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Recent Advances in Applications of Name Reactions in Multicomponent Reactions is an ideal reference for researchers and postgraduate students studying organic chemistry, as well as synthetic organic chemists working on the development of novel methodologies for the synthesis of various heterocyclic systems, especially drug design and discovery, in both academia and industry. The book reviews recent applications of name reactions in multicomponents for the synthesis of heterocycles and examines recent advances in applications of significant name reactions, such as Ugi and Passirini, Click, Knoevenagel, Michael, Diels-Alder, Aldol, Mannich, Heck, Huisgen, and Suzuki in MCRs.
These reactions can be used in the synthesis of a wide variety of novel heterocycles with different sizes and heteroatoms, as well as in the total synthesis of natural products in order to decrease the number of synthetic steps. Since chiral inductions are necessary for most of these sequential name reactions, their asymmetric catalyzed reactions are also described.
- Includes the synthesis of many heterocycles, which is ideal for synthetic organic chemists engaged in the synthesis of heterocyclic systems
- Covers the recent advances of asymmetric synthesis of a wide range of heterocycles in satisfactory enantioselectivities (ees) or distereoselectivities (des)
- Reviews the synthesis of a wide variety of interesting heterocycles by using a combination of different and versatile name reactions via MCRs
Researchers, graduate and post-graduate students studying synthetic organic chemistry, specifically those involved in the development of new/novel methodologies for the synthesis of various heterocyclic systems. It is especially useful for those groups working in drug design and drug discovery
2. Applications of name reactions in Multicomponent reactions
2.1. Advances in Ugi reaction in MCRs
2.2. Advances in Passerini reaction in MCRS
2.3. Advances in Click reaction in MCRS
2.4. Advances in Knoevenagel reaction in MCRS
2.5. Advances in Michael reaction in MCRS
2.6. Advances in Aldol reaction in MCRS
2.7. Advances in Mannich reaction in MCRS
2.8. Advances in Diels-Alder reaction in MCRS
2.9. Advances in Heck reaction in MCRS
2.10. Advances in Huisgen reaction in MCRS
2.11. Advances in Suzuki reaction in MCRS
3. Multicomponent reaction via combinations of name reactions
3.1. Knoevenagel Reaction/Michael reaction
3.2. Knoevenagel Reaction/Diels-Alder reaction
3.3. Michael Addition/Aldol reaction
3.4. Michael Addition/Mannich reaction
3.5. Ugi reaction/Heck reaction
3.6. Ugi Reaction/Deils-Alder reaction
3.7. Ugi Reaction/ Huisgen reaction
3.8. Ugi Reaction/Aldol reaction
3.9. Heck Reaction/ Suzuki reaction Conclusion References
- No. of pages:
- © Elsevier 2020
- 1st June 2020
- Paperback ISBN:
Majid M Heravi was born in 1952 in Mashhad, Iran. He received his B. Sc. degree from the National University of Iran in 1975 and his M. Sc. and Ph. D. degrees from Salford University, England in 1977 and 1980, respectively. He completed his doctoral thesis under the supervision of the late Jim Clarck in Salford University, England. He started his career as a research fellow in Daroupakhsh (a pharmaceutical company) in 1981 Tehran, Iran and joined as an assistant professor to Ferdowsi University of Mashhad, Iran in 1983, and was promoted to associate professor in 1993 and full professor in 1997. In 1999 he moved to Alzahra University of Tehran, Iran as Professor of Chemistry where he still works. He has previously been a visiting professor at UC Riverside, California, USA and Hamburg University, Hamburg, Germany. His research interests focus on heterocyclic chemistry, catalysis, organic methodology and green synthetic organic chemistry. He has published more than 770 ISI cited papers, including reviews and 12 chapters in Advances in Heterocyclic Chemistry.
Department of Chemistry, School of Sciences, Alzahra University, Vanak, Tehran, Iran
Vahideh Zadsirjan received her B. Sc. in Pure Chemistry from Kharazmi University in 2002, and her M. Sc in 2007 and Ph. D degrees in organic chemistry in 2016 under the supervision of Professor Majid M. Heravi from Alzahra University Tehran, Iran. Her research is focused on heterocyclic chemistry, catalysis, organic methodology and green synthetic organic chemistry.
Department of Chemistry, School of Science, Alzahra University, Vanak, Tehran, Iran