
Recent Advances in Parkinsons Disease
Part I: Basic Research
Description
Key Features
- Complete overview of hot topics and approaches to current PD research, from molecules, to brain circuits, to clinical and therapeutic applications
- Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research
- All chapters include comprehensive background information and are written in a clear form that is accessible also to the non-specialist
Readership
Table of Contents
Section I: Genetic and molecular mechanisms of neurodegeneration in PD
1
Identifying PD-causing genes and genetic susceptibility factors: current approaches and future prospects
Thomas Gasser
2
The impact of genetic research on our understanding of Parkinson's Disease
Ted Dawson
Ian Martin, Valina L. Dawson
3
Unraveling the role of defective genes
Mark Cookson
4
What causes the death of dopaminergic neurons in Parkinson’s disease?
James Surmeier
Jaime N. Guzman, Javier Sanchez-Padilla and Joshua Goldberg
5
Intracellular Signaling Pathways In Dopamine Cell Death And Axonal Degeneration
Robert Burke
6
Control of mitochondrial integrity in Parkinson’s Disease
Serge Przedborski
Cristofol Vives-Bauza, Maja Tocilescu, Rosa L. A. deVries, Dana M. Alessi, Vernice Jackson-Lewis
7
Role of Post-Translational Modifications in Modulating the Structure, Function and Toxicity of α-synuclein: Implications for Parkinson’s Disease Pathogenesis and Therapies
Hilal Lashuel
Abid Oueslati, Margot Fournier
Section II: Cellular and system-level pathophysiology of the basal ganglia in PD
8
The role of dopamine in modulating the structure and function of striatal circuits
James Surmeier
Weixing Shen, Michelle Day, Tracy Gertler, Savio Chan, Xianyong Tian and Joshua L. Plotkin
9
Assemblies of glutamate receptor subunits with post-synaptic density proteins and their alterations in Parkinson’s disease
Monica Di Luca
Paolo Calabresi
10
Adenosine-dopamine interactions
Micaela Morelli
Anna R Carta, Anil Kachroo, Michael A. Schwarzschild
11
Maladaptive plasticity in L-DOPA-induced dyskinesia
M. Angela Cenci
Christine Konradi
12
Effects of GPi and STN inactivation on physiological, motor, cognitive
and motivational processes in animal models of Parkinson's disease
Chistelle Baunez
Paolo Gubellini
13
Computational physiology of the basal ganglia in Parkinson’s disease
Hagai Bergman
Michal Rivlin-Etzion, Shlomo Elias, Gali Heimer
14
Neurocomputational models of motor and cognitive
deficits in Parkinson's Disease
Michael J. Frank
Thomas V. Wiecki
Product details
- No. of pages: 332
- Language: English
- Copyright: © Elsevier 2010
- Published: August 20, 2010
- Imprint: Elsevier
- eBook ISBN: 9780444536242
- Hardcover ISBN: 9780444536143
About the Serial Volume Editors
Anders Bjorklund
Affiliations and Expertise
Angela Cenci-Nilsson

Affiliations and Expertise
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