3rd Edition

Scientific Basis of the Disease and Its Management

Editors: Alan Jackson
Hardcover ISBN: 9780123965479
eBook ISBN: 9780123972309
Imprint: Academic Press
Published Date: 16th April 2013
Page Count: 704
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Rabies remains one of the most important global public health problems worldwide. Although many important developments have been made over the past century to combat this ancient disease, Rabies has become a re-emergent infection in the developing world. The 3e updates this classic reference with comprehensive coverage of the molecular virology, pathogenesis, vaccines, public health, immunology, and epidemiology of Rabies. Chapters new to this edition cover biothreat/bioterrorism, successful wildlife control and therapies of human Rabies, and the emergence of new lyssavirus species Rabies provides physicians, public health advisors, epidemiologists, research scientists and veterinarians with single source, authoritative and up-to-date information on the diagnosis, treatment, control and prevention of this fatal infectious virus that continues to kill over 70,000 people a year.

Key Features

  • Rabies remains a significant global public health risk with over 70,000 deaths a year
  • Alan Jackson a well-known researcher in this subject and has gathered a team of experts to detail the science, treatment, and control of Rabies
  • Completely revised, the 3e presents Rabies as a re-emergent infection with greater emphasis on a global perspective of the virus
  • Provides essential information to anyone diagnosing, treating, controlling and preventing the disease
  • 70 full-color figures highlight important information in microscopic studies


Anyone involved in diagnosing, treating, controlling and preventing this disease including: physicians, public health advisors, epidemiologists, research scientists and veterinarians

Table of Contents



List of Contributors

Chapter 1. History of Rabies Research

1 Ancient Greek and Roman times

2 Girolamo Fracastoro

3 John Morgagni

4 Earliest Pathogenesis Studies

5 Louis Pasteur and Rabies Vaccination

6 Earliest Pathogenesis Studies Focused on Pathways of Neural Spread to CNS

7 Adelchi Negri and Negri bodies

8 Paul Remlinger

9 Early Studies Using Electron Microscopy

10 Fluorescent Antibody Staining by Goldwasser and Kissling

11 Pathogenesis Studies in Rodents by Richard T. Johnson and Frederick A. Murphy and Co-workers

12 First Clone of a Rabies Virus Gene


Chapter 2. Rabies Virus

1 Introduction

2 Rabies Virus Architecture

3 Genome and RNP Structures

4 Life Cycle of Rabies Virus Infection


Chapter 3. Epidemiology

1 Introduction

2 Global Epidemiology

3 Routes Of Rabies Virus Transmission

4 Risk and Prevention of Rabies Following an Exposure

5 Epidemiology of Human Rabies in North America and Europe

6 Epidemiology of Human Rabies in Africa and Asia

7 The Burden and Cost of Rabies in Africa and Asia

8 Epizootiology of Rabies in Latin America

9 Case Number Dynamics and Modeling

10 Skunk Rabies Virus Variants

11 Raccoon Rabies in North America

12 Epidemiology of Mongoose-associated Rabies

13 Canine Rabies Virus Variants

14 Conclusions


Chapter 4. Molecular Epidemiology

1 Introduction

2 Methods and Definition of Terms

3 Lyssavirus Taxonomy

4 Future Trends

5 Conclusions




Supplemental References

Chapter 5. Rabies in Terrestrial Animals

1 Introduction

2 What is a Susceptible Host?


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About the Editor

Alan Jackson

Dr. Jackson is Professor of Medicine (Neurology) and of Medical Microbiology and also Head of the Section of Neurology at University of Manitoba in Winnipeg, Manitoba, Canada. He graduated from Queen’s University with BA and MD degrees. He completed an internship in internal medicine at University of Southern California, residencies in internal medicine at Queen’s University and in neurology at the University of Western Ontario, and a fellowship in neurovirology at The Johns Hopkins University with Drs. Richard Johnson and Diane Griffin. Dr. Jackson held a faculty position at Queen’s University from 1987 - 2007. He is on the Editorial Boards of the Journal of NeuroVirology and the Canadian Journal of Neurological Sciences. He is President of Rabies in the Americas, Inc. and is on the Board of Directors of the International Society for Neurovirology. Dr. Jackson is the principal investigator on research grants to study experimental aspects of rabies.

Affiliations and Expertise

Queen's University, Ontario, Canada


"This edition includes many recent developments in the areas of epidemiology, molecular epidemiology, prevention, and treatment of human rabies, and control of wildlife and dog rabies…This book on all aspects of rabies provides worthwhile updates and is a good overall reference for scientists, students, and anyone with an interest in the prevention and control of rabies." Rating: 5 Stars --Doody.com, March 2014

"Laboratory and field specialists in rabies describe developments in understanding, preventing, and treating the disease since the second edition was published in 2007." --Reference & Research Book News, October 2013