Recent Advances in Parkinsons Disease

Recent Advances in Parkinsons Disease

Part I: Basic Research

1st Edition - August 20, 2010
There is a Newer Edition Available
  • Editors: Anders Bjorklund, Angela Cenci-Nilsson
  • eBook ISBN: 9780444536242
  • Hardcover ISBN: 9780444536143

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Description

This first volume starts with an overview on current perspectives in genetic research and on the molecular mechanisms of neurodegeneration. This is followed by a selection of hot topics in pathophysiological research, from molecular studies to system-level investigations based on in vivo electrophysiological recordings and neurocomputational methods.

Key Features

  • Complete overview of hot topics and approaches to current PD research, from molecules, to brain circuits, to clinical and therapeutic applications
  • Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research
  • All chapters include comprehensive background information and are written in a clear form that is accessible also to the non-specialist

Readership

Neuroscientists, psychologists, neurologists

Table of Contents

  • Section I: Genetic and molecular mechanisms of neurodegeneration in PD

    1

    Identifying PD-causing genes and genetic susceptibility factors: current approaches and future prospects

    Thomas Gasser

    2

    The impact of genetic research on our understanding of Parkinson's Disease

    Ted Dawson

    Ian Martin, Valina L. Dawson

    3

    Unraveling the role of defective genes

    Mark Cookson

    4

    What causes the death of dopaminergic neurons in Parkinson’s disease?

    James Surmeier

    Jaime N. Guzman, Javier Sanchez-Padilla and Joshua Goldberg

    5

    Intracellular Signaling Pathways In Dopamine Cell Death And Axonal Degeneration

    Robert Burke

    6

    Control of mitochondrial integrity in Parkinson’s Disease

    Serge Przedborski

    Cristofol Vives-Bauza, Maja Tocilescu, Rosa L. A. deVries, Dana M. Alessi, Vernice Jackson-Lewis

    7

    Role of Post-Translational Modifications in Modulating the Structure, Function and Toxicity of α-synuclein: Implications for Parkinson’s Disease Pathogenesis and Therapies

    Hilal Lashuel

    Abid Oueslati, Margot Fournier

    Section II: Cellular and system-level pathophysiology of the basal ganglia in PD

    8

    The role of dopamine in modulating the structure and function of striatal circuits

    James Surmeier

    Weixing Shen, Michelle Day, Tracy Gertler, Savio Chan, Xianyong Tian and Joshua L. Plotkin

    9

    Assemblies of glutamate receptor subunits with post-synaptic density proteins and their alterations in Parkinson’s disease

    Monica Di Luca

    Paolo Calabresi

    10

    Adenosine-dopamine interactions

    Micaela Morelli

    Anna R Carta, Anil Kachroo, Michael A. Schwarzschild

    11

    Maladaptive plasticity in L-DOPA-induced dyskinesia

    M. Angela Cenci

    Christine Konradi

    12

    Effects of GPi and STN inactivation on physiological, motor, cognitive

    and motivational processes in animal models of Parkinson's disease

    Chistelle Baunez

    Paolo Gubellini

    13

    Computational physiology of the basal ganglia in Parkinson’s disease

    Hagai Bergman

    Michal Rivlin-Etzion, Shlomo Elias, Gali Heimer

    14

    Neurocomputational models of motor and cognitive

    deficits in Parkinson's Disease

    Michael J. Frank

    Thomas V. Wiecki

Product details

  • No. of pages: 332
  • Language: English
  • Copyright: © Elsevier 2010
  • Published: August 20, 2010
  • Imprint: Elsevier
  • eBook ISBN: 9780444536242
  • Hardcover ISBN: 9780444536143
  • About the Serial Volume Editors

    Anders Bjorklund

    As a neuroanatomist and developmental neurobiologist, during the 1970s Björklund’s lab originated reliable methods for transplantation of embryonic tissues into brain that pioneered practical cell transplantation in the central nervous system, providing the basis for technologies that are now used by laboratories world-wide. In parallel, work in the field has progressed from basic anatomical and developmental studies in experimental animals, via applications for assessing cell replacement and repair using primary and stem cells in the damaged brain, and now underpinning the majority of methods in development for cell therapy in patients. His laboratory continues to analyse the fundamental neurobiology and principles of cell transplantation, regeneration and integration in the CNS, as well as originating the first trials of effective clinical cell transplantation (for Parkinson’s disease) in patients

    Affiliations and Expertise

    Lund University, Lund, Sweden

    Angela Cenci-Nilsson

    Angela Cenci-Nilsson
    Angela Cenci Nilsson (author name M. A. Cenci) is Professor of Experimental Medical Research at Lund University (Sweden) where she heads the Basal Ganglia Pathophysiology Group). The group’s research activities address the pathophysiology and pharmacology of Parkinson’s disease (PD) and L-DOPA-induced dyskinesia using a multidisciplinary and translational approach. Current projects span a large variety of topics, including synaptic dysfunctions, dopamine receptor signaling, gliovascular-neuronal interactions, and neurorestorative treatments to enhance function and plasticity in the damaged nigrostriatal pathway. Angela has a combined clinical-basic science background, having graduated in Medicine and specialized in Neurology at the University of Verona (Italy) before obtaining a PhD degree in Neurobiology at Lund University under the supervision of Prof. Anders Björklund. In 2002 Angela received a tenured appointment as Associate Professor at Lund University, which was followed by an appointment as Full Professor in 2008. Angela has pioneered the development of symptomatic models of parkinsonism and L-DOPA-induced dyskinesia in rodents, and exploited these models to discover cellular mechanisms of disease and new therapeutic approaches. For these research achievements, she has received several awards (such as, the Erik K. Fernström Award for Young Promising Investigators, the Medal of Honours for Parkinson´s Research by the Swedish Parkinson’s Disease Foundation, and a recent membership in the Royal Academy for the Natural Sciences, Medicine and Technology in Lund). Angela currently serves on the scientific advisory boards and steering committees of several national and international research organizations, including the Swedish National Microscopy Infrastructure, The Swedish Parkinson’s Research Foundation, the Swedish Brain Foundation, the International Association for Parkinsonism and Related Disorders (IAPDR), and the International Basal Ganglia Society (IBAGS).

    Affiliations and Expertise

    Lund University, Sweden