Recent Advances in Parkinsons Disease, Volume 183

Section I: Genetic and molecular mechanisms of neurodegeneration in PD

1

Identifying PD-causing genes and genetic susceptibility factors: current approaches and future prospects

Thomas Gasser

2

The impact of genetic research on our understanding of Parkinson's Disease

Ted Dawson

Ian Martin, Valina L. Dawson

3

Unraveling the role of defective genes

Mark Cookson

4

What causes the death of dopaminergic neurons in Parkinson’s disease?

James Surmeier

Jaime N. Guzman, Javier Sanchez-Padilla and Joshua Goldberg

5

Intracellular Signaling Pathways In Dopamine Cell Death And Axonal Degeneration

Robert Burke

6

Control of mitochondrial integrity in Parkinson’s Disease

Serge Przedborski

Cristofol Vives-Bauza, Maja Tocilescu, Rosa L. A. deVries, Dana M. Alessi, Vernice Jackson-Lewis

7

Role of Post-Translational Modifications in Modulating the Structure, Function and Toxicity of α-synuclein: Implications for Parkinson’s Disease Pathogenesis and Therapies

Hilal Lashuel

Abid Oueslati, Margot Fournier

Section II: Cellular and system-level pathophysiology of the basal ganglia in PD

8

The role of dopamine in modulating the structure and function of striatal circuits

James Surmeier

Weixing Shen, Michelle Day, Tracy Gertler, Savio Chan, Xianyong Tian and Joshua L. Plotkin

9

Assemblies of glutamate receptor subunits with post-synaptic density proteins and their alterations in Parkinson’s disease

Monica Di Luca

Paolo Calabresi

10

Adenosine-dopamine interactions

Micaela Morelli

Anna R Carta, Anil Kachroo, Michael A. Schwarzschild

11

Maladaptive plasticity in L-DOPA-induced dyskinesia

M. Angela Cenci

Christine Konradi

12

Effects of GPi and STN inactivation on physiological, motor, cognitive

and motivational processes in animal models of Parkinson's disease

Chistelle Baunez

Paolo Gubellini

13

Computational physiology of the basal ganglia in Parkinson’s disease

Hagai Bergman

Michal Rivlin-Etzion, Shlomo Elias, Gali Heimer

14

Neurocomputational models of motor and cognitive

deficits in Parkinson's Disease

Michael J. Frank

Thomas V. Wiecki

This first volume starts with an overview on current perspectives in genetic research and on the molecular mechanisms of neurodegeneration. This is followed by a selection of hot topics in pathophysiological research, from molecular studies to system-level investigations based on in vivo electrophysiological recordings and neurocomputational methods.

• Complete overview of hot topics and approaches to current PD research, from molecules, to brain circuits, to clinical and therapeutic applications
• Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research
• All chapters include comprehensive background information and are written in a clear form that is accessible also to the non-specialist

Neuroscientists, psychologists, neurologists