Recent Advances in Parkinsons Disease, Volume 184

1st Edition

Part II: Translational and Clinical Research

Serial Volume Editors: Anders Bjorklund Angela Cenci-Nilsson
Hardcover ISBN: 9780444537508
eBook ISBN: 9780444537515
Imprint: Elsevier Science
Published Date: 1st October 2010
Page Count: 368
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Table of Contents

Section I: Animal models of PD

  1. What have we learned from Drosophila Models of Parkinson's Disease? - Ming Guo
  2. Neurotoxic in vivo models of Parkinson’s disease: recent advances - Timothy Greenamyre & Jason R. Cannon
  3. Behavioural analysis of motor and non-motor symptoms in rodent models of Parkinson’s disease - Stephen B. Dunnett & Mariah Lelos
  4. Genetic mouse models of Parkinson’s disease: the state of the art - Marie-Francoise Chesselet & Iddo Magen
  5. Viral vector mediated overexpression of a-synuclein as a progressive model of Parkinson’s disease - Anders Bjorklund, Ayse Ulusoy, Mickael Decressac, Deniz Kirik
  6. Modelling inflammatory pathogenesis of Parkinson's Disease - Malu Tansey & Christopher J. Barnum
  7. The MPTP-lesioned non-human primate models of Parkinson’s disease. Past, present and future - Susan Fox & Jonathan Brotchie
  8. Section II: Exploring PD with brain imaging

  9. Abnormal Metabolic Brain Networks in Parkinson’s Disease: From Blackboard to Bedside - David Eidelberg & Chris C. Tang
  10. Imaging the Nigrostriatal System to Monitor Disease Progression and Treatment-Induced Complications - Jon Stoessl & Renju Kuriakose
  11. Brain imaging after neural transplantation - Paola Piccini & Marios Politis
  12. Imaging non-motor aspects of Parkinson’s disease - David Brooks & Nicola Pavese
  13. Section III: Frontiers in PD treatment

  14. Gene therapy for dopamine replacement - Deniz Kirik & Tomas Björklund, Erik Ahlm Cederfjäll
  15. Neurotrophic Factor Therapy for Parkinson’s disease - Jeffrey Kordower, Rangasamy Suresh Babu, Katherine Soderstrom, Roy A.E. Bakay
  16. Neural grafting in Parkin

Description

This second volume follows on from Part I by reviewing the variety of animal models of PD current available (from drosophila to rodents to non-human primate species) and their specific contributions to PD research. This is followed by comprehensive coverage of functional neuroimaging studies that explore different pathophysiological questions and evaluate treatment outcome in PD patients. Different areas of experimental therapeutics and outstanding challenges to PD treatment are presented in a concluding group of articles.

Key Features

  • Complete overview of hot topics and approaches to current PD research, from molecules, to brain circuits, to clinical and therapeutic applications
  • Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research
  • All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Readership

Neuroscientists, psychologists, neurologists


Details

No. of pages:
368
Language:
English
Copyright:
© Elsevier Science 2010
Published:
Imprint:
Elsevier Science
eBook ISBN:
9780444537515
Hardcover ISBN:
9780444537508

Reviews

This second volume follows on from Part I by reviewing the variety of animal models of PD current available (from drosophila to rodents to non-human primate species) and their specific contributions to PD research. This is followed by comprehensive coverage of functional neuroimaging studies that explore different pathophysiological questions and evaluate treatment outcome in PD patients. Different areas of experimental therapeutics and outstanding challenges to PD treatment are presented in a concluding group of articles.


About the Serial Volume Editors

Anders Bjorklund Serial Volume Editor

As a neuroanatomist and developmental neurobiologist, during the 1970s Björklund’s lab originated reliable methods for transplantation of embryonic tissues into brain that pioneered practical cell transplantation in the central nervous system, providing the basis for technologies that are now used by laboratories world-wide. In parallel, work in the field has progressed from basic anatomical and developmental studies in experimental animals, via applications for assessing cell replacement and repair using primary and stem cells in the damaged brain, and now underpinning the majority of methods in development for cell therapy in patients. His laboratory continues to analyse the fundamental neurobiology and principles of cell transplantation, regeneration and integration in the CNS, as well as originating the first trials of effective clinical cell transplantation (for Parkinson’s disease) in patients

Affiliations and Expertise

Lund University, Lund, Sweden

Angela Cenci-Nilsson Serial Volume Editor