Recent Advances in Steroid Biochemistry

Recent Advances in Steroid Biochemistry

1st Edition - October 27, 1975

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  • Editor: J. R. Pasqualini
  • eBook ISBN: 9781483140148

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Description

Recent Advances in Steroid Biochemistry contains the proceedings of the Second International Symposium of the Journal of Steroid Biochemistry. Separating 38 papers as chapters, this book discusses the partial purification of steroid-receptor complexes; enzymatic techniques in steroid assay; mass fragmentography of steroid hormones; biological consequences of 18-hydroxylation; and steroidogenesis in adrenal cells. This text also explores the regulation of steroidogenesis in testis; androgen binding proteins in different testis compartments; nuclear acceptor sites for glucocorticoid receptors; estrogen receptors in the pancreas; and molecular mechanisms of steroid hormone action.

Table of Contents


  • Front Cover

    Recent Advances in Steroid Biochemistry

    Copyright Page

    Chapter 1. Partial Purification of Steroid-Receptor Complexes by DNA-Cellulose Chromatography and Isoelectric Focusing

    Introduction

    Experimental

    Results and Discussion

    References

    Chapter 2. Enzymatic Techniques in Steroid Assay

    Introduction

    Experimental

    Method

    Results

    Discussion

    References

    Chapter 3. Mass Fragmentography of Steroid Hormones

    Introduction

    Experimental

    Results and Discussion

    Conclusions

    References

    Discussion

    Chapter 4. Separation and Computerized Gas Chromatography-Mass Spectrometry of Unconjugated Neutral Steroids in Plasma

    Introduction

    Experimental

    Results

    Discussion

    References

    Chapter 5. Steroids as Haptens: Optimal Design of Antigens for the Formation of Antibodies to Steroid Hormones

    Definition of the Problem and Rationale of Approach

    General Methods

    Properties of Antisera to Gonadal Steroids in Relation to Structure of the Antigenic Conjugate

    Concluding Remarks

    References

    Chapter 6. Some Aspects of the Use of 125i-Labelled Ligands for Steroid Radioimmunoassay

    Introduction

    Experimental

    Results

    Discussion

    References

    Chapter 7. Testosterone Binding Capacity in Relation to the Production and Metabolism of Testosterone in Dogs, Experiences of A New Method

    Introduction

    Materials and Methods

    Results

    Discussion

    References

    Chapter 8. Simultaneous Estimation of Testosterone, Progesterone and Androstenedione by Gas Chromatography-Mass Spectrometry with A Single Ion Detection Correlation with Radioimmunoassay

    Introduction

    Discussion

    References

    General Discussion

    Chapter 9. The Preparation and use of Purified and Unpurified Dispersed Adrenal Cells and a Study of the Relationship of Their Camp and Steroid Output

    Introduction

    Experimental and Results

    Discussion

    Appendix

    References

    Chapter 10. Biological Consequences of 18-Hydroxylation

    Introduction

    Experimental

    Results

    Discussion

    References

    Chapter 11. Multifactorial Regulation of the Final Steps of Aldosterone Biosynthesis in the Rat

    Stimulators of An Early Biosynthetic Step

    Variable Steroidogenic Response to Stimulators

    Alterations in the Activity of Enzymes Involved in the Final Steps of Aldosterone Biosynthesis

    Renin-Angiotensin

    Potassium

    Serotonin

    Pituitary Gland and ACTH

    Conclusions

    References

    Discussion

    Chapter 12. Some Comparative Studies in Adrenocortical Steroidogenesis: An Interpretation of the Functional Homologies of the Mammalian and Non-Mammalian Adrenal Cortex

    Introduction

    Materials and Methods

    Results

    Discussion

    References

    Chapter 13. Steroidogenesis in Adrenal Cells

    Introduction

    Results and Discussion

    References

    Discussion

    Chapter 14. Stimulation Factors for Cholesterol Side-Chain Cleavage in the Corpus Luteum and Adrenal Gland

    Introduction

    Methods

    Results

    Discussion

    References

    Chapter 15. In Vitro Study On Corticosterone Cytochrome P-450 Binding in Relation to the Regulation of Corticosterone Metabolism

