Description

This second volume follows on from Part I by reviewing the variety of animal models of PD current available (from drosophila to rodents to non-human primate species) and their specific contributions to PD research. This is followed by comprehensive coverage of functional neuroimaging studies that explore different pathophysiological questions and evaluate treatment outcome in PD patients. Different areas of experimental therapeutics and outstanding challenges to PD treatment are presented in a concluding group of articles.

Key Features

  • Complete overview of hot topics and approaches to current PD research, from molecules, to brain circuits, to clinical and therapeutic applications
  • Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research
  • All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Readership

Neuroscientists, psychologists, neurologists

Table of Contents

Section I: Animal models of PD

  1. What have we learned from Drosophila Models of Parkinson's Disease? - Ming Guo
  2. Neurotoxic in vivo models of Parkinson’s disease: recent advances - Timothy Greenamyre & Jason R. Cannon
  3. Behavioural analysis of motor and non-motor symptoms in rodent models of Parkinson’s disease - Stephen B. Dunnett & Mariah Lelos
  4. Genetic mouse models of Parkinson’s disease: the state of the art - Marie-Francoise Chesselet & Iddo Magen
  5. Viral vector mediated overexpression of a-synuclein as a progressive model of Parkinson’s disease - Anders Bjorklund, Ayse Ulusoy, Mickael Decressac, Deniz Kirik
  6. Modelling inflammatory pathogenesis of Parkinson's Disease - Malu Tansey & Christopher J. Barnum
  7. The MPTP-lesioned non-human primate models of Parkinson’s disease. Past, present and future - Susan Fox & Jonathan Brotchie
  8. Section II: Exploring PD with brain imaging

  9. Abnormal Metabolic Brain Networks in Parkinson’s Disease: From Blackboard to Bedside - David Eidelberg & Chris C. Tang
  10. Imaging the Nigrostriatal System to Monitor Disease Progression and Treatment-Induced Complications - Jon Stoessl & Renju Kuriakose
  11. Brain imaging after neural transplantation - Paola Piccini & Marios Politis
  12. Imaging non-motor aspects of Parkinson’s disease - David Brooks & Nicola Pavese
  13. Section III: Frontiers in PD treatment

  14. Gene therapy for dopamine replacement - Deniz Kirik & Tomas Björklund, Erik Ahlm Cederfjäll
  15. Neurotrophic Factor Therapy for Parkinson’s disease - Jeffrey Kordower, Rangasamy Suresh Babu, Katherine Soderstrom, Roy A.E. Bakay
  16. Neural grafting in Parkin

Details

No. of pages:
368
Language:
English
Copyright:
© 2010
Published:
Imprint:
Elsevier Science
Print ISBN:
9780444537508
Electronic ISBN:
9780444537515