Recent Advances in Electron Cryomicroscopy, Part A

Recent Advances in Electron Cryomicroscopy, Part A

1st Edition - November 25, 2010

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  • Editors: B.V Venkataram Prasad, Steve Ludtke
  • eBook ISBN: 9780123813589
  • Hardcover ISBN: 9780123813572

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Description

Structural genomics is the systematic determination of 3-D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome. While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale.

Key Features

  • Examines the three dimensional structure of all proteins of a given organism, by experimental methods such as X-ray crystallography and NMR spectroscopy
  • Looks at structural genomics as a foundation of drug discovery as discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission

Readership

Biochemists, biophysicists, cell biologists, protein chemists, structural geneticists, and structural biologists

Table of Contents

    1. From envelopes to atoms: the remarkable progress of biological electron microscopy
    2. R. Anthony Crowther

    3. Single-particle applications at intermediate resolution
    4. Bettina Böttcher and Katharina Hipp

    5. Visualizing molecular machines in action: single particle analysis with structural variability
    6. Sjors H.W. Scheres

    7. Cellular Tomography

    Andreas Hoenger and Cédric Bouchet-Marquis

Product details

  • No. of pages: 144
  • Language: English
  • Copyright: © Academic Press 2010
  • Published: November 25, 2010
  • Imprint: Academic Press
  • eBook ISBN: 9780123813589
  • Hardcover ISBN: 9780123813572

About the Serial Volume Editors

B.V Venkataram Prasad

Dr. Srividhya Venkataraman has a PhD in Biochemistry and several years of Canadian Postdoctoral experience including tenures as a Canadian Institute of Health Research (CIHR) Fellow at the University Health Network (Toronto General Hospital & Toronto Medical Laboratories, 2005-07), Postdoctoral Fellow at the University of Guelph (2010-2012) and Research Scientist at the University of Toronto, Canada (2007-10, 2013-19). She has extensive experience in the areas of plant virology, plant pathology and plant genetic engineering. Her latest research assignments include production of plant-based vaccines against Hepatitis C Virus (in Prof. Abouhaidar’s laboratory at the University of Toronto) and the Middle East Respiratory Syndrome (MERS) Virus in collaboration with Prof. Kathleen Hefferon at Cornell University, USA. She also serves as Expert Peer Reviewer Selector with Medical Research Council, UK for reviewing grant proposals submitted to the Molecular and Cellular Medicine Board as well as the Infection and Immunity Board. Further, she is a Science Writer and has authored several research publications (including a pioneering research article in the Proceedings of the National Academy of Sciences, USA (2014) which received special mention in PNAS Highlights and over 60 citations thus far), reviews, book chapters and encyclopedia chapters along with established track record of conference presentations. She has a recent first-author publication in the Encyclopedia of Food Security and Sustainability on “Agricultural Innovation and Global Politics of Food Trade”. Also worthy of mention are publications on “Plant Products for Human Health” in the Encyclopedia of Life Sciences and eChapter on Hepatitis: Plant-Made Vaccines to Combat Hepatitis; A Global Perspective (2018), both in the capacity of first author. Her latest book chapter on “Plant Virus Expression Vectors & Nanoparticles” for the book entitled: “Plant Biotechnology”, CRC Press (Taylor and Francis), 2019 is currently under communication.

Affiliations and Expertise

Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada

Steve Ludtke

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