Recent Advances in Cancer Research and Therapy

1st Edition

Editors: Xin-Yuan Liu Sidney Pestka Yu-Fang Shi
Hardcover ISBN: 9780123978332
eBook ISBN: 9780123978363
Imprint: Elsevier
Published Date: 18th May 2012
Page Count: 700
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Description

Cancer continues to be one of the major causes of death throughout the developed world, which has led to increased research on effective treatments. Because of this, in the past decade, rapid progress in the field of cancer treatment has been seen. Recent Advances in Cancer Research and Therapy reviews in specific details some of the most effective and promising treatments developed in research centers worldwide. While referencing advances in traditional therapies and treatments such as chemotherapy, this book also highlights advances in biotherapy including research using Interferon and Super Interferon, HecI based and liposome based therapy, gene therapy, and p53 based cancer therapy. There is also a discussion of current cancer research in China including traditional Chinese medicine. Written by leading scientists in the field, this book provides an essential insight into the current state of cancer therapy and treatment.

Key Features

  • Includes a wide range of research areas including a focus on biotherapy and the development of novel cancer therapeutic strategies.
  • Formatted for a broad audience including all working in researching cancer treatments and therapies.
  • Discusses special traits and results of Chinese cancer research.

Readership

Scientists, researchers, medical professionals, and students working in the various fields related to cancer research and treatment.

Table of Contents

Preface

List of Contributors

1. Cancer Biotherapy: Progress in China

1.1 Introduction

1.2 Immunotherapy

1.3 Gene Therapy

1.4 Antiangiogenesis Therapy

1.5 Targeted Therapy

REFERENCES

2. Cancer Targeting Gene–Viro–Therapy and its Promising Future: A Trend in Both Cancer Gene Therapy and Cancer Virotherapy

2.1 Gene Therapy of Cancer

2.2 Replicating Oncolytic Virus on Cancer Therapy

2.3 Cancer Targeting Gene–Viro–Therapy (CTGVT)

2.4 Modification of CTGVT

2.5 Questions

2.6 Conclusion

Acknowledgments

REFERENCES

3. Relationship Between Antiproliferative Activities and Class I MHC Surface Expression of Mouse Interferon Proteins on B16-F10 Melanoma Cells

3.1 Introduction

3.2 Materials and Methods

3.3 Results

3.4 Discussion

REFERENCES

4. Mitotic Regulator Hec1 as a Potential Target for Cancer Therapy

4.1 Cell Growth and Cancer

4.2 Mitotic Regulators as Cancer Therapy Targets

4.3 Discovery of Hec1, a Novel Protein in Mitotic Regulation

4.4 Development of Hec1 Inhibitors for Cancer Therapeutics

4.5 Conclusion

Acknowledgments

REFERENCES

5. Advances in Liposome-Based Targeted Gene Therapy of Cancer

5.1 Introduction

5.2 Cationic Liposome-Mediated Nonviral Gene Delivery

5.3 Improvement of Therapeutic Efficiency of Liposome-Mediated Gene Therapy

5.4 Improvement of Nonviral Gene Expression System

5.5 Therapeutic Genes for Cancer Gene Therapy

5.6 Conclusion

REFERENCES

6. Rewiring the Intracellular Signaling Network in Cancer

6.1 Introduction

6.2 The JNK Signaling Pathway

6.3 The NF-κB Signaling Pathway

6.4 The Negative Crosstalk Between NF-κB and JNK1 Wires the TNF-α Signaling Circuitry for Cell

Details

No. of pages:
700
Language:
English
Copyright:
© Elsevier 2012
Published:
Imprint:
Elsevier
eBook ISBN:
9780123978363
Hardcover ISBN:
9780123978332

About the Editor

Xin-Yuan Liu

Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China

Affiliations and Expertise

Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China

Sidney Pestka

Affiliations and Expertise

PBL Interferon Source, New Jersey, USA

Yu-Fang Shi

Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China

Affiliations and Expertise

Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China

Reviews

"While referencing advances in traditional therapies and treatments such as chemotherapy, this book also highlights advances in biotherapy including research using Interferon and Super Interferon, HecI based and liposome based therapy, gene therapy, and p53 based cancer therapy."--Doody.com, April 24, 2013