ active herbicide, a new environmentally friendly tool for weed management in rice and aquatic environments
    55. Investigating c-h activation chemistry of n-phenyl azoles: discovery of a new class of herbicides
    56. Discovery of Novel Uracil herbicide by using Intermediate Derivatization Approach
    57. New approaches to crop protection products: discovery tools, green chemistry
    58. The use of green chemistry principles in the responsible design of crop protection processes and products
    59. Process route design of macrocyclic picolinamide fungicide X507
    60. New isothiazole inhibitors of protein biosynthesis: Towards the development of modern agchem products
    61. New approach to a bacterial causative crop disease and weed controls, using N-3-hydroxyoctanoyl-l- homoserine lactone, a tropolone biosynthetic activator for burkholderia plantarii
    62. COMPASS - A comprehensive model for pesticide activity in soils designed to guide the development and sustainable use of pesticides
    63. Nitrogen fertilization: A determining factor for efficiency of plant defense elicitors?
    64. Natural products: Most effective tool for creating green crop protection products
    65. Natural products: A source and inspiration for crop protection lead generation
    66. Photochromic insecticides for insect behavior modulation
    67. Exploring the molecular recognition properties of insect nicotinic acetylcholine receptors competitive modulators through multiscale molecular modeling
    68. A computational predictive approach for the discovery and optimization of new crop protection compounds
    69. The agrochemical discovery portal: New computational platform for efficiently study pesticide and target interaction

Details

No. of pages:
600
Language:
English
Copyright:
© Academic Press 2021
Published:
31st January 2021
Imprint:
Academic Press
Paperback ISBN:
9780128210352

About the Editors

Peter Maienfisch

Dr. Peter Maienfisch is a Research Portfolio Manager / Insect Control and Seedcare at Syngenta, including Ciab Geigy and Novartis, and has been active in the field of crop protection for thirty years. He has more than 160 publications, is a member of the editorial board of CHIMIA. Of all his remarkable achievements in crop protection, it is particularly noteworthy that he is the inventor of thiamethoxam, a neonicotinoid insecticide.

Affiliations and Expertise

Research Portfolio Manager / Insect Control and Seedcare, Syngenta

Ir. Mangelinckx

Prof. Dr. ir. Sven Mangelinckx received his master’s diploma in bioscience engineering - chemistry from Ghent University, Belgium, and obtained his PhD at Ghent University. From October 2013 to the present he has served as an Associate Professor at Ghent University. Prof. Mangelinckx is an IUPAC 2019 Topic 3 R Lead organizer who won the Thieme Chemistry Journal Award in 2013. His main research interests include: chemistry of non-proteinogenic amino acids with focus on conformationally constrained β-amino acids, chemistry of small-membered azaheterocycles, chemistry of natural products, isolation and synthesis of bioactive natural products, and stereoselective synthesis. He is a participant in the Scientific Research Network of the Research Foundation and has served as reference for various international journals.

Affiliations and Expertise

Associate Professor, Department of Green Chemistry and Technology, Research Group, SynBioC

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