    Introduction

    Materials and Methods

    Results

    Discussion

    References

    General Discussion

    Chapter 16. Superfusion of Rat Testes With Mixtures of Labeled Testosterone and Androstenedione

    Introduction

    Experimental

    Results

    Discussion

    References

    Chapter 17. Regulation of Steroidogenesis in Testis

    Introduction

    Experimental

    Results

    Discussion

    References

    Chapter 18. Androgen Binding Proteins in Different Testis Compartments

    Preparation of Samples

    Sertoli Cell Production of ABP

    Regulation of ABP Production

    Androgens and Spermatogenesis

    References

    Chapter 19. Sexual Differentiation of Hepatic Steroid Metabolism in the Rat

    Introduction

    Experimental

    Results and Discussion

    References

    Discussion

    Chapter 20. Relation of Structure and Biological Action of Gonadotrophins

    Introduction

    References

    Discussion

    Chapter 21. ACTH and Sulfatase Activity

    Introduction

    References

    Steroid Nomenclature

    Results

    Discussion

    References

    Chapter 22. New Results on Oestrogen Glucuronyltransferase

    Introduction

    Conclusions

    References

    General Discussion

    Chapter 23. Effects of Estrogens on Uterine Poly (A)-Rich RNA

    Introduction

    Experimental

    Results

    Discussion

    References

    Chapter 24. In Vitro Stimulation of Nucleolar and Nucleoplasmic RNA Polymerases in Calf Uterus

    Introduction

    Materials and Methods

    Results

    References

    Discussion

    Chapter 25. Hormonal Regulation of Uterine Contractility: the Role of the Adenylate Cyclase System

    Introduction

    Materials and Methods

    Results

    Discussion

    References

    Chapter 26. A Specific Testosterone Receptor in the Cytosol of Rat Anterior Hypophysis

    Introduction

    Materials and Methods

    Results

    Discussion

    References

    Chapter 27. Interaction of Aldosterone and Corticosterone with Cell Nuclei of Target Organs Under Different Functional States

    Introduction

    Experimental

    Results

    Discussion

    References

    Chapter 28. Interactions of ACTH With Its Adrenal Receptors: Specific Binding of Acth1–24, Its O-Nitrophenyl Sulfenyl Derivative and ACTH

    Experimental Procedure

    Discussion

    References

    Chapter 29. Nuclear Acceptor Sites for Glucocorticoid Receptors

    Introduction

    Results and Discussion

    References

    Discussion

    Chapter 30. Testosterone Metabolism: A Necessary Step for Activity?

    Introduction

    Materials and Methods

    Results

    Discussion

    References

    Chapter 31. Investigations of Androgen-Prostatic Tissue Relationships in Superfusion Experiments Using Steroid Concentrations Approaching Those Found In Vivo

    References

    Discussion

    Chapter 32. High Affinity Binding of Oestradiol by Rat Testis Interstitial Tissue and by Several Other Tissues of the Male Rat

    Introduction

    Methods

    Results

    Discussion

    References

    Chapter 33. Interaction Between Oestrogens and Neurotransmitters at the Hypophysial-Hypothalamic Level

    Introduction

    Experimental

    Results

    Discussion

    References

    Chapter 34. Estrogen Receptors in the Pancreas

    Introduction

    Experimental

    Results

    Discussion

    References

    Chapter 35. Steroid Hormone Receptors in Fetal Guinea-Pig Kidney

    Introduction

    Experimental

    Results

    Discussion

    References

    Chapter 36. Hormone-Induced Transformation of Receptor Proteins

    Discussion

    Chapter 37. Molecular Mechanisms of Steroid Hormone Action

    Introduction

    Results

    Discussion

    References

    Chapter 38. Influence of Ouabain on Sodium Transport by Aldosterone-Stimulated Amphibian Epithelia

    Introduction

    References

    General Discussion

    Publisher's Announcement


Product details

  • No. of pages: 302
  • Language: English
  • Copyright: © Pergamon 1975
  • Published: October 27, 1975
  • Imprint: Pergamon
  • eBook ISBN: 9781483140148

About the Editor

J. R. Pasqualini

Affiliations and Expertise

CNRS Steroid Hormone Research Unit, Foundation for Hormone Research, 26 Boulevard Brune, 75014 Paris, France

